Quality Control

Combination of fingerprint and chemometrics for identification of four processed products of Pinelliae Rhizoma based on nucleosides and nucleobases

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  • 1. Suzhou Institute for Drug Control, Suzhou 215104, China;
    2. National Institutes for Food and Drug Control, Beijing 100050, China

Received date: 2020-08-08

  Online published: 2024-07-12

Abstract

Objective: To establish the common pattern of ten nucleosides and nucleobases,in order to identify four kinds of processed products of Pinelliae Rhizoma by fingerprint and chemometrics. Methods: The data in 18 batches of Pinelliae Rhizoma Praeparatum,40 batches of Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine,20 batches of Pinelliae Rhizoma Praeparatum cum Alumine and 10 batches of Pinelliae Rhizoma were collected by high performance liquid chromatography,and then the absolute peak areas were statistically analyzed. Common patterns were established for similarity analysis,principal component analysis( PCA),hierarchical cluster analysis and self-organizing feature mapping( SOM),so as to investigate the correction between components and sample classification. Results: Resultsindicated that samples of four kinds of processed products of Pinelliae Rhizoma were effectively classified by common pattern. Besides that,the most contribution components for classification were selected out for further quality control. Conclusion: In consideration of the complexity of traditional Chinese medicine,the analysis by fingerprint and chemometrics can collect majority components information from samples,which is benefit for species identification.

Cite this article

CHEN Wei, ZHANG Chao, SUN Lei, XUE Man . Combination of fingerprint and chemometrics for identification of four processed products of Pinelliae Rhizoma based on nucleosides and nucleobases[J]. Chinese Journal of Pharmaceutical Analysis, 2021 , 41(5) : 919 -928 . DOI: 10.16155/j.0254-1793.2021.05.22

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