Research progress on the mechanism of action and bioactivity methods of human thyroid-stimulating hormone*

GAO Jing, LIANG Cheng-gang, LI Jing

Chinese Journal of Pharmaceutical Analysis ›› 2024, Vol. 44 ›› Issue (7) : 1105-1112.

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Chinese Journal of Pharmaceutical Analysis ›› 2024, Vol. 44 ›› Issue (7) : 1105-1112. DOI: 10.16155/j.0254-1793.2024-0226
Review & Monography

Research progress on the mechanism of action and bioactivity methods of human thyroid-stimulating hormone*

  • GAO Jing1,2, LIANG Cheng-gang2**, LI Jing2**
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Abstract

Thyroid-stimulating hormone (TSH) is a glycoprotein hormone produced by the anterior pituitary. It can regulate the synthesis and secretion of thyroid hormone in thyroid follicular cells, which has important physiological significance. As a drug, it has important application value. Biological activity detection is an effective and necessary to evaluate its quality. This article discusses the signal transduction mechanism of thyroid stimulating hormone, the clinical diagnosis and treatment of thyroid stimulating hormone, and the determination method of biological activity.

Key words

thyroid-stimulating hormone / signal transduction mechanism / diagnosis and treatment / osteoporosis / thyroid cancer / polycystic ovary syndrome / biological activity assay

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GAO Jing, LIANG Cheng-gang, LI Jing. Research progress on the mechanism of action and bioactivity methods of human thyroid-stimulating hormone*[J]. Chinese Journal of Pharmaceutical Analysis, 2024, 44(7): 1105-1112 https://doi.org/10.16155/j.0254-1793.2024-0226

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