Objective: To establish an 19F quantitative nuclear magnetic resonance(19F qNMR) method for the determination of escitalopram oxalate and its impurities reference substance. Methods: Using 4-fluorocinnamic acid as the internal standard and DMSO as the solvent, 19F NMR spectra were obtained by Bruker Avance NEO 600 spectrometer to measure the content of escitalopram oxalate and its impurities. Results: This method had a good linear relationship, high precision and good repeatability for determination of escitalopram oxalate and its impurities. The contents of reference substances for escitalopram oxalate and its impurities Ⅰ, Ⅱ, Ⅳ and Ⅳ were 99.40%, 99.35%, 96.59%, 97.02% and 90.36% respectively using 19F qNMR method. Conclusion: The 19F qNMR method can be used to determine the contents of escitalopram oxalate and its impurities, and the method is accurate, simple, efficient, economic and environmental friendly.
ZHOU Xiao-li, CHEN Hua
. Study on the determination method of escitalopram oxalate and its impurities reference substance by 19F qNMR[J]. Chinese Journal of Pharmaceutical Analysis, 2023
, 43(5)
: 895
-901
.
DOI: 10.16155/j.0254-1793.2023.05.21
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