Objective: To study the elution and adsorption effect of nylon and polyether sulfone needle filters in chromatographic tests from 6 domestic manufacturers. Methods: Organic reagents (methanol and acetonitrile) were selected for elution test and filtered by nylon needle filters. The elution peaks were detected by liquid chromatography. Standard solutions of lincomycin, clarithromycin and roxithromycin with different concentrations for adsorption test were filtered by needle filters and determined by LC-MS, and the recovery rate was calculated. Results: There were residue peaks which could be eluted by acetonitrile and methanol in nylon needle filters from 6 manufacturers. The adsorption effect of polyether sulfone needle filters from different manufacturers was different, and the adsorption degree of polyether sulfone needle filters from the same manufacturer was also different. As the concentration of filtered solution decreases, the volume of initial filtrate to be discarded tends to increase. As the volume of discarded filtrate increases, the adsorbed material was likely to be released. Conclusion: It is suggested that the elution and adsorption effects of needle filters should be fully evaluated when using needle filter for chromatographic pretreatment.
SU Tan
. Study on elution and adsorption effect of disposable needle filters[J]. Chinese Journal of Pharmaceutical Analysis, 2023
, 43(11)
: 1891
-1896
.
DOI: 10.16155/j.0254-1793.2023.11.11
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