Quality Control

Study on multiple index comprehensive evaluation of the extraction process of Jichuan decoction*

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  • 1. Chengdu Integrated TCM&Western Medicine Hospital, Chengdu 610095, China;
    2. Institute of Traditional Chinese Medicine, Sichuan Academy of Chinese Medical Sciences, Chengdu 610014, China

Received date: 2023-03-16

  Online published: 2024-06-24

Abstract

Objective: To optimize the extraction process of classical famous prescription of Jichuan Decoction. Methods: HPLC was employed to determine multiple components in Jichuan Decoction. Using contents of echinacea glycoside, isoferulic acid, mullein glycoside, naringin and neohesperidin and yield of dry extract of the above components as comprehensive evaluation indexes, information entropy weighting method was used to determine the objective weight of each index, and orthogonal test was used to investigate effects of solvent dosage, extraction time and times on extraction process. Results: The specificity, linearity, precision, stability, repeatability and sample recovery rate met the requirements, the optimal extraction conditions of Jichuan Decoction was extracted for 3 times with 6 times of water quantity, each for 40 min. The mean of comprehensive evaluation index for 3 batches was 91.94 and the RSD was 1.1%. Conclusion: The optimized extraction process is scientific, stable and feasible, which provides a reference basis for the production of Jichuan Decoction.

Cite this article

SHI Chong-jing, FENG Jian-an, HUANG Yan, WANG Yu . Study on multiple index comprehensive evaluation of the extraction process of Jichuan decoction*[J]. Chinese Journal of Pharmaceutical Analysis, 2023 , 43(9) : 1597 -1602 . DOI: 10.16155/j.0254-1793.2023.09.17

References

[1] 牛林强,吴丽林,易腾达,等. 经典名方济川煎古今文献分析 [J]. 中医药学报,2022,50(5):48
NIU LQ, WU LL, YI TD, et al. Research on ancient and modern literature of classical prescription of Jichuan decoction [J]. Acta Chin Med Pharm, 2022, 50(5):48
[2] 岳奇. 阳虚便秘动物模型的建立及济川煎治疗作用研究 [D]. 太原:山西省中医药研究院,2017
YUE Q. The Establishment of Animal Model with Yang-Deficiency and Constipation and Study on the Therapeutic Effect of Ferry Brew [D]. Taiyuan:Shanxi Provincial Institute of TCM, 2017
[3] 赵阳武. 不同接种年限肉苁蓉指标成分和功效研究 [D]. 兰州:甘肃农业大学,2018
ZHAO YW. The Study of Contents and Efficiencies of Different Inoculation Years Cistanches deserticola [D]. Lanzhou: Gansu Agricultural University, 2018
[4] 冯慧敏,李玥,罗旭东,等. 当归化学成分和药理作用研究进展及质量标志物的预测分析 [J]. 中华中医药学刊,2022,40(4):159
FENG HM, LI Y, LUO XD, et al. Research progress on chemical constituents and pharmacological effects of Danggui (Radix Angelicae Sinensis) and prediction analysis on its quality markers [J]. Chin Arch Tradit Chin Med, 2022, 40(4):159
[5] 尚风琴. 怀牛膝与川牛膝功能活性成分的比较研究 [D]. 北京:中国科学院大学,2016
SHANG FQ. Comparative Study on Achvranthese bidentata Bl and Cyathula officinalis Kuan [D]. Beijing:University of Chinese Academy of Sciences,2016
[6] 邢增智,陈旺,曾宇. 泽泻的化学成分与药理作用研究进展 [J]. 中医药导报,2017,23(15):75
XING ZZ, CHEN W, ZENG Y. Research progress on chemical constituents and pharmacological effects of Zexie (Alisma orientalis) [J]. Guid J Tradit Chin Med Pharm, 2017, 23(15):75
[7] 李陈雪,杨玉赫,冷德生,等. 枳壳化学成分及药理作用研究进展 [J]. 辽宁中医药大学学报,2019,21(2):158
LI CX,YANG YH, LENG DS, et al. Research progress on chemical constituents and quality evaluation of Fructus Aurantii [J]. J Liaoning Univ Tradit Chin Med, 2019, 21(2):158
[8] 陈李乙,李佳欣,张美晴,等. 升麻药材化学成分及药理作用研究进展 [J]. 中草药,2023,54(5):1685
CHEN LY, LI JX, ZHANG MQ, et al. Research progress on chemical composition and pharmacological effects of Cimicifugae Rhizoma [J]. Chin Tradit Herb Drug, 2023, 54(5):1685
[9] 施崇精,李希,冯建安,等. 古代经典名方济川煎物质基准HPLC特征指纹图谱研究 [J]. 中草药,2020,51(15):3930
SHI CJ, LI X, FENG JA, et al. Study on HPLC characteristic fingerprint of substance benchmark of classical famous prescription of Jichuan decoction [J]. Chin Tradit Herb Drug, 2020, 51(15):3930
[10] 谭娥玉,关琴笑,王贤儿,等. 天芷金黄凝胶贴膏提取工艺的优化 [J]. 中成药,2019,41 (8):1946
TAN EY, GUAN QX, WANG XE, et al. Optimization of extraction process of Tianzhi Jinhuang gel paste [J]. Chin Tradit Pat Med, 2019, 41(8):1946
[11] 徐志伟,马新换,李季文,等. 基于多指标评价优选四妙勇安汤发酵物的片剂处方 [J]. 药物分析杂志,2021,41(11):2031
XU ZW, MA XH, LI JW, et al. Optimization of fermented Simiao Yongan decoction tablets based on multi-index evaluation method [J]. Chin J Pharm Anal, 2021, 41(11):2031
[12] 陈丽津,汤浩,石磊,等. 基于信息熵理论的正交设计优化消乳增胶囊的提取工艺 [J]. 中草药,2019,50(14):3345
CHEN LJ, TANG H, SHI L, et al. Optimization of extraction process of Xiaoruzeng Capsules based on orthogonal design in information entropy theory [J]. Chin Tradit Herb Drugs, 2019, 50(14):3345
[13] 赵琳琳,赵云平,魏静娜,等. 正交试验优选知母酒制工艺 [J]. 药物分析杂志,2018,38(11):2038
ZHAO LL, ZHAO YP, WEI JN, et al. Optimization of processing technology of Rhizoma Anemarrhenae with wine by orthogonal test [J]. Chin J Pharm Anal, 2018, 38(11):2038
[14] 林大专,张义英,王俊儒. 丹参中有效成分联合提取工艺的优化 [J]. 中成药,2019,41(6):1392
LIN DZ, ZHANG YY, WANG JR. Optimization of combined extraction process of active ingredient from Salvia miltiorrhiza [J]. Chin Tradit Pat Med, 2019, 41(6):1392
[15] 彭璐,张志杰,龚千锋,等. 多指标加权法优选醋五倍子炮制工艺 [J]. 药物分析杂志,2017,37(9):1733
PENG L, ZHANG ZJ, GONG QF, et al. Processing technology of vinegared Galla Chinensis evaluated by multi index weighted method [J]. Chin J Pharm Anal, 2017, 37(9):1733
[16] 王继龙,魏舒畅,刘永琦,等. 基于G1-熵权法和正交设计优选黄芪百合颗粒的提取纯化工艺 [J]. 中草药,2018,49(3):596
WANG JL, WEI SC, LIU YQ, et al. Optimization of extraction and purification technology for Huangqi Baihe Granules based on G1-entropy method and orthogonal design [J]. Chin Tradit Herb Drugs, 2018, 49(3):596
[17] 孟灵旭,张静,张洪涛,等. 基于信息熵理论和反向传播人工神经网络优选人参真空冷冻干燥工艺 [J]. 时珍国医国药,2023,34(1):91
MENG LX, ZHANG J, ZHANG HT, et al. Optimization of vacuum freeze-drying process of ginseng based on information entropy theory and artificial neural network [J]. Lishizhen Med Mater Med Res, 2023, 34(1):91
[18] 赵艳云,张建云,郑开颜,等. 基于信息熵赋权结合Box-Behnken响应面法优化北苍术提取工艺 [J]. 中华中医药学刊,2022,40(6):86
ZHAO YY, ZHANG JY, ZHENG KY, et al. Optimization of extraction process of Beicangzhu (Atractylodes chinensis) by combination of response surface methodology with information entropy weight method [J]. Chin Arch Tradit Chin Med, 2022, 40(6):86
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