目的: 研究矫味物料和掩味层增重对盐酸氨溴索苦味的改善效果,建立客观、科学的口感评价方法。方法: 采用电子舌技术,对矫味物料和掩味层增重的掩味效果进行评价,并对比盐酸氨溴索直服颗粒与15种已上市的盐酸氨溴索制剂的适口性;对电子舌数据进行主成分分析和载荷分析。结果: 矫味物料能够掩盖盐酸氨溴索本身的苦味;随着掩味层增重变大盐酸氨溴索直服颗粒样品溶液的苦味值降低;在苦味与甜味方面,盐酸氨溴索直服颗粒相较于15种已上市的盐酸氨溴索制剂具有明显的优势。结论: 利用电子舌技术,能够精准评估矫味效果及不同样品之间的味觉差异,建立了盐酸氨溴索直服颗粒苦味掩盖效果的评价方法,为儿童口服制剂的掩味研究提供新的思路和方法。
Objective: To investigate the improvement in bitter taste of ambroxol hydrochloride by the corrective materials and weight gain of the taste-masking layer, and to establish an objective and scientific taste evaluation method. Methods: The taste-masking effects of corrective materials and taste-masking layer weighting were evaluated using electronic tongue technology, and the palatability between ambroxol hydrochloride direct oral granules and 15 marketed preparations of ambroxol hydrochloride were compared. The electronic tongue datas were subjected to principal component analysis and loadings analysis. Results: The corrective materials were able to mask the bitter taste of ambroxol hydrochloride. The bitter value of the sample solution of ambroxol hydrochloride direct oral granules decreased as the masking layer gained weight. In terms of bitterness and sweetness, ambroxol hydrochloride oral direct granules had a clear advantage over 15 marketed formulations. Conclusion: Using the electronic tongue technology, the taste correction effect and the taste difference between different samples can be accurately assessed, and an evaluation method for the bitter taste masking effect of ambroxol hydrochloride direct oral granules has been established, which provides new ideas and methods for the taste masking study of oral preparations for children.
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