Objective: To establish a method for the detection and identification of a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP. Method: The samples were analyzed by GC-MS, UPLC-QTOF MS (solvent was methanol), and nuclear magnetic resonance spectrometry (solvent was deuterated methanol). Result: According to the UPLC-QTOF-MS data, the accurate protonated molecule [M+H]+ was m/z 264.175 92 (C16H23FNO+). The main characteristic ions by GC-MS were:m/z 126 (base peak), 109, 137. By the GC-MS and UPLC-QTOF MS data, the compounds could be one of two isomer substances 4-F-3-Me-ɑ-PVP and 3-F-4-Me-ɑ-PVP. After further structure analysis by NMR, the sample was confirmed as a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP. Conclusion: The multi-technique combined method established in this study can be used for the detection and identification of 4-F-3-Me-ɑ-PVP. The method is intuitive, clear, reliable and practical.
WANG Kua-dou, YUAN Xiao-liang, HE Si-yang, SHENG Zhen-hai, LIU Wen-bin, CAO Fang-qi
. Identification of a new psychoactive substance of synthetic cathinone named 4-F-3-Me-ɑ-PVP*[J]. Chinese Journal of Pharmaceutical Analysis, 2023
, 43(6)
: 950
-956
.
DOI: 10.16155/j.0254-1793.2023.06.05
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