Review & Monography

Research progress on the main application of Raman spectroscopy in the analysis of traditional Chinese medicines*

Expand
  • Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China

Revised date: 2023-04-04

  Online published: 2024-06-25

Abstract

With the continuous deepening of research on traditional Chinese medicine, traditional analysis methods can no longer meet the needs of modern Chinese medicine development. As an emerging analytical method, Raman spectroscopy has been included as a crystal form detection method by EP, BP, ChP and so on. However, the application of Raman spectroscopy in the field of traditional Chinese medicine is still not extensive and in-depth. This article introduces the application of Raman spectroscopy in traditional Chinese medicine identification, content determination, and component peak attribution in the past two decades. At the same time, it points out the problems in the analysis of traditional Chinese medicine. It is hoped to provide strong support for the further application of Raman spectroscopy in the analysis of traditional Chinese medicine.

Cite this article

ZHANG Wei-ye, ZHUO Xue-qun, RAN Mao-hua, ZHAO Yao-wei, WANG Rui . Research progress on the main application of Raman spectroscopy in the analysis of traditional Chinese medicines*[J]. Chinese Journal of Pharmaceutical Analysis, 2023 , 43(4) : 543 -549 . DOI: 10.16155/j.0254-1793.2023.04.01

References

[1] BAI Y. A method of acquiring Raman spectrum for blood samples with low cost[J]. Chin J Biomed Eng, 2021, 30(2):69
[2] PAN WW, ZHOU JQ, ZHANG L, et al. Raman dissipative soliton fiber laser mode locked by a nonlinear optical loop mirror[J]. Opt Express, 2019, 27(13):17905
[3] SMITH GD, ESSON JM, CHEN VJ, et al. Forensic dye analysis in cultural heritage: unraveling the authenticity of the earliest Persian knotted-pile silk carpet[J]. Forensic Sci Int Synerg, 2021, 3: 100130
[4] 郭淑霞. 表面增强拉曼光谱信息处理技术的研究与应用[D]. 厦门: 厦门大学, 2014
GUO SX. Study and Application of Data Processing Technology for SERS Spectrum[D]. Xiamen: Xiamen University, 2014
[5] NORDIN F. Introduction à la spectroscopie Raman classique et à la diffusion Raman exaltée de surface[J]. Photoniques, 2019, 96: 39
[6] 宋浩然, 尚培华. 在线拉曼光谱分析技术在石化领域中的应用[J]. 石化技术, 2020, 27(8):59
SONG HR, SHANG PH. Application of online Raman spectroscopy analysis technology in petrochemical field[J]. Petrochem Ind Technol, 2020, 27(8):59
[7] RAVINDER G, PITCHAMUTHU M, DURGACHALAM M, et al. Noble metal ion embedded nanocomposite glass materials for optical functionality of UV-visible surface plasmon resonance(SPR) surface-enhanced Raman scattering(SERS) X-ray and electron microscopic studies: an overview[J]. Plasmonics, 2021, 16: 1461
[8] JAWORSKA A, MALEK K, KUDELSHI A. Intracellular pH-advantages and pitfalls of surface-enhanced Raman scattering and fluorescence microscopy―a review[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2020, 251: 119410
[9] ZHAO FT, WANG WP, ZHONG HD, et al. Robust quantitative SERS analysis with relative Raman scattering intensities[J]. Talanta, 2021, 221: 121465
[10] 周健, 杨世颖, 靳桂民, 等. 拉曼光谱技术在药物晶型研究中应用进展[J]. 医药导报, 2019, 38(2):197
ZHOU J, YANG SY, JIN GM, et al. Application progress of Raman spectroscopy in the study of drug polymorphism[J]. Her Med, 2019, 38(2):197
[11] WANG ZF, WANG L, XIAO FA, et al. A traditional Chinese medicine traceability system based on lightweight blockchain[J]. J Med Internet Res, 2021, 23(6):25946
[12] 刘影, 汪晓娟, 刘龙. 拉曼光谱在三七中药识别中应用[J]. 海峡药学, 2020, 32(8):60
LIU Y, WANG XJ, LIU L. Application of Raman spectra in the identification of Panax notoginseng[J]. Strait Pharm J, 2020, 32(8):60
[13] 黄秀丽, 詹云丽, 李菁, 等. 便携式激光拉曼光谱仪快速鉴别灵芝孢子油掺伪[J]. 食品工业科技, 2016, 37(20):59
HUANG XL, ZHAN YL, LI J, et al. Rapid detection of spore oil from Ganoderma lucidum by portable laser Raman spectroscopy[J]. Sci Technol Food Ind, 2016, 37(20):59
[14] 冯源, 高丽君, 韩笑, 等. 拉曼光谱联合ICP-AES法鉴定鹿茸真伪[J]. 中成药,2020, 42(2):523
FENG Y, GAO LJ, HAN X, et al. Raman spectroscopy combined with ICP-AES to identify the authenticity of velvet antler[J]. Chin Tradit Pat Med, 2020, 42(2):523
[15] 张凡, 陈龙, 黄必胜, 等. 应用X射线衍射及拉曼光谱鉴别白石英[J]. 中国医院药学杂志, 2017, 37(24):2443
ZHANG F, CHEN L, HUANG BS, et al. Identification of quartz by X-ray and Raman spectroscopy[J]. Chin J Hosp Pharm, 2017, 37(24):2443
[16] 胡晓宇, 杨馨玥, 姚金剑, 等. 中药现场鉴定技术研究进展[J]. 药学研究, 2019, 38(12):724
HU XY, YANG QY, YAO JJ, et al. Research progress of technologies used for identification of traditional Chinese medicine on scene[J]. J Pharm Res, 2019, 38(12):724
[17] 陈龙, 袁明洋, 明晶, 等. 基于改进siPLS法建立5种含CaCO3中药的拉曼光谱定量模型[J]. 中国中药杂志, 2015, 40(18):3608
CHEN L, YUAN MY, MING J, et al. Establishment of Raman spectroscopic quantitative models of 5 Chinese medicines containing CaCO3 based on improved siPLS method[J]. China J Chin Mater Med, 2015, 40(18):3608
[18] QI X, ZENG CC, LIU HP, et al. Rapid quantitative analysis of puerarin using Raman spectroscopy[J]. Spectroscopy, 2013, 28(4):34
[19] 李佳佳, 刘靖丽, 靳如意, 等. 激光拉曼光谱分析中药复方制剂中青蒿素含量的研究[J]. 光谱学与光谱分析, 2019, 39(8):2403
LI JJ, LIU JL, JIN RY, et al. Quantitative measurement of artemisinin content in Chinese traditional compound medicine by Raman spectroscopy[J]. Spectrosc Spect Anal, 2019, 39(8):2403
[20] ZHOU YH, ZUO ZT, XU FR, et al. Origin identification of Panax notoginseng by multi-sensor information fusion strategy of infrared spectra combined with random forest[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2020, 226: 117619
[21] MENG XD, YANG F, DONG HF, et al. Recent advances in optical imaging of biomarkers in vivo[J]. Nano Today, 2021, 38: 101156
[22] HAO BQ, WU JW, DING YR, et al. Rapid determination of propylthiouracil and methimazole by surface-enhanced Raman scattering based on sodium alginate-protected silver nanoparticles[J]. Anal Bioanal Chem, 2020, 412(28):7827
[23] LI MT, ZHANG X. Nanostructure-based surface-enhanced Raman spectroscopy techniques for pesticide and veterinary drug residues screening[J]. Bull Environ Contam Toxicol, 2020, 107(2):194
[24] YAO GH, MA YH. MUHAMMAD M, et al. Understanding the infrared and Raman spectra of ganoderic acid A: an experimental and DFT study[J]. Spectrochim A Mol Biomol Spectrosc, 2019, 210: 372
[25] 史芳芳, 周孟焦, 崔仕远, 等. 涪城麦冬的拉曼光谱分析[J]. 中医药导报, 2020, 26(9):34
SHI FF, ZHOU MJ, CUI SY, et al. Raman spectroscopic analysis of Maidong(Ophiopogon japonicus) in Fucheng[J]. Guiding J Tradit Chin Med Pharm, 2020, 26(9):34
[26] WU C, LI TY, LI DJ, et al. Rapid detection of pesticide residues in Chinese herbal medicines by molecularly imprinted membrane electrospray ionization mass spectrometry[J]. Chin Chem Lett, 2020, 32(7):2174
[27] 邓群, 郎涛, 夏建新. 药用植物资源开发利用现状及其发展[J]. 中央民族大学学报(自然科学版), 2016, 25(1):55
DENG Q, LANG T, XIA JX. Present situation and development of medicinal plant resources’ utilization[J]. J Minzu Univ China(Nat Sci Ed), 2016, 25(1):55
[28] BODELON G, PASTROIZA SI. Recent progress in surface-enhanced Raman scattering for the detection of chemical contaminants in water[J]. Front Chem, 2020, 8: 478
[29] TADESSE LF, SAFIR F, HO CS, et al. Toward rapid infectious disease diagnosis with advances in surface-enhanced Raman spectroscopy[J]. J Chem Phys, 2020, 152(24):240902
[30] ALAK AM, VODINH TJA. Surface-enhanced Raman spectrometry of organo phosphorus chemical agents[J]. Anal Chem, 1987, 59(17):2149
[31] 林佳. 基于表面增强拉曼散射光谱技术的玉屏风散方剂研究[D].福州: 福建师范大学, 2016
LIN J. Surface-enhanced Raman Scattering Spectroscopic Analysis of Yu-Ping-Feng San Decoction[D]. Fuzhou: Fujian Normal University, 2016
[32] 俞允, 何雁, 陈荣, 等. 基于拉曼光谱的不同产地黄芪鉴别研究[J]. 江西中医药大学学报, 2015, 27(3):57
YU Y, HE Y, CHEN R, et al. Discrimination of Radix Astragali seu Hedysari from different producing areas using Raman spectroscopy[J]. J Jiangxi Univ Tradit Chin Med, 2015, 27(3):57
[33] EDWARDS HG, MUNSHI T, PAGE K. Analytical discrimination between sources of ginseng using Raman spectroscopy[J]. Anal Bioanal Chem, 2007, 389(7-8):2203
[34] 熊平, 郭萍, 周群. 草乌的拉曼光谱分析[J]. 光谱学与光谱分析, 2002, 22(3):417
XIONG P, GUO P, ZHOU Q. The Analysis of Radix Aconiti Kusnezoffii by FT-Raman spectra[J]. Spectrosc Spect Anal, 2002, 22(3):417
[35] 雷咪, 陈龙, 黄必胜, 等. 6种含硫酸盐的矿物类中药及其部分炮制品的拉曼光谱鉴别研究[J]. 中华中医药杂志, 2016, 31(7):2811
LEI M, CHEN L, HUANG BS, et al. Differentiation of six kinds of traditional Chinese medicine containing sulfate and their processed products by Raman spectrometry[J]. China J Tradit Chin Med Pharm, 2016, 31(7):2811
[36] 袁明洋, 雷福汉, 石新华, 等. 玄明粉炮制方法考证及其拉曼光谱研究[J]. 中国药师, 2017, 20(4):643
YUAN MY, LEI FH, SHI XH, et al. Researches on the processing methods and Raman spectroscopy of Matrii Sultas Exsiccatus[J]. China Pharm, 2017, 20(4):643
[37] 明小芳, 尚祥伟, 张超, 等. 纳米雄黄酸水飞品X射线衍射及拉曼光谱分析[J]. 中国实验方剂学杂志, 2018, 24(20):89
MING XF, SHANG XW, ZHANG C, et al. X-ray diffraction and Raman spectrum of nanoparticles processed[J]. Chin J Exp Tradit Med Form, 2018, 24(20):89
[38] CHEN YG, HE XLS, HUANG JH, et al. Impacts of heavy metals and medicinal crops on ecological systems, environmental pollution, cultivation, and production processes in China[J]. Ecotoxicol Environ Saf, 2021, 219: 112336
[39] HE L, BAI L, SHAN LN, et al. Variations in fungal microbiota and aflatoxin contamination during the processing of Yuanzhi, a traditional Chinese medicine[J]. Ind Crops Prod, 2020, 152: 112509
[40] 胡淑荣, 应光耀, 胡玉莉, 等. 赭曲霉毒素A快速检测方法研究进展及其在中药中的应用前景[J]. 中国中药杂志, 2017, 42(11):2032
HU SR, YING GY, HU YL, et al. Research progress in rapid detection of ochratoxin A and its application prospects in traditional Chinese medicine[J]. China J Chin Mater Med, 2017, 42(11):2032
[41] 崔晓慧. 基于XRD、NIRS和Raman光谱技术的硼砂系统鉴别和硼砂等4种中药钴辐照的稳定性研究[D]. 武汉: 湖北中医药大学, 2018
CUI XH. The Systematic Identification of Borax Based on XRD, NIRS and Raman Spectroscopy and the Study on the Stability of Cobalt Irradiation from 4 Kind of Traditional Chinese Medicines Such as Borax[D]. Wuhan: Hubei University of Traditional Chinese Medicine, 2018
[42] WENG SZ, ZHU WX,LI P, et al. Dynamic surface-enhanced Raman spectroscopy for the detection of acephate residue in rice by using gold nanorods modified with cysteamine and multivariant methods[J]. Food Chem, 2020, 310: 125855
[43] LUSSIER F, BRULE T, BOURQUE MJ, et al. Dynamic SERS nanosensor for neurotransmitter sensing near neurons[J]. Faraday Discuss, 2017, 205: 387
[44] 任菲, 于治国, 陆峰. 薏苡仁中黄曲霉毒素G1的动态表面增强拉曼光谱检测[J]. 分析测试学报, 2021, 40(4):612
REN F, YU ZG, LU F. Detection of aflatoxin G1 in Coix seed by dynamic surface-enhanced Raman spectroscopy[J]. J Instrum Anal, 2021, 40(4):612
[45] 杨方, 钟莹, 周鸿昆, 等. 基于表面增强拉曼光谱技术的陈皮年份检测[J]. 激光与光电子学进展, 2017, 54(3):302
YANG F, ZHONG Y, ZHOU HK, et al. Detection of years of dried tangerine peels based on surface-enhanced Raman spectroscopy[J]. Laser Optoelectron Prog, 2017, 54(3):302
[46] 陈秋媚, 张琼, 黄维, 等. 中药复方S洗剂不同保存环境下的激光拉曼光谱分析[J]. 时珍国医国药, 2021, 32(1):82
CHEN QM, ZHANG Q, HUANG W, et al. Laser Raman spectroscopy analysis of Chinese medicine compound S lotion in different storage environment[J]. Lishizhen Med Mater Med Res, 2021, 32(1):82
[47] 胡然, 陆峰, 卞筱泓, 等. MIP-SERS技术快速检测中药中非法添加的茶碱[J]. 分析测试学报, 2017, 36(7):902
HU R, LU F, BIAN XH, et al. Rapid detection of theophylline illegally mixed in traditional Chinese medicine by MIP-SERS[J]. J Instrum Anal, 2017, 36(7):902
[48] 韩丽, 张芳, 张定堃, 等. 中药制剂含量均匀度的测定方法初探[J]. 中草药, 2014, 45(15):2125
HAN L, ZHANG F, ZHANG DK, et al. Determination methods of content uniformity in preparations of Chinese materia medica[J]. Chin Tradit Herb Drugs, 2014, 45(15):2125
[49] 连文慧, 韩晓霞, 惠歌, 等. 基于拉曼光谱和分子模拟技术研究中药小分子与细胞色素C的相互作用[C]// 第二十届全国光散射学术会议(CNCLS 20)论文摘要集, 苏州:长春中医药大学吉林省人参科学研究院, 2019: 1
LIANG WH, HAN XX, HUI G, et al. Study on the interaction between small molecules of traditional Chinese medicine and cytochrome C based on Raman spectroscopy and molecular simulation technology[C]// The 20th National Light Scattering Conference (CNCLS 20) Collection of Abstracts of Papers, Suzhou: Jilin Inslitute of Ginseng Science, Changchun University of Chinese Medicine, 2019: 1
[50] 蔡何青, 赵燕平, 朱伟玲, 等. 拉曼光谱研究丹参注射液对人红细胞膜作用及机制讨论[J]. 中国中药杂志, 2012, 37(10):1467
CAI HQ,ZHAO YP,ZHU WL, et al. Raman spectroscopic study on effect of Danshen injection on human erythrocyte membranes and its mechanism[J]. China J Chin Mater Med, 2012, 37(10):1467
Outlines

/