SONG Shu-yi, LAN Xian-ming, XU Jing, CUI Yi-fang, ZHOU Hong-yan, ZHENG Jian, DAI Sheng-yun, ZHANG Jia-yu . Systematic analysis and identification of diterpenoid alkaloids from Aconitum carmichaeli Debx. by UHPLC-Q-Exactive Orbitrap MS^*[J]. Chinese Journal of Pharmaceutical Analysis, 2023 , 43(6) : 918 -929 . DOI: 10.16155/j.0254-1793.2023.06.02

[1] 徐硕, 梁晓丽, 李琼, 等. 中药附子的研究进展[J].西北药学杂志, 2017, 32(2):248
XU S, LIANG XL, LI Q, et al. Advances on Chinese herbal medicine Aconiti Lateralis Radix Praeparata[J].Northwest Pharm J, 2017, 32(2):248
[2] 袁雯. 附子的药理研究[J].中医临床研究, 2018, 10(4):145
YUAN W. A research on the pharmacological action of Aconitum carmichaeli Debx.(Fuzi)[J].Clin J Tradit Chin Med, 2018, 10(4):145
[3] 程显隆, 白宗利, 肖新月, 等. 乌头类制品中3个双酯型生物碱的RRLC-MS/MS法分析[J].药物分析杂志, 2010, 30(9):1646
CHENG XL, BAI ZL, XIAO XY, et al. RRLC-MS/MS simultaneous determination of 3 diester diterpenoid alkaloids in processed products of Aconitum[J].Chin J Pharm Anal, 2010, 30(9):1646
[4] 陈思, 李武宏, 陈啸飞, 等. 附子生物碱化学成分和质量控制的研究进展[J].药物分析杂志, 2014, 34(10):1709
CHEN S, LI WH, CHEN XF, et al. Research progress of components and quality control analysis of alkaloids in Aconitum carmichaeli Debx.(Fuzi)[J].Chin J Pharm Anal, 2014, 34(10):1709
[5] 斯琴巴特尔, 席琳图雅, 青格勒, 等. 附子生物碱类化学成分的研究进展[J].世界最新医学信息文摘, 2019, 19(98):50
SI-QIN-BA-TE-ER, XI-LIN-TU-YA, QING-GE-LE, et al. Research progress on chemical constituents of Aconitum carmichaeli Debx.[J].World Latest Med Inform, 2019, 19(98):50
[6] 王建玲, 吴金松. 分析化学样品前处理技术进展分析[J].山东化工, 2021, 50(13):73
WANG JL, WU JS. Advances in analytical chemical sample pretreatment technology[J].Shandong Chem Ind, 2021, 50(13):73
[7] 程实, 赵小宁, 孙巍, 等. 国内外中草药吡咯里西啶类生物碱控制情况浅析[J].中医药学报, 2021, 49(3):87
CHENG S, ZHAO XN, SUN W, et al. Control analysis of pyrrolizidine alkaloids in Chinese herbal medicines home and abroad[J].J Chin Med Pharmacol, 2021, 49(3):87
[8] 杜海丽. 用于液质联用定量分析的化学计量学方法与应用研究[D].长沙:湖南大学, 2014
DU HL. Research on the Theory and Applications of Chemometric Methods for Quantitative Liquid Chromatography-Mass Spectrometry[D].Changsha:Hunan University, 2014
[9] 陈明曦, 李艳梅, 孙婷, 等. 液相色谱-质谱联用技术在中药质量研究中的应用[J].中国药剂学杂志, 2021, 19(1):12
CHEN MX, LI YM, SUN T, et al. Application of liquid chromatography/mass spectrometry in quality research of traditional Chinese medicine[J].Chin J Pharm, 2021, 19(1):12
[10] 李浩然, 董萍萍, 李华健, 等. 基于UHPLC-Q-Exactive Orbitrap MS/MS快速分析开心散物质基准中的化学成分[J].中国中药杂志, 2022, 47(4):938
LI HR, DONG PP, LI HJ, et al. Based on UHPLC-Q-Exactive Orbitrap MS/MS technology to quickly analyze the chemical composition of the Kai-Xin-San substance standard[J].China J Chin Mat Med, 2022, 47(4):938
[11] 熊佩, 李凯琳, 龚开妍, 等. 基于UHPLC-Q-Exactive Orbitrap MS技术的血藤果化学成分分析[J].中国药业, 2021, 30(18):55
XIONG P, LI KL, GONG KY, et al. ldentification of chemical constituents in the Kadsura coccinea(Lemaire) A. C. Smith fructus based on UHPLC-Q-Exactive Orbitrap MS[J].China Pharm, 2021, 30(18):55
[12] 范倩, 陈雪冰, 汪玉梅, 等. 基于UPLC-Q-TOF-MS/MS及GNPS技术的炮附片二萜类生物碱成分[J].中山大学学报(自然科学版), 2021, 60(3):30
FAN Q, CHEN XB, WANG YM, et al. Diterpenoid alkaloids of the processed products of Aconiti Lateralis Radix Praeparata based on UPLC-Q-TOF-MS/MS and GNPS[J].Acta Sci Nat Univ Sunyatseni, 2021, 60(3):30
[13] JIANG BY, LIN S, ZHU CG, et al. Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii[J].J Nat Prod, 2012, 75(6):1145
[14] ZHANG N, SONG YL, SONG QQ, et al. Qualitative and quantitative assessments of Aconiti Lateralis Radix Praeparata using high-performance liquid chromatography coupled with diode array detection and hybrid ion trap-time-of-flight mass spectrometry[J].J Chromatogr Sci, 2016, 54(6):888
[15] XIONG L, PENG C, XIE XF, et al. Alkaloids isolated from the lateral root of Aconitum carmichaelii[J].Molecules, 2012, 17(8):9939
[16] YU HJ, LIANG TT. A New Alkaloid from the roots of Aconitum carmichaeli Debx.[J].J Chin Chem Soc, 2012, 59(6):693
[17] 张思佳, 刘敏卓, 刘静涵, 等. 附子的化学成分研究[J].药学与临床研究, 2010, 18(3):262
ZHANG SJ, LIU MZ, LIU JH, et al. Chemical constituents of lateral roots of Aconitum carmichaeli Debx.[J].Pharm Clin Res, 2010, 18(3):262
[18] 王蕾, 张先灵, 王鑫, 等. UPLC-MSⁿ法对生川乌、生附片化学成分的比较研究[J].药物分析杂志, 2017, 37(9):1640
WANG L, ZHANG XL, WANG X, et al. Comparative study on unprocessed Aconiti Radix and unprocessed Aconiti Lateralis Radix by UPLC-MSⁿ[J].Chin J Pharm Anal, 2017, 37(9):1640
[19] YUE H, PI ZF, SONG FR, et al. Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESI MS/MSⁿ[J].Talanta, 2009, 77(5):1800
[20] HU R, ZHAO J, QI LW, et al. Structural characterization and identification of C(19)-and C(20)-diterpenoid alkaloids in roots of Aconitum Carmichaeli by rapid-resolution liquid chromatography coupled with time-of-flight mass spectrometry[J].Rapid Commun Mass Spectrom, 2009, 23(11):1619
[21] 王昌利, 杨景亮, 雷建林, 等. 附子炮制机理及制品药效毒理研究[J].现代中医药, 2009, 29(1):53
WANG CL, YANG JL, LEI JL, et al. Mechanism of radix Aconitum carmichaeli processing and drug action and toxicity[J].Mod Tradit Chin Med, 2009, 29(1):53
[22] 魏旭雅, 邱子栋, 陈金龙, 等. 有毒乌头类中药炮制与配伍减毒机制的研究进展[J].中国中药杂志, 2019, 44(17):3695
WEI XY, QIU ZD, CHEN JL, et al. Research advancement in mechanisms of processing and compatibility for detoxication of Aconitums[J].China J Chin Mat Med, 2019, 44(17):3695
[23] 刘帅, 刘晓艳, 李妍, 等. 草乌及其炮制品的急性毒性实验研究[J].中国药物警戒, 2015, 12(9):513
LIU S, LIU XY, LI Y, et al. Experimental study on acute toxicity of the Aconitum kusnezoffii Reichb. and its processed products[J].Chin J Pharmacov, 2015, 12(9):513
[24] 张定堃, 赵志浩, 李春雨, 等. 基于生物毒效检测的附子不同炮制品质量评价研究[J].药学学报, 2019, 54(12):2169
ZHANG DK, ZHAO ZH, LI CY, et al. Quality evaluation of different processed products of Aconiti Lateralis Radix Praeparata combining bioassay and toxicity detection[J].Acta Pharm Sin, 2019, 54(12):2169