[1] AUERBACH M, MACDOUGALL I.The available intravenous iron formulations : history, efficacy, and toxicology[J].Hemodial Int, 2017, 21(Suppl 1): S83
[2] BHANDARI S, PEREIRA DIA, CHAPPELL HF, et al. Intravenous irons: from basic science to clinical practice[J].Pharmaceuticals (Basel), 2018, 11(3): E82
[3] MACDOUGALL IC.Evolution of iv iron compounds over the last century[J].J Ren Care, 2009, 35(Suppl2): S8
[4] GIRELLI D, UGOLINI S, BUSTI F, et al. Modern iron replacement therapy : clinical and pathophysiological insights[J].Int J Hematol, 2018, 107(1): 16
[5] MANTADAKIS E.Advances in pediatric intravenous iron therapy[J].Pediatr Blood Cancer, 2016, 63(1): 11
[6] WANG LL, WANG LL, SU CY, et al. Characterization and digestion features of a novel polysaccharide-Fe(Ⅲ) complex as an iron supplement[J].Carbohydr Polym, 2020, 249: 116812
[7] KIANPOUR S, EB RAHIMINEZHAD A, DEYHIMI M, et al. Structural characterization of polysaccharide-coated iron oxide nanoparticles produced by Staphylococcus warneri, isolated from a thermal spring[J].J Basic Microbiol, 2019, 59(6): 569
[8] 陈国庆, 先宏.植物多糖类铁复合物的研究进展[J].重庆中草药研究, 2009, 60(2): 38
CHEN GQ, XIAN H.Advances in plant polysaccharide iron complex[J].Chongqing J Res Chin Drugs Herbs, 2009, 60(2): 38
[9] ZHANG JQ, CHEN C, FU X.Fructus mori L. polysaccharide-iron chelates formed by self-embedding with iron(Ⅲ) as the core exhibit good antioxidant activity[J].Food Funct, 2019, 10(6): 3150
[10] XU L, MENG YB, LIU Y, et al. A novel iron supplements preparation from Grifola frondosa polysaccharide and assessment of antioxidant, lymphocyte proliferation and complement fixing activities[J].Int J Biol Macromol, 2018, 108: 1148.
[11] LIU T, LIU TT, LIU HC, et al. Preparation and characterization of a novel polysaccharide-Iron(Ⅲ) complex in Auricularia auricular potentially used as an iron supplement[J].Biomed Res Int, 2019(5): 1
[12] 乌兰格日乐, 安喜明, 王丹, 等.玉米须多糖金属配合物的金属元素含量及对尿素的吸附作用研究[J].药物分析杂志, 2020, 40(5): 933
WU-LAN-GE-RI-LE, AN XM, WANG D, et al. Metal contents of stigma maydis polysaccharide metal complexes and their adsorption to urea[J].Chin J Pharm Anal, 2020, 40(5): 933
[13] 乌兰格日乐, 李永涛, 白海泉, 等.玉竹多糖铁配合物的制备工艺优化及铁含量测定[J].药物分析杂志, 2012, 32(4):571
WU-LAN-GE-RI-LE, LI TY, BAI HQ, et al. Purified preparation of Polygonatum odoratum (Mill.) Druce polysaccharide-Fe (saccharide and assay of Fe(Ⅲ)[J].Chin J Pharm Anal, 2012, 32(4): 571
[14] 史琛, 张玉, 王凯平.当归多糖铁胃内滞留缓释片在犬体内的药物动力学研究[J].药物分析杂志, 2011, 31(4): 629
SHI C, ZHANG Y, WANG KP.Study on the pharmacokinetics of Angelica sinensis polysaccharide iron complex floating sustained-release tablets in Beagle dogs[J].Chin J Pharm Anal, 2011, 31(4): 629
[15] 李坷, 陈志祥, 王凯平.当归多糖铁中铁含量测定的不确定度评定[J].药物分析杂志, 2008, 28(4): 586
LI K, CHEN ZX, WANG KP.Evaluation of uncertainty for the determination of iron(Ⅲ) in Angelica sinensis (Oliv.) Diels polysaccharide-iron complex[J].Chin J Pharm Anal, 2008, 28(4): 586
[16] ZOUP, TYNER K, RAW A, et al. Physicochemical characterization of iron carbohydrate colloid drug products[J].AAPS J, 2017, 19(5): 1359
[17] BLANCO E, SHEN H, FERRARI M.Principles of nanoparticle design for overcoming biological barriers to drug delivery[J].Nat Biotechnol, 2015, 33(9): 941
[18] KEATING GM.Ferric carboxymaltose:a review of its use in iron deficiency[J].Drugs, 2015, 75(1): 101
[19] SHOKRG0ZAR N, GOLAFSHAN HA. Molecular perspective of iron uptake, related diseases, and treatments[J].Blood Res, 2019, 54(1):10
[20] BREMNER I, COX JSG, MOSS GF.Structural studies on iron-dextran: characterisation of an alkali-degraded dextran suitable for use in the production of parenteral iron-dextran complexes[J].Carbohydr Res, 1969, 11(1): 77
[21] 李明静, 杨静, 王宁, 等.怀山药多糖铁(Ⅲ)的组成及性能表征[J].中国中药杂志, 2008, 33(16): 2002
LI MJ, YANG J, WANG N, et al.Composition and property characterization of Rhizoma Dioscoreae polysaccharide Fe(Ⅲ) complex[J].China J Chin Mat Med, 2008, 33(16): 2002
[22] 尹玉婷. 虎眼万年青多糖铁(Ⅲ)复合物的制备工艺及其性质结构研究[D].哈尔滨:黑龙江中医药大学, 2014
YIN YT.Research on Preparation Technology, Property and Sturcture of Orithogalum Polysaccharide Iron(Ⅲ) Complex[D]. Haerbing: Heilongjiang University of Chinese Medicine, 2014
[23] 陈志祥. 当归多糖铁复合物的分子结构、分子式及分子量研究[D].武汉:华中科技大学, 2008
CHEN ZX. Molecular Sturcture, Formula Molecular Weight of the Angelica Sinensis Polysaccharide Iron Complex[D]. Wuhan: Huazhong University of Science and Technology, 2008
[24] 李琳. 二色补血草多糖铁(Ⅲ)合成工艺及其性质结构研究[D].西安:西北大学, 2012
LI L.Research on Synthesis, Property and Sturcture of Limonium Bicolor Polysaccharide lron(Ⅲ) Complex[D]. Xi'an: Northwest University, 2012
[25] WU Y, PETROCHENKO P, CHEN L, et al. Core size determination and structural characterization of intravenous iron complexes by cryogenic transmission electron microscopy[J].IntJ Pharm, 2016, 505(1-2): 167
[26] JAHN MR, ANDREASEN HB, FUTTERER S, et al. A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer), a new intravenous iron preparation and its clinical implications[J].Eur J Pharm Biopharm, 2011, 78(3): 480
[27] KUDASHEVA DS, LAI J, ULMAN A, et al. Structure of carbohydrate-bound polynuclear iron oxyhydroxide nanoparticles in parenteral formulations[J].J Inorg Biochem, 2004, 98(11): 1757
[28] BULLIVANT JP, ZHAO S, WILLENBERG BJ, et al. Materials characterzation of feraheme/ferumoxytol and preliminary evaluation of its potential for magnetic fluid hyperthermia[J].Int J Mol Sci, 2013, 14(9): 17501
[29] 唐敏敏. 茶多糖铁复合物的制备及其部分药效研究[D].青岛: 中国海洋大学, 2009
TANG MM.Preparation of Tea Polysaccharides-iron Complex and Study of Its Partial Efficacy[D]. Qingdao: Ocean University of China, 2009
[30] 靳倩. 蔗糖铁复合物合成工艺关键影响因素的研究[D].开封: 河南大学, 2019
JIN Q.Study on the Key Influencing Factors of the Synthesis Process of Iron Sucrose Complex[D]. Kaifeng: Henan University, 2019
[31] GUTIÉRREZ L, MORALES MdP, LÁZARO FJ. Magnetostructural study of iron sucrose[J].J Magn Magn Mater, 2005, 293(1): 69
[32] NEISER S, RENTSCH D, DIPPON U, et al. Physico-chemical properties of the new generation IV iron preparations ferumoxytol, iron isomaltoside 1000 and ferric carboxymaltose[J].Biometals, 2015, 28(4):615
[33] BAROT BS, PAREJIYA PB, MEHTA DM, et al. Physicochemical and structural characterization of iron-sucrose formulations: a comparative study[J].Pharm Dev Technol, 2014, 19(5):513
[34] KORALEWSKI M, POCHYLSKI M, GIERSZEWSKI J.Magnetic properties of ferritin and akaganeite nanoparticles in aqueous suspension[J].J Nanopart Res, 2013, 15: 1902
[35] BHARATHI D, RANJITHKUMAR R, VASANTHARAJ S, et al. Synthesis and characterization of chitosan/iron oxide nanocomposite for biomedical applications[J].Int J Biol Macromol, 2019, 132: 880
[36] FRANKEL RB, PAPAEFTHYMIOU GC, WATT GD. Variation of superparamagnetic properties with iron loading in mammalian ferritin[J].Hyperf Interact, 1991, 66(1-4): 71
[37] FUNK F, LONG GJ, HAUTOT D, et al. Physical and chemical characterization of therapeutic iron containing materials:a study of several superparamagnetic drug formulations with the β-FeOOH or ferrihydrite structure[J].Hyperf Interact, 2001, 136(1-2): 73
[38] SUN D, ROUSE R, PATEL V, et al. Comparative evaluation of U.S. brand and generic intravenous sodium ferric gluconate complex in sucrose injection : physicochemical characterization[J].Nanomaterials, 2018, 8(1): E25
[39] DI FRANCESCO T, DELAFONTAINE L, PHILIPP E, et al. Tron polymaltose complexes : could we spot physicochemical differences in medicines sharing the same active pharmaceutical ingredient ?[J].Eur J Pharm Sci, 2020, 143: 105180
[40] JIA N, QIAO H, ZHU W, et al. Antioxidant, immunomodulatory, oxidative stress inhibitory and iron supplementation effect of Astragalus Membranaceus polysaccharide-iron(Ⅲ) complex on iron-deficiency anemia mouse model[J].Int J Biol Macromol, 2019, 132:213
[41] GAO W, HUANG Y, HE R, et al. Synthesis and characterization of a new soluble soybean polysaccharide-iron(Ⅲ) complex using ion exchange column[J].IntJ Biol Macromol, 2018, 108: 1242
[42] FUTTERER S, ANDRUSENKO I, KOLB U, et al. Structural characterization of iron oxide/ hydroxide nanoparticles in nine different parenteral drugs for the treatment of iron deficiency anaemia by electron diffraction (ED) and X-ray powder diffraction (XRPD)[J].J Pharm Biomed Anal, 2013, 86: 151
[43] BENDERSKY L, GAYLE F.Electron diffraction using transmission electron microscopy[J].J Res Natl Inst Stand Technol, 2001, 106(6): 997
[44] SZY BOWICZ M, KORALEWSKI M, KAROŃ J, et al. Micro-Raman spectroscopy of natural and synthetic ferritins and their mimetics[J].Acta Phys Pol A, 2015, 127:534
[45] ORMEROD RM.Surface Chemistry: electron yield spectroscopy[M]// BUSCHOW KHJ, CAHN RW, FLEMINGS MC, et al. Encyclopedia of Materials: Science and Technology. Oxford: Elsevier, 2001 : 9006
[46] THEIL E, SAYERS D, BROWN M.Similarity of the structure of ferritin and iron dextran (imferon) determined by extended X-ray absorption fine structure analysis[J].J Biolog Chem, 1979, 254: 8132
[47] COE EM, BOWEN LH, SPEER JA, et al. The recharacterization of a polysaccharide iron complex (niferex)[J].J Inorg Biochem, 1995, 58(4): 269.
[48] GOLDANSKII VI, HERBER RH.Chemical Applications of Mössbauer Spectroscopy[M]. New York: Academic Press, 1968
[49] HERBER R.Chemical applications of Mossbauer spectroscopy[J].Annu Rev Phys Chem, 2003, 17:261
[50] 王花. 大枣多糖铁(II)复合物的合成研究[D].西安:西北大学, 2009
WANG H.Research on Synthesis of Jujube Polysaccharide lron(Ⅲ) Complex[D]. Xi'an: Northwest University, 2009
[51] AUERBACH H, GIAMMANCO G, SCHÜNEMANN V, et al. Mössbauer spectroscopic characterization of iron(M)-polysaccharide coordination complexes : photochemistry, biological, and photoresponsive materials implications[J].Inorg Chem, 2017, 56(19): 11524
[52] ISHIKAWA T, NITTA S, KONDO S.Fourier-transform infrared spectroscopy of colloidal a-, β-and γ-ferric oxide hydroxides[J].J Chem Soc Faraday Trans, 1986, 82(8): 2401
[53] HUANG CX, TAO YH, LI M, et al. Synthesis and characterization of an antioxidative galactomannan-iron(I) complex from Sesbania Seed[J].Polymers(Basel), 2018, 11(1): 28
[54] LU Q, XU L, MENY YB, et al.Preparation and characterization of a novel Astragalus Membranaceus polysaccharide-iron (Ⅲ) complex[J].Int J Biol Macromol, 2016, 93: 208
[55] 许丽丽. 玉竹多糖微波提取及其铁复合物的研究[D].杭州:杭州师范大学, 2012
XU LL.Study on Microwave-assisted Extraction of Polygonatum Doratum Polysaccharides and Preparation of POPFe[D]. Hangzhou: Hangzhou Normal University, 2012
[56] CUI JF, LI YP, YU P, et al. A novel low molecular weight Enteromorpha polysaccharide-iron(Ⅲ) complex and its effect on rats with iron deficiency anemia(IDA)[J].Int J Biol Macromol, 2018, 108: 412
[57] LI YP, WANG XP, JIANG YC, et al. Structure characterization of low molecular weight sulfate Ulva polysaccharide and the effect of its derivative on iron deficiency anemia[J].Int J Biol Macromol, 2019, 126: 747
[58] FENG G, ZHANG XF.Production of a codonopsis polysaccharide iron complex and evaluation of its properties[J].Int J Biol Macromol, 2020, 162: 1227
[59] DOBOSZ B, KRZYMINIEWSKI R, SCHROEDER G, et al. Electron paramagnetic resonance as an effective method for a characterization of functionalized iron oxide[J].J Phys Chem Sol, 2014, 75: 594
[60] SUR S, COONEY T.Electron paramagnetie resonance study of iron (II)and manganese(II)in the glassy and crystalline environments of synthetic fayalite and tephroite[J].Phys Chem Minerals, 1989, 16: 693
[61] SOMSOOK E, HINSIN D, BUAKHRONG P, et al.Interactions between iron(I) and sucrose, dextran, or starch in complexes[J].Carbohydr Polym, 2005, 61:281
[62] GEETHA K, RAGHAVAN M, KULSHRESHTHA S, et al. Transition-metal saccharide chemistry : synthesis, spectroscopy, electrochemistry and magnetic susceptibility studies of iron(I) complexes of mono-and disaccharides[J].Carbohydr Res, 1995, 271: 163
[63] FARKAS E, ENYEDY EA, ZÉKÁNY L, et al. Interaction between iron(Ⅰ) and hydroxamic acids: oxidation of iron
Biochem, 2001, 83(2-3): 107.
[64] SLAVOV L, ABRASHEV M, MERODIISKA T, et al. Raman spectroscopy investigation of magnetite nanoparticles in ferrofluids[J].J Magn Magn Mater, 2010, 322: 1904
[65] FULTZ B.Mossbauer spectrometry[M]//KAUFMANN EN. Characterization of Materials. 2nd Ed. New York: John Wiley & Sons, 2012
[66] OSHTRAKH MI, MILDER OB, SEMIONKIN VA.Determination of the iron state in ferrous iron containing vitamins and dietary supplements : application of Mossbauer spectroscopy[J].J Pharm Biomed Anal, 2006, 40(5): 1281
[67] 苏桂芬, 石德成.多糖对Fe00H微粒表面络合作用的穆斯堡尔谱研究[J].东北师大学报(自然科学), 1989(3): 85
SU GF, SHI DC.Mossbauer study of the interfacial complexing action of various polysaccharides with FeOOH cores[J].J Northeast Norm Univ(Nat Sci Ed), 1989(3): 85
