Safety Monitoring

Influence of water activity on the stability of cefoperazone sodium and sulbactam sodium for injection

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  • Suzhou Institute for Drug Control, Suzhou 215104, China

Received date: 2022-11-21

  Online published: 2024-06-24

Abstract

Objective: To investigate the influence of water activity on the stability of cefoperazone sodium and sulbactam sodium for injection. Methods: Water content, water activity, cefoperazone sodium assay, sulbactam sodium assay and related substances were studied under the condition of (25±1) ℃ and (75±1)% humidity. Results: The stability of cefoperazone sodium and sulbactam sodium for injection was correlated with water activity and water content. The sample with lower water activity was more stable. Conclusion: Water activity and water content are the key quality control property of cefoperazone sodium and sulbactam sodium for injection.

Cite this article

CHEN Rong, WANG Ying-yu, GUO Bin, ZHOU Zhen-yu, ZHANG Hua-feng . Influence of water activity on the stability of cefoperazone sodium and sulbactam sodium for injection[J]. Chinese Journal of Pharmaceutical Analysis, 2023 , 43(9) : 1514 -1522 . DOI: 10.16155/j.0254-1793.2023.09.09

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