Objective: To focus on the composition of two kinds of white beeswax(Chinese beeswax and Western beeswax) and their correlation with rheological properties. Methods: The difference of alkane composition between Chinese beeswax and Western beeswax was determined by gas chromatography-mass spectrometry with HP-5ms column, gradient heating, and scaning in the range of m/z 50-550. The alkane composition of white beeswax from different sources was determined by gas chromatography, DB-5 column, gradient heating, hydrogen flame ionization detector, and was calculated by area normalization method. The rheological modulus, viscoelasticity and yield value of Chinese beeswax and Western beeswax were measured by rheometer in shear rate scanning mode (shear rate range: 0.1-100 s-1) and temperature scanning mode (temperature range: 70-60 ℃, cooling rate: 4 ℃·min-1). Results: The proportion of long-chain alkanes in Western beeswax detected by gas chromatography was significantly higher than that in Chinese beeswax (more than 50% of the alkane carbon chains in Western beeswax was greater than 27, while only 17.4% of the alkane carbon chains in Chinese beeswax was greater than 27). Due to the larger number of alkane carbon chains in Western beeswax, Western beeswax showed the property of storage modulus. The temperature transition point of Western beeswax from viscoelastic solid to viscoelastic fluid was higher than that of Chinese beeswax. The yield value of Western beeswax was higher than that of Chinese beeswax, and the viscosity of Western beeswax was higher than that of Chinese beeswax at the same shear rate. Conclusion: The alkane composition of white beeswax from different sources is different, resulting in a series of rheological parameters of white beeswax from different sources. These differences should be paid attention to in the formulation design of ointment.
YANG Rui, XU Kai, LI Pan-pan, WANG Xiao-feng, ZHANG Jing, XIAO Xin-yue
. Study on structure-rheological activity relationship of pharmaceutical excipients white beeswax[J]. Chinese Journal of Pharmaceutical Analysis, 2021
, 41(10)
: 1775
-1781
.
DOI: 10.16155/j.0254-1793.2021.10.15
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