Objective: To establish the GC fingerprint of volatile components in Xiaojin pills, Xiaojin capsules and Xiaojin tablets, and establish the quality control method of volatile components in Xiaojin series preparations based on extracted characteristic information by data analysis and mining. Methods: GC analysis was performed on an Aligent column(30 m×0.25 mm, 25 μm). The column temperature was programmed to start at 120 ℃, rise to 220 ℃ at a rate of 3 ℃·min-1, maintain for 20 min, rise to 250 ℃ at a rate of 6 ℃·min-1, and maintain for 5 min.The inlet temperature was 220 ℃ and the detector temperature was 250 ℃. Results: The methodological results of the fingerprint met the requirements. The similarities between 42 batches of samples were between 0.70 and 0.99. The key peaks were identified and attributed by GC-MS. Based on similarity data, 6 characteristic peaks were extracted. The relative retention time of the characteristic peaks of 42 batches of samples and the reference peaks were analyzed. Among them, 35 batches of samples were within ±5% of the specified value, and other 7 batches of samples were out of range, indicating quality problem. Conclusion: The method of GC fingerprint/characteristic chromatography of Xiaojin series preparations is simple and accurate,which can be used for the quantity control of volatile components in Xiaojin pills, Xiaojin capsules and Xiaojin tablets.
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