Objective: To study the residual levels and enrichment characteristics of Cu,As,Cd,Hg and Pb in Coptidis Rhizoma from different localities,and to perform the risk evaluation by“ Guideline of Risk Assessment of Exogenous Harmful Residues in Traditional Chinese Medicines”. Methods: The contents of five heavy metals and harmful elements in Coptis samples and corresponding soil were determined by inductively coupled plasma mass spectrometry（ICP-MS）and the parameters of the instrument were as follows: radio frequency power: 1 400 W, auxiliary gas（argon） flow rate: 0.8 L· min-1,cooling gas flow rate: 13.0 L· min-1,plasma gas flow: 15.0 L· min-1, peristaltic pump: 20.0 r·min-1,sample depth: 15 mm,repeat times: 3 times,and scanning times: 100 times, detection method: automatic. SPSS 18.0,SIMCA 14.1 software and Excel 2010 were used to analyze the data. Results: Principal component analysis results showed that the differences between five heavy metals and harmful elements in the samples from the five areas were mainly reflected in the contents of As and Pb. The residual status of heavy metals and harmful elements in Coptidis Rhizoma was significantly different in different localities. The order of enrichment ability of Coptidis Rhizoma to five heavy metals and harmful elements was Cd,Cu,Hg,Pb,As, and the order of enrichment ability to Cd was fibrous root,rhizome,leaf or stem. According to the risk assessment requirements,the risk ratio of Pb was high in Coptidis Rhizoma. Conclusion: The enrichment characteristics of metal elements is closely related to the growth environment,harvest processing and other factors. It is necessary to select the areas with low metal elements in the growth environment to plant and standardize the harvest processing in order to obtain higher quality and safe traditional Chinese medicine.
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