综述专论

真菌类中药质量标准及检测技术研究进展*

  • 李文庆 ,
  • 温宝庆 ,
  • 谭国英 ,
  • 周妙霞 ,
  • 林坤霞 ,
  • 钱正明
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  • 珠海横琴东阳光冬虫夏草有限公司, 珠海 519031
第一作者 Tel:(0769)85315888;E-mail:liwenqing61@163.com
**Tel:(0769)85315888;E-mail:qianzhengming1982@126.com

收稿日期: 2024-09-05

  网络出版日期: 2025-11-13

基金资助

*工信部年度中药材提升和保障领域项目(冬虫夏草规模化生产基地建设)

Advances in quality standards and control of fungal Chinese medicine*

  • LI Wen-qing ,
  • WEN Bao-qing ,
  • TAN Guo-ying ,
  • ZHOU Miao-xia ,
  • LIN Kun-xia ,
  • QIAN Zheng-ming
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  • Zhuhai Hengqin HEC Cordyceps Co., Ltd., Zhuhai 519031, China

Received date: 2024-09-05

  Online published: 2025-11-13

摘要

真菌类中药作为中医药产业的重要组成部分,在临床应用中日益增多。本文统计了我国颁布的真菌类中药质量标准共计442项,其中《中华人民共和国药典》标准19项,地方标准398项,其他法定标准包括局颁标准、部颁标准25项;共涉及真菌中药品种67种,涉及真菌物种66种。本文在分析现有质量标准的基础上,从真菌类中药质量控制的角度,系统论述了真菌类中药的性状、显微特征、DNA鉴别、理化鉴别、含量测定(多糖、核苷、甾醇、萜类、蛋白/肽、酯类、糖醇等)、有害物质等质量特征及相关技术;并对真菌类中药质量标准未来的发展提出了建议,为真菌类中药的质量评价提升及质量保障提供参考。

本文引用格式

李文庆 , 温宝庆 , 谭国英 , 周妙霞 , 林坤霞 , 钱正明 . 真菌类中药质量标准及检测技术研究进展*[J]. 药物分析杂志, 2025 , 45(7) : 1137 -1156 . DOI: 10.16155/j.0254-1793.2024-1114

Abstract

As one crucial resource of Chinese medicines, fungal Chinese medicine have been extensively used in clinic. This article has compiled a total of 442 standards for fungal Chinese medicine that have been issued in China, including 19 Chinese Pharmacopoeia standards, 398 local standards and 25 bureau or ministry standards. The fungal Chinese medicine are composed by 67 traditional Chinese medicine varieties from 66 fungal species. Based on the review of those quality standards, the characteristics and quality evaluation of fungal Chinese medicine such as medicinal property, microscope appearance, DNA based identification and physicochemical identification, assay (polysaccharides, nucleosides, sterols, terpenes, proteins/peptides, esters, sugar alcohols, etc.), microbial and harmful substances, as well as related analytical techniques are summarized. This review will certainly provide the comprehensive understanding of current research and development of fungal Chinese medicinal materials.

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