[1] FEDERICI JF, SCHULKIN B, HUANG F, et al. THz imaging and sensing for security applications dexplosives, weapons and drugs[J].Semicond Sci Technol, 2005(20):S266
[2] SU K, SHEN YC, ZEITLER JA. Terahertz sensor for non-contact thickness and quality measurement of automobile paints of varying complexity[J].IEEE Transac Terahertz Sci Technol, 2014, 4(4):432
[3] DODGE JS, MOUSAVI P, BUSHFIELD I, et al. Paper parameter estimation using time-domain terahertz spectroscopy[C]//IEEE International Symposium on Optomechatronic Technologies, Seattle, WA, USA, November 5-7, 2014:119, doi:10.1109/ISOT.2014.36
[4] KOENIG S, LOPEZ-DIAZ D, ANTES J, et al. Wireless sub-THz communication system with high data rate[J].Nat Photonics, 2013, 7(12):977
[5] JEPSEN PU, COOKE DG, KOCH M, Terahertz spectroscopy and imaging-modern techniques and applications[J].Laser Photon Rev, 2011(5) 124
[6] ZEITLER JA, GLADDEN LF. In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms[J].Eur J Pharmacokinet Biopharm, 2008,71(1):2
[7] SHEN YC. Terahertz pulsed spectroscopy and imaging for pharmaceutical applications:a review[J].Int J Pharm, 2011, 417(1-2):48
[8] CHIENG N, RADES T, AALTONEN J. An overview of recent studies on the analysis of pharmaceutical polymorphs[J].J Pharm Biomed Anal, 2011, 55(4):618
[9] STRACHAN CJ, RADES T, NEWNHAM DA, et al. Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials[J].Chem Phys Let, 2004, 390(1-3):20
[10] PENKOV NV, YASHIN VA, BELOSLUUDTSEV KN. Hydration shells of DPPC liposomes from the point of view of terahertz time-domain spectroscopy[J].Appl Spectrosc: Soc Appl Spectrosc, 2021, 75(2):189.
[11] MOHARA M, DAVIS MP, KORTER TM, et al. Study on hydration and dehydration of ezetimibe by terahertz spectroscopy with humidity-controlled measurements and theoretical analysis[J].J Phys Chem A, 2022, 126(19):2879
[12] SIBIK J, ZEITLER JA. Direct measurement of molecular mobility and crystal-lisation of amorphous pharmaceuticals using terahertz spectroscopy[J].Adv Drug Deliv Rev, 2016,100(12):147
[13] MENSINK MA, SIBIK J, FRIJLINK HW, et al. Thermal gradient mid and far infrared spectroscopy as tools for characterization of protein carbohydrate lyophilizates[J].Mol Pharm, 2017,14:3550
[14] CICERONE MT, PIKAL MJ, QIAN KK.Stabilization of proteins in solid form[J].Adv Drug Deliv Rev,2015, 93(5):14
[15] SHMOOL TA, HOOPER PJ, SCHIERLE G, et al. Terahertz spectroscopy:an investigation of the structural dynamics offreeze-dried poly lactic-co-glycolic acid microspheres[J].Pharmaceutics, 2019, 11(6):291
[16] SHMOOL TA, WOODHAMS PJ, LEUTZSCH M, et al. Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy[J].Int J Pharm X, 2019(1):100022
[17] WITHAYACHUMNANKUL M, NAFTALY M.Fundamentals of measurement in terahertz time-domain spectroscopy[J].J Infrared Millim Terahertz Waves, 2014, 35:610
[18] MARKL D,WARMAN M, DUMAREY M, et al. Review of real-time release testing of pharmaceutical tablets:state-of-the art, challenges and future perspective[J].Int J Pharm, 2020, 582:119353
[19] TADAY PF, BRADLEY IV, ARNONE DD, et al. Using Terahertz pulse spectroscopy to study the crystalline structure of a drug:a case study of the polymorphs of ranitidine hydrochloride[J].J Pharm Sci, 2003, 92(4) 831
[20] ZEITLER JA, NEWNHAM DA, TADAY PF, et al. Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry[J].J Pharm Sci, 2010, 95(11):2486
[21] TAKEBE G, KAWADA Y, AKIYAMA K, et al. Evaluation of drug crystallinity in aqueous suspension using terahertz time-domain attenuated total reflection spectroscopy[J].J Pharm Sci, 2013, 102(11):4065
[22] DASH J, RAY S, DEVI N, et al. Fine-tuning of terahertz resonances in hydrogen-bonded organic molecular complexes[J].J Mol Struct, 2019, 1184:495
[23] 方虹霞. 太赫兹技术在沙坦类药物多晶、共晶及定量分析中的应用[D].杭州:中国计量学院,2016
FANG HX. Application of terahertz technique in polycrystalline eutectic and quatitative analysis for chatain drugs[D]. Hangzhou: China Jiliang University, 2016
[24] SILVA THD, REXRODE NR, KING MD. Time-domain terahertz spectroscopy and solid-state density functional theory analysis of p-nitrophenol polymorphs[J].J Inf Millim Terahertz Waves, 2020, 41(11):1337
[25] CHARRON DM, AJITO K, KIM JY, et al. Chemicalmapping of pharmaceutica lcocrystals using terahertz spectroscopic imaging[J].Anal Chem, 2013, 85(4):1980
[26] AJITO K, KIM JY, UENO Y, et al. Nondestructive multicomponent terahertz chemical imaging of medicine in tablets[J].J Electrochem Soc, 2014, 161(9):B171
[27] NEILSON R. REXRODE, JORDAN O, et al. Effects of solvent stabilization on pharmaceutical crystallization:investigating conformational polymorphism of probucol using combined solid-state density functional theory[J].J Phys Chem A, 2019, 123(32):6937
[28] WANG P, ZHAO J, ZHANG Y, et al. The Fingerprints of nifedipine/isonicotinamide cocrystal polymorph studied by terahertz time-domain spectroscopy[J].Int J Pharms, 2020,620:121759
[29] WU X, WANG Y, XUE J, et al. Solid phase drug-drug pharmaceutical co-crystal formed between pyrazinamide and diflunisal:structural characterization based on terahertz/Raman spectroscopy combining with DFT calculation[J].Spectrochim Acta Part A:Molec Biomolec Spectrosc, 2020, 234:118265
[30] WANG Y, XUE J, WANG Q, et al. Structural investigation of a 2:1 co-crystal between diflunisal and isonicotinamide based on terahertz and Raman spectroscopy[J].Spectrochim Acta Part A:Molec Biomolec Spectrosc, 2019, 216:98
[31] DU Y, XUE J, HONG Z. Raman and terahertz spectroscopic characterization of solid-state cocrystal formation within specific active pharmaceutical ingredients[J].Curr Pharm Design, 2020, 26:4829
[32] 金顺吉,杜勇. 基于振动光谱技术对阿德福韦药物共晶的结构表征[J].中国计量大学学报, 2020, 31(3):301
JIN SJ, DU Y. Structural characterization of adefovir co-crystal based on vibrational spectroscopy[J].J China Univ Metrol, 2020,31(3):301
[33] 张琪, 方虹霞, 张慧丽,等. γ-氨基丁酸和苯甲酸共晶体及其形成条件的振动光谱分析[J].光谱学与光谱分析, 2017, 37(12):3786
ZHANG Q, FANG HX, ZHANG HL et al. Vibrational spectroscopic characterization of the co-crystal and the forming condition between γ-aminobutyric acid and benzoic acid[J].Spectrosc Spect Anal, 2017, 37(12):3786
[34] TAKEUCHI I, OTSUKI M, KURODA H, et al. Estimation of crystallinity of indomethacin by usage of terahertz time-domain spectroscopy and calibration curve: correlation between crystallinity and solubility[J].J Drug Deliv Sci Technol, 2018, 45(3):70
[35] ERMOLINA I, DARKWAH J, SMITH G.Characterisation of crystalline-amorphous blends of sucrose with terahertz-pulsed spectroscopy:the development of a prediction technique for estimating the degree of crystallinity with partial least squares regression[J].Aaps Pharm Sci Technol, 2014, 15(2):253
[36] SMITH G, HUSSAIN A, BUKHARI N, et al. Quantification of residual crystallinity in ball milled commercially sourced lactose monohydrate by thermo-analytical techniques and terahertz spectroscopy[J].Eur J Pharmacokinet Biopharm, 2015, 92(2):180
[37] SONG M, YANG F, LIU L, et al. Research on differences between 2-(2’-pyridyl)benzimidazole and 2-(4’-pyridyl)benzimidazole based on terahertz time-domain spectroscopy[J].Spectrochim Acta A Mol Biomol Spectrosc, 2017, 191(10):125
[38] SONG M, YANG F, LIU L, et al. Research on the differences between 2-(2-Chlorophenyl)benzimidazole and 2-(4-Chlorophenyl)benzimidazole based on terahertz time domain spectroscopy[J].Spectrochim Acta A Mol Biomol Spectrosc, 2018, 196(2):49
[39] SONG M, YANG F, LIU L, et al. Experimental and theoretical study of fingerprint spectra of 2-(4-fluorophenyl)benzimidazole and 2-(4-chlorophenyl)benzimidazole in terahertz range[J].Spectrochim Acta A Mol Biomol Spectrosc, 2018, 202(5):18
[40] TSE JS.Ab initio molecular dynamics with density functional theory[J].Annu Rev Phys Chem, 2002, 53:249
[41] RUGGIERO MT.Invited review:modern methods for accurately simulating the terahertz spectra of solids[J].J Infrared Millimeter Terahertz Waves, 2020, 41:491
[42] PELLIZZERI S, DELANEY SP, KORTER TM, et al. Using terahertz spectroscopy and solid-state density functional theory to characterize a new poly-morph of 5-(4-pyridyl)tetrazole[J].J Phys Chem A, 2014, 118(2):417
[43] DAVIS MP, MOHARA M, SHIMURA K, et al. Simulation and assignment of the terahertz vibrational spectra of enalapril maleate cocrystal polymorphs[J].J Phys Chem A, 2020, 124(47):9793
[44] HUTEREAU M, BANKS PA, SLATER B, et al. Resolving anharmonic lattice dynamics in molecular crystals with X-ray diffraction and terahertz spectroscopy[J].Phys Rev Lett, 2020, 125(10):103001
[45] DELANEY SP, PAN D, GALELLA M, et al. Understanding the origins of conformational disorder in the crystalline polymorphs of irbesartan[J].Cryst Growth Des, 2012, 12(10):5017
[46] LARSEN AS, RUGGIERO MT, JOHANSSON KE, et al. Tracking dehydration mechanisms in crystalline hydrates with molecular dynamics simulations[J].Cryst Growth Des, 2017,17(10):5017
[47] RUGGIERO MT, ZHANG W, BOND AD, et al. Uncovering the connection between low-frequency dynamics and phase transformation phenomena in molecular solids[J].Phys Rev Lett, 2018, 120(11):196002
[48] LI Q, BOND AD, KORTER TM, et al. New insights into the crystallographic disorder in the polymorphic forms of aspirin from low-frequency vibrational analysis[J].Mol Pharm, 2022, 19(1):227
[49] LI Q, ZACZEK AJ, KORTER TM, et al. Methyl-rotation dynamics in metal-organic frameworks probed with terahertz spectroscopy[J].Chem Commun,2018, 54(45):5776
[50] RUGGIERO MT, SUTTON JJ, FRASER-MILLER SJ, et al. Revisiting the thermodynamic stability of indo-methacin polymorphs with low-frequency vibrational spectroscopy and quantum mechanical simulations[J].Cryst Growth Des, 2018,18:6513
[51] RUGGIERO MT, SIBIK J, ORLANDO R, et al. Measuring the elasticity of poly-l-proline helices with terahertz spectroscopy[J].Angew Chem Int Ed Engl, 2016, 55(24):6877
[52] TARASKIN SN, SIMDYANKIN SI, ELLIOTT SR, et al. Universal features of terahertz absorption in disordered materials[J].Phys Rev Lett, 2006, 97(5):55504
[53] TAN NY, ZEITLER JA. Probing phase transitions in simvastatin with terahertz time-domain spectroscopy[J].Mol Pharm, 2015, 12(3):810
[54] LI R, ZEITLER JA, TOMERINI D, et al. A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acid[J].Phys Chem Chem Phys, 2010,12(20):5329
[55] WILLIAMS HD, TREVASKIS NL, CHARMAN SA, et al. Strategies to address low drug solubility in discovery and development[J].Pharmacol Rev, 2013,65(1):315
[56] LIU X, FENG X, WILLIAMS RO, et al. Characterization of amorphous solid dispersions[J].J Pharm Invest, 2018, 48(17):361
[57] SIBIK J, ELLIOTT SR, ZEITLER JA.Thermal decoupling of molecular-relaxation processes from the vibrational density of states at terahertz frequencies in supercooled hydrogen-bonded liquids[J].J Phys Chem Lett, 2014, 5(11):1968
[58] SIBIK J, LÖBMANN K, RADES T, et al. Predicting crystallization of amorphous drugs with terahertz spectroscopy[J].Mol Pharm, 2015, 12(8) 3062
[59] SIBIK J, SHALAEV EY, ZEITLER JA.Glassy dynamics of sorbitol solutions at terahertz frequencies[J].Phys Chem Chem Phys, 2013, 15(28):11931
[60] KISSI EO, GROHGANZ H, LÖBMANN K, et al. Glass-transition temperature of the b-relaxation as the major predictive parameter for recrystallization of neat amorphous drugs[J].J Phys Chem B, 2018, 122(10):2803
[61] MOORTHY BS, LYER LK, TOPP EM. Characterizing protein structure, dynamics and conformation in lyophilized solids[J].Curr Pharm Design, 2015, 40(21):5845
[62] SIMON E, SEUNG JK, MATTHIAS H, et al. Protein sequence-and pH-dependent hydration probed by terahertz spectroscopy[J].J Amer Chem Soc, 2008, 130(8):2374
[63] ZHANG Z, ZHANG T,FAN F, et al. Terahertz polarization sensing of bovine serum albumin proteolysis on curved flexible metasurface[J].Sens Actuat A:Phys, 2022, 338:113499
[64] TONOUCHI M. Terahertz spectroscopy tracks proteolysis by a joint analysis of absorptance and debye model[J].Biophys J, 2020, 119(12):2469
[65] CAO C, ZHANG Z, ZHAO X, et al. Terahertz spectroscopy and machine learning algorithm for non-destructive evaluation of protein conformation[J].Opt Quant Electron,2020, 52:225
[66] WIRTZ H, SCHAEFER S, HOBERG C, et al. Hydrophobic collapse of ubiquitin generates rapid protein-water motions[J].Biochemistry, 2018, 57(26):3650
[67] WOODS KN. THz time scale structural rearrangements and binding modes in lysozyme-ligand interactions[J].J Biol Phys, 2014, 40(2):121.
[68] 孙怡雯, 钟俊兰, 左剑,等. 血凝素蛋白及抗体相互作用的太赫兹光谱主成分分析[J].物理学报, 2015, 64(16):168701
SUN YW, ZHONG JL,ZUO J, et al. Principal component analysis of terahertz spectrum on hemagglutinin protein and its antibody[J].Acta Phys Sin, 2015, 64(16):168701
[69] MANNA B, NANDI A, TANAKA M, et al. Effect of aggregation on hydration of HSA protein: steady-state Terahertz absorption spectroscopic study[J].J Chem Sci, 2020, 132:8
[70] ZANG Z, YAN S, HAN X, et al. Temperature and pH dependent protein conformational changes investigated by terahertz dielectric spectroscopy[J].Infrared Phys Technol, 2019, 98:260
[71] NAKANISHI A, AKIYAMA K, HAYASHI S, et al. Spectral imaging of pharmaceutical materials with a compact terahertz difference-frequency generation semiconductor source[J].Anal Methods, 2021, 13(46):5549
[72] WEISENSTEIN C, WIGGER A K, RICHTER M, et al. THz Detection of biomolecules in aqueous environments—status and perspectives for analysis under physiological conditions and clinical use[J].J Infrared Millimeter Terahertz Waves, 2021, 42:607
[73] XU W, XIE L, YING Y. Mechanisms and applications of terahertz metamaterial sensing:a review[J].Nanoscale, 2017, 9(37):13864
[74] ADAK S, TRIPATHI LN. Nanoantenna enhanced terahertz interaction of biomolecules[J].Analyst, 2019, 144(21):6172.
[75] SERITA K, MURAKAMI H, KAWAYAMA I, et al. A terahertz-microfluidic chip with a few arrays of asymmetric meta-atoms for the ultra-trace sensing of solutions[J].Photonics, 2019, 6(1):12
[76] ZHANG Z, ZHANG T, FAN F, et al. Terahertz polarization sensing of bovine serum albumin proteolysis on curved flexible metasurface[J].Sens Actuat A:Phys, 2022, 338:113499
