Objective: To establish a method for the detection and identification of a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP. Method: The samples were analyzed by GC-MS, UPLC-QTOF MS (solvent was methanol), and nuclear magnetic resonance spectrometry (solvent was deuterated methanol). Result: According to the UPLC-QTOF-MS data, the accurate protonated molecule [M+H]+ was m/z 264.175 92 (C16H23FNO+). The main characteristic ions by GC-MS were:m/z 126 (base peak), 109, 137. By the GC-MS and UPLC-QTOF MS data, the compounds could be one of two isomer substances 4-F-3-Me-ɑ-PVP and 3-F-4-Me-ɑ-PVP. After further structure analysis by NMR, the sample was confirmed as a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP. Conclusion: The multi-technique combined method established in this study can be used for the detection and identification of 4-F-3-Me-ɑ-PVP. The method is intuitive, clear, reliable and practical.
WANG Kua-dou, YUAN Xiao-liang, HE Si-yang, SHENG Zhen-hai, LIU Wen-bin, CAO Fang-qi
. Identification of a new psychoactive substance of synthetic cathinone named 4-F-3-Me-ɑ-PVP*[J]. Chinese Journal of Pharmaceutical Analysis, 2023
, 43(6)
: 950
-956
.
DOI: 10.16155/j.0254-1793.2023.06.05
[1] SCHIAVI S, MELANCIA F, CARBONE E, et al. Detrimental effects of the‘bath salt’methylenedioxy-pyrovalerone on social play behavior in male rats[J].Neuropsychopharmacol, 2020, 45(12):2012
[2] 沈敏. 新精神活性物质的应对与挑战[J].法医学杂志,2021,37(4):453
SHEN M. The Response and challenge of new psychoactive substances[J].J Forensic Med, 2021,37(4):453
[3] PIEPRZYCA E, SKOWRONEK R, NIŽNANSKY L, et al. Synthetic cathinones-From natural plant stimulant to new drug of abuse[J].Eur J Pharmacol,2020,875(173012):1
[4] KESHA K, BOGGS CL, RIPPLE MG, et al. Methylenedioxypyrovalerone(“bath salts”),related death: case report and review of the literature[J].J Forensic Sci,2013,58(6):1654
[5] MAGEE CP, GERMAN CL, SIRIPATHANE YH, et al. 3,4-methylenedioxypyrovalerone:neuro-pharmacological impact of a designer stimulant of abuse on monoamine transporters[J].J Pharmacol Exp Ther,2020,374(2):273
[6] PATOCKA J, ZHAO B, WU W, et al. Flakka: new dangerous synthetic cathinone on the drug scene[J].Int J Mol Sci, 2020, 21(21):8185
[7] ZWARTSEN A, OLIJHOEK ME, WESTERINK RHS, et al. Hazard characterization of synthetic cathinones using viability,monoamine reuptake,and neuronal activity assays[J].Front Neurosci, 2020, 14(9):1
[8] 蔡衡横,刘鑫. 新精神活性物质发展与管制综述[J].中国法医学杂志 2021, 36(1):14
CAI HH, LIU X. Development and control on new psychoactive substances:a systematic review[J].Chin J Forensic Med, 2021, 36(1):14
[9] 黄志斌,蔡娟,林泽彬,等. 合成卡西酮类新精神活性物质对动物行为学影响的研究进展[J].法医学杂志,2021,37(4):561
HUANG ZB, CAI J, LIN ZB, et al. Research progress on the effect of synthetic cathinones on animal behavior[J].J Forens Med,2021,37(4):561
[10] COUTO RAS, GONÇALVES LM, CARVALHO F, et al. The analytical challenge in the determination of cathinones, key-players in the worldwide phenomenon of novel psychoactive substances, Crit. Rev[J].Anal Chem,2018,48(5):372
[11] GONCALVES JL, ALVES VL, AGUIAR J, et al. Synthetic cathinones:an evolving class of new psychoactive substances[J].Crit Rev Toxicol, 2019, 49:549
[12] WANG KD, YUAN XL, LIU C, et al. Identification of three novel new psychoactive substances 4F-AB-BUTINACA, AB-PHETINACA, and 2F-NENDCK[J].Drug Test Anal, 2022, 14(8):1
[13] LIU CM, HUA ZD,JIAEI W, et al. Identification of AD-18, 5F-MDA-19, and pentyl MDA-19 in seized materials after the class-wide ban of synthetic cannabinoids in China[J].Drug Test Anal, 2022, 14:307
[14] 王跨陡, 袁晓亮, 张玉荣, 等. 合成大麻素类新精神活性物质4F-MDMB-BUTINACA和MDMB-4en-PINACA的检测[J].法医学杂志, 2021, 37(4):505
WANG KD, YUAN XL, ZHANG YR, et al. Identification of synthetic cannabinoid new psychoactive substances 4F-MDMBBUTINACA and MDMB-4en-PINACA[J].J Forens Med, 2021, 37(4):505
[15] QIAN ZH, JIA W, LI T, et al. Identification and analytical characterization of four synthetic cannabinoids ADB-BICA, NNL-1,NNL-2, and PPA(N)-2201[J].Drug Test Anal, 2017, 9:51
