Safety Monitoring

Determination and primary risk evaluation of 31 inorganic elements in Lindera aggregata(Sims) Kosterm. from different habitat and medication part

Expand
  • 1. Zhejiang Pharmaceutical College, Ningbo 315500, China;
    2. Zhejiang Chinese Medical University, Hangzhou 315053, China;
    3. Changzhou Institute for Food, Drug and Fiber Control, Changzhou 213001, China

Received date: 2021-04-07

  Online published: 2024-06-26

Abstract

Objective: To analyze the contents of 31 inorganic elements in Lindera aggregate (Sims) Kosterm. (L. aggregata), and to perform the risk evaluation and the theoretical limits for 5 heavy metals and harmful elements in order to provide reference for quality assurance. Methods: The contents of 31 inorganic elements were determined by inductively coupled plasma mass spectrometry (ICP-MS), the risk of heavy metals and harmful elements were assessed deterministically by the methods of hazardous index (HI), and the theoretical limits for heavy metals and harmful elements were calculated. Results: The determination results of 31 kinds of inorganic elements all had a good linear relationship with r≥0.994 1. The recoveries were 88.7%-104.1% with RSDs≤3.6%. The risk assessment results showed that the risk of 5 heavy metals and harmful elements in different parts of L. aggregata was controllable, and HIs were all below 1. After calculation, the actual measured values of Hg, Cu and As in different samples were far less than the theoretical limits. Except for the leaves of L. aggregata from Tiantai, contents of other samples exceeded the limit of Cd. The contents of Pb in the samples exceeded the limit, and the contents of Pb in the root tubers and taproots from Shaoguan, Guangdong Province exceeded the limit. Conclusion: This method can be used for the determination of inorganic elements in different parts of L. aggregata, and is suitable for the risk assessment of heavy metals and harmful elements in L. aggregata, which provides a basis for the quality control and safety evaluation of L. aggregata.

Cite this article

LUO Yi-yuan . Determination and primary risk evaluation of 31 inorganic elements in Lindera aggregata(Sims) Kosterm. from different habitat and medication part[J]. Chinese Journal of Pharmaceutical Analysis, 2022 , 42(3) : 424 -432 . DOI: 10.16155/j.0254-1793.2022.03.09

References

[1] 中华人民共和国药典2020年版.一部[S].2020:79
ChP 2020.Vol Ⅰ[S].2020:79
[2] 李平. 新“浙八味”将为相关中药材产业带来什么[N].台州日报, 2018-03-09(4).
LI P. What will the new "ZHEBAWEI" bring to the related Chinese medicinal materials industry [N].Taizhou Daily(台州日报), 2018-03-09(4)
[3] LIU ZL, CHU SS, JIANG CH, et al. Composition and insecticidal activity of the essential oil of Lindera aggregata root tubers against Sitophilus zeamais and Tribolium castaneum[J].J Essential Oil Bear Plants, 2016, 19(3):727
[4] 程慧洁, 蔡夏琴, 项家席, 等. 乌药块根与叶药用价值探析[J].浙江中西医结合杂志, 2014, 24(6):563-565.
CHENG HJ, CAI XQ, XIANG JX, et al. Study on the medicinal value of root and leaf of Lindera aggregata (Sims) Kosterm.[J].Zhejiang J Integr Tradi Chin West Med, 2014, 24(6):563
[5] 邢梦雨, 田崇梅, 夏道宗. 乌药化学成分及药理作用研究进展[J].天然产物研究与开发, 2017, 29(12):2147
XING MY, TIAN CM, XIA DZ. Review on chemical constituents and pharmacological effects of Lindera aggregata Kosterm.[J].Nat Prod Res Dev, 2017, 29(12):2147
[6] WU Y, ZHENG Y, LIU X, et al. Separation and quantitative determination of sesquiterpene lactones in Lindera aggregata (wu-yao) by ultra-performance LC-MS/MS[J].J Sep Sci, 2015, 33(8):1072
[7] 洪浩,杜伟锋,康显杰, 等.基于UPLC-Triple-TOF/MS定性比较乌药块根、直根化学成分[J].中药材, 2020,43(3):615
HONG H, DU WF, KANG XJ, et al. Qualitative comparison of chemical constituents from root and taproot of Lindera aggregata based on UPLC-Triple-TOF MS[J].J Chin Med Mater, 2020, 43(3):615
[8] LIU ZL, CHU SS, Jiang CH, et al. Composition and insecticidal activity of the essential oil of Lindera aggregata root tubers against Sitophilus zeamais and Tribolium castaneum[J].J Essential Oil Bear Plants,2016, 19:727
[9] 颜世铭, 李增禧, 熊丽萍. 微量元素医学精要Ⅰ.微量元素的生理作用和体内平衡[J].广东微量元素科学,2002, 9(9):1
YAN SM, LI ZX, XIONG LP. Essentials of trace element medicine I. physiological role and balance of trace elements in human body[J].Guangdong Trace Elements Sci, 2002, 9(9):1
[10] 左甜甜, 张磊, 石上梅,等. 10 种根和根茎类中药材中重金属及有害元素的风险评估及最大限量理论值[J].药物分析杂志,2020,40(10):1870
ZUO TT, ZHANG L, SHI SM, et al. Risk assessment and theoretical limits for heavy metals and harmful elements in 10 types of root and rhizome Chinese medicinal materials[J].Chin J Pharm Anal, 2020, 40(10):1870
[11] TANG WZ, ZHANG WQ, ZHAO Y, et al. Basin-scalecomprehensive assessment of cadmium pollution, risk, and toxicity in riverine sediments of the Haihe Basin in north China[J].EcolIndic, 2017,81:295
[12] 郭岚,王蕊,柳英霞,等. ICP-AES测定乌药饮片及其煎煮液中无机元素的含量[J].光谱实验室,2011,28(6):2921
GUO L, WANG R, LIU YX, et al. Determination of inorganic elements in Lindera aggregata (Sims) Kosterm piece and its decoctions by ICP-AES[J].Chin J Spectroscopy Lab, 2011, 28(6):2921
[13] 罗益远, 蔡红蝶, 沙秀秀, 等. 天台乌药不同部位挥发性成分的GC-MS分析[J].中药材, 2019, 42(6):1319
LUO YY, CAI HD, SHA XX, et al. GC-MS analysis of volatile components in different parts of TAIWUYAO[J].J Chin Med Mater, 2019,42(6):1319
[14] 罗益远,刘娟秀, 侯娅, 等.何首乌不同产地及商品药材中无机元素的ICP-MS分析[J].中草药,2015,46(7):1056
LUO YY, LIU JX, HOU Y, et al. ICP-MS analysis on inorganic elements in Polygoni multiflori Radix from different habitats and commercial herbs[J].Chin Tradit Herb Drugs, 2015,46(7):1056
[15] 左甜甜, 张磊, 王莹, 等.中药材及饮片中重金属及有害元素限量制定的探讨[J].药物分析杂志, 2020, 40(4):688
ZUO TT, ZHANG L, WANG Y, et al. Exploration of the limit of heavy metals and harmful elements in Chinese medicinal materials and decoction pieces[J].Chin J Pharm Anal, 2020, 40(4):688
[16] 孔丹丹, 李歆悦, 闫卉欣, 等. 药食两用植物药中重金属污染及其健康风险评估模型的建立——以黄芪、党参、昆布为例[J].中国中药杂志, 2019, 44(23):5042.
KONG DD, LI XY, YAN HX, et al.Establishment of health risk assessment model for assessing medicinal andedible plants contaminated by heavy metals—take Astragali Radix, Codonopsis Radix and Laminariae Thallus as examples[J].China J Chin Mater Med, 2019, 44(23):5042
[17] 左甜甜, 金红宇, 余坤子, 等. ICP-MS 法结合化学计量学用于枸杞子道地性的研究及安全性评价[J].药物分析杂志, 2021, 41(3):394
ZUO TT, JIN HY, YU KZ, et al. Holistic strategy of study on authenticity and safety evaluation of Chinese wolfberry by ICP-MS combined with chemometrics[J].Chin J Pharm Anal, 2021, 41(3):394
[18] 袁建民, 何璐, 杨晓琼, 等.香叶天竺葵不同部位中19种无机元素分布规律研究[J].江西农业学报, 2019, 31(11):98
YUAN JM, HE L, YANG XQ, et al. Distribution of 19 inorganic elements in different parts of Pelargonium gravelens[J].Acta Agric Jiangxi, 2019, 31(11):98
[19] 周利, 赵曼茜, 王升, 等. 川芎中无机元素的分布及积累规律[J].中国中药杂志, 2019, 44(9):1793.
ZHOU L, ZHAO MX, WANG S, et al. Distribution and accumulation of inorganic elements in Ligusticum chuanxiong[J].China J Chin Mater Med, 2019, 44(9):1793
Outlines

/