[1] BOONYASIRI A, JAUNEIKAITE E, BRINKAC LM, et al. Genomic and clinical characterisation of multidrug-resistant carbapenemase-producing ST231 and ST16 Klebsiella pneumoniae isolates colonising patients at Siriraj hospital, Bangkok, Thailand from 2015 to 2017[J].BMC Infect Dis, 2021, 21(1):142
[2] PACZOSA MK, MECASAS J, KLEBSIELLAP. Klebsiella pneumoniae: going on the offense with a strong defense.[J].Microbiol Mol Biol Rev, 2016, 80(3): 629
[3] KOLLEF MH,BURNHAM CD. Ventilator-associated pneumonia: the role of emerging diagnostic technologies[J].Semin Respir Crit Care Med, 2017, 38(3): 253
[4] WANG JJ, DOU XJ, SONG J, et al. Antimicrobial peptides: promising alternatives in the post feeding antibiotic era[J].Med Res Rev,2019,39(3):831
[5] 郭娜,肖向红,徐义刚,等.东北林蛙皮肤抗菌肽dyskinbow-1ST的表达、纯化及抑菌活性分析[J].中国农业科学,2011,44(15):3246
GUO N, XIAO XH, XU YG, et al Expression, purification and antimicrobial activity analysis of skin antimicrobial peptide dyskinbow-1st from Rana chensinensis[J].China Agric Sci, 2011, 44 (15): 3246
[6] HUANG XX, GAO CY, ZHAO QJ, et al. Antimicrobial characterization of site-directed mutagenesis of porcine beta defensin 2[J].PLOS ONE,2015,10(2):e0118170
[7] JIANG XF, QIAN K, LIU GP, et al. Design and activity study of a melittin-thanatin hybrid peptide[J].AMB Express,2019,9(1):14
[8] CHAN LY, GUNASEKERA S, HENRIQUES ST, et al. Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds[J].Blood, 2011, 118(25): 6709
[9] DONG N, WANG ZH, CHOU SL, et al. Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1[J].Chem Biol Drug Design, 2018, 91(5):1017
[10] 翟培,韩晋辉,潘晓瑜.基于天蚕素A和胡蜂毒素的杂合肽设计及活性鉴定[J].中国畜牧兽医,2020,47(9):3006
ZHAI P, HAN JH, PAN XY. Design and activity identification of hybrid peptides based on Cecropin A and wasp toxin[J] China Animal Husbandry Veter, 2020, 47 (9): 3006
[11] YANG Y, WU D, WANG CH, et al. Hybridization with insect Cecropin A (1-8) improve the stability and selectivity of naturally occurring peptides[J].International Journal of Molecular Sciences, 2020, 21(4):1470
[12] CHEN D, ZHOU XW, CHEN X, et al. Evaluating the Bioactivity of a novel antimicrobial and anticancer peptide dermaseptin-PS4(Der-PS4) from the skin secretion of Phyllomedusa sauvagii[J].Molecules, 2019, 24(16):2974
[13] LEE EJ, JEONG KW, LEE J, et al. Structure-activity relationships of cecropin-like peptides and their interactions with phospholipid membrane[J].BMB Reports,2013,46(5):282
[14] JIANG ZQ, VASIL AI, HALE J, et al. Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides[J].Adv Exper Med Biol, 2009, 6(11):561
[15] ARTUR S, MUKESH P, MARTIN M. Effect of hydrophobic modifications in antimicrobial peptides[J].Adv Colloid Interface Sci, 2014, 205:265
[16] NIKKEN W, MAJAD K. Rationally designed α-helical broad-spectrum antimicrobial peptides with idealized facial amphiphilicity[J].Macromol Rapid Commun, 2013, 34(1):74
[17] MIAO XK, ZHOU TX, ZHANG JY, et al. Enhanced cell selectivity of hybrid peptides with potential antimicrobial activity and immunomodulatory effect[J]. Biochim Biophys Acta Gen Subj, 2020, 1864(4): 129532.
[18] 枚春成. 二级结构对抗菌肽的抗菌活性及特异性的影响[D].长春:吉林大学,2013
MEI CC. Effect of Secondary Structure on Antibacterial Activity and Specificity of Antimicrobial Peptides[D].Changchun:Jilin University, 2013
[19] 袁德峥. 黑龙江林蛙皮抗菌肽dyskinbow-2CAMa的表达及抗菌活性的初步研究[D].沈阳:辽宁大学,2011
YUAN DZ. Expression and Antibacterial Activity of Antimicrobial Peptide dyskinbow-2 CAMA in Heilongjiang Forest Frog Skin[D].Shenyang:Liaoning University, 2011
[20] Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement[S].CLSI Document M100-S24. Wayne, PA, Clinical and Laboratory Standards Institute, 2014: 94
[21] 王兵,杜兵,韦鹏威,等.原核表达家蝇Phormicin蛋白对金黄色葡萄球菌的抑菌活性分析[J].基因组学与应用生物学,2020,39(12):5533
WANG B, DU B, WEI PW, et al Antimicrobial activity of prokaryotic expression of Musca domestica phormicin protein against Staphylococcus aureus[J].Genom Appl Biol, 2020, 39 (12): 5533
[22] 钟亨任. 海南沼蛙Temporin及Brevinin抗菌肽对革兰氏阳性菌生物被膜的抑制作用[D].海口:海南大学,2019
ZHONG HR. Inhibitory Effects of Temporin and Brevinin Antimicrobial Peptides of Hainan Swamp Frog on Gram-Positive Bacterial Biofilm[D]. Haikou:Hainan University, 2019
[23] ZHANG MJ, WEI W, SUN YG, et al. Pleurocidin congeners demonstrate activity against Streptococcus and low toxicity on gingival fibroblasts[J]. Arch Oral Biol, 2016, 70: 79
[24] FRANCISCO RF, STEFAN DF, KATELYN EC, et al. Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains[J].Drug Devel Res, 2020, 81(1):43
[25] AGEITOS JM, SANCHEZ PA, CALO MP, et al. Antimicrobial peptides (AMPs): ancient compounds that represent novel weapons in the fight against bacteria[J].Biochem Pharmacol, 2017, 133: 117
[26] SUN JB, XIA YQ, LI D, et al. Relationship between peptide structure and antimicrobial activity as studied by de novo designed peptides[J].Biochim Biophys Acta, 2014, 1838(12):2985
[27] AXEL H, MELINA M, MARTíN EN, et al. Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptide-membrane interactions of three related antimicrobial peptides[J].Colloids Surfaces B: Biointerfaces, 2016, 141:528
[28] WANG M, LIN JL, SUN QL, et al. Design, expression, and characterization of a novel cecropin A-derived peptide with high antibacterial activity[J].Springer Berlin Heidelberg, 2019, 103(4):1765
[29] SCHMIDTCHEN A, PASUPULETI M, MALMSTEN M. Effect of hydrophobic modifications in antimicrobial peptides[J].Adv Colloid Interface Sci,2014,205(12): 265
[30] YEAMAN MR, YOUNT NY. Mechanisms of antimicrobial peptide action and resistance.[J].Pharmacol Rev,2003,55(1):27
[31] 徐欣瑶, 董娜, 李欣然, 等.不同疏水性氨基酸对α-螺旋抗菌肽生物学活性的影响[J].畜牧兽医学报,2019,50(4):791
XU XY, DONG N, LI XR, et al. Different hydrophobic amino acid pairs α-effect of helical antimicrobial peptides on biological activity[J].Chin J Anim Vet Sci, 2019, 50 (4): 791
[32] MÓNICA FV, SAJITH J, ALEXEY SL, et al. Folding amphipathic helices into membranes: amphiphilicity trumps hydrophobicity[J].J Molec Biol, 2007, 370(3):459
[33] 董天堂, 田子罡, 王建华. α-螺旋型抗菌肽结构参数与功能活性的关系[J].中国生物工程杂志,2007,27(9):116
DONG TT, TIAN ZG, WANG JH. α-Relationship between structural parameters and functional activity of helical antimicrobial peptides[J].Chin J Bioengin, 2007,27 (9): 116
[34] PATHAK N,SALAS AR,RUCHE G, et al. Comparison of the effects of hydrophobicity, amphiphilicity, and alpha-helicity on the activities of antimicrobial peptides[J].Proteins, 1995, 22(2): 182
[35] COOK LC, DUNNY GM. Effects of biofilm growth on plasmid copy number and expression of antibiotic resistance genes in Enterococcus faecalis[J].Antimicrob Agents Chemother, 2013, 57 (4):1850
[36] DAVIS RT, BROWN PD. SpoT-mediated stringent response influences environmental and nutritional stress tolerance, biofilm formation and antimicrobial resistance in Klebsiella pneumoniae[J].APMIS, 2020, 128(1): 48
[37] BLACKLEDGE MS, WORTHINGTON RJ, MELANDER C. Biologically inspired strategies for combating bacterial[J].Biofilms Curr Opin Pharmacol, 2013, 13(5): 699
