Determination of clopidogrel and its metabolites in human liver microsomes and its application to enzyme kinetics of clopidogrel

LIU Shuai-bing^1,2, WANG Zi-teng^1,2, XU Qing-qing^1,2, MIAO Li-yan^1,2

Chinese Journal of Pharmaceutical Analysis ›› 2015, Vol. 35 ›› Issue (10) : 1741-1750.

Determination of clopidogrel and its metabolites in human liver microsomes and its application to enzyme kinetics of clopidogrel

LIU Shuai-bing^1,2, WANG Zi-teng^1,2, XU Qing-qing^1,2, MIAO Li-yan^1,2

Author information +

History +

Key words

clopidogrel; active metabolite; inactive metabolite; HPLC; UPLC tandem mass spectrometry; human liver microsomes; drug concentrations; protein precipitation; in vitro metabolism study

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LIU Shuai-bing^1,2, WANG Zi-teng^1,2, XU Qing-qing^1,2, MIAO Li-yan^1,2. Determination of clopidogrel and its metabolites in human liver microsomes and its application to enzyme kinetics of clopidogrel[J]. Chinese Journal of Pharmaceutical Analysis, 2015, 35(10): 1741-1750