Objective: To establish a rapid and accurate method for the identification and determination of 16 drugs illegally added in far infrared stickers. Methods: Samples were refluxed in methanol. High performance liquid chromatography (HPLC) and liquid chromatography tandem high resolution mass spectrometry (LC-HRMS/MS) were used for qualitative analysis of illegally added drugs, and HPLC was used for content determination. Results: The 16 compounds showed good linear relationship within their ranges, and the correlation coefficients(r) were above 0.999. Under three different concentration levels, the recoveris ranged from 81.1% to 112.7% with the RSDs of 0.010% to 2.8% at the three concentration levels. The LODs were in range of 0.05-1.5 μg·mL-1 and the LOQs were in range of 0.2-5 μg·mL-1. Diclofenac sodium was detected in 9 of the 35 samples in range of 0.56-37.11 mg per sticker. Conclusion: The method is simple, specific, highly sensitive and accurate, and can be used for the detection of the 16 drugs illegally added in far infrared stickers and similar products.
DU Fu-ying, ZHANG Hua-mei, WANG Chen-xiao, WU Chang-yan, ZHANG Li-ying, WAN Min, SHEN Yong
. Identification and determination of 16 drugs illegally added in far infrared stickers*[J]. Chinese Journal of Pharmaceutical Analysis, 2022
, 42(2)
: 329
-334
.
DOI: 10.16155/j.0254-1793.2022.02.18
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