综述专论

中草药寡糖的提取分离、结构鉴定及分析方法研究进展*

  • 郭鸿 ,
  • 么蕊 ,
  • 范晶 ,
  • 郭晓晗 ,
  • 陈佳 ,
  • 段宝忠 ,
  • 王莹 ,
  • 杨建波 ,
  • 蔡伟 ,
  • 荆文光 ,
  • 程显隆 ,
  • 魏锋
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  • 1.中国食品药品检定研究院,北京 100050;
    2.大理大学药学院,大理671000;
    3.湖南医药学院,怀化 418000
第一作者 Tel:18308251993;E-mail:guohong0012@163.com
**王莹 Tel:(010)53852484;E-mail:wangying17@nifdc.org.cn
杨建波 Tel:(010)53852101;E-mail:yangjianbo@nifdc.org.cn

收稿日期: 2024-08-20

  网络出版日期: 2025-08-25

基金资助

*国家自然基金青年资助项目(82204617); 中国食品药品检定研究院学科带头人培养基金课题(2023x8)

Research progress on extraction, isolation, structural identification and analytical methods of oligosaccharides from Chinese herbal medicine*

  • GUO Hong ,
  • YAO Rui ,
  • FAN Jing ,
  • GUO Xiao-han ,
  • CHEN Jia ,
  • DUAN Bao-zhong ,
  • WANG Ying ,
  • YANG Jian-bo ,
  • CAI Wei ,
  • JING Wen-guang ,
  • CHENG Xian-long ,
  • WEI Feng
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  • 1. National Institutes for Food and Drug Control, Beijing 100050, China;
    2. College of Pharmaceutical Science, Dali University, Dali 671000, China;
    3. Hunan University of Medicine, Huaihua 418000, China

Received date: 2024-08-20

  Online published: 2025-08-25

摘要

寡糖是中草药中来源丰富的一类活性成分,具有抗抑郁,抗阿尔茨海默病等临床功效以及降血糖、润肠通便、增强免疫等多种药理活性。寡糖的活性与结构密切相关,但由于糖苷键构型、单糖组成、连接方式的多样性,常规分析手段难以得到准确结构,建立快速、可靠的分析方法仍是糖类物质研究的重点和难点。目前,对于寡糖的研究报道日益增加,但缺乏对于中草药寡糖结构和分析方法的全面总结,本文通过查阅国内外文献,对近10年来中草药中寡糖的提取分离、结构鉴定、分析方法等方面进行系统的综述,有助于建立基于寡糖类成分的中药评价方法,为寡糖在中药质量控制中的应用提供参考。

本文引用格式

郭鸿 , 么蕊 , 范晶 , 郭晓晗 , 陈佳 , 段宝忠 , 王莹 , 杨建波 , 蔡伟 , 荆文光 , 程显隆 , 魏锋 . 中草药寡糖的提取分离、结构鉴定及分析方法研究进展*[J]. 药物分析杂志, 2025 , 45(3) : 361 -391 . DOI: 10.16155/j.0254-1793.2024-1061

Abstract

Oligosaccharides are a class of bioactive components abundantly found in Chinese herbal medicine. They have clinical effects such as antidepressant and anti-Alzheimer’s disease activities, as well as pharmacological activities such as hypoglycemic, laxative, and immune-enhancing effects. The bioactivity of oligosaccharides is closely related to their structure. However, due to the diversity of glycosidic bond configurations, monosaccharide compositions and linkage patterns, it is difficult to accurately determine their structures by conventional analytical methods. Establishing rapid and reliable analytical methods remains a key challenge in carbohydrate research. Although studies on oligosaccharides are increasing, there is a lack of comprehensive reviews on the structure and analytical methods of oligosaccharides in Chinese herbal medicine. This paper systematically reviewed the research progress over the past decade on extraction, separation, structure identification and analytical methods of oligosaccharides in Chinese herbal medicine by consulting domestic and foreign literatures. This review aims to contribute to the development of evaluation method of traditional Chinese medicine based on oligosaccharide components, and provide reference for their application in the quality control of traditional Chinese medicine.

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