[1] ADELS EA,MOHAMED AAO,ALAA AMAA,ed al.Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents:molecular docking study[J].Eur J Med Chem,2010,45(9):4188
[2] 贺宝灵,王美,郭瑞华.染料木素对 2 型糖尿病心肌病大鼠心肌细胞纤维化的影响[J].中国中医药科技,2015,22(1):33
HE BL,WANG M,GUO RH.Effects of genistein on myocardial fibrosis in type 2 diabetic cardiomyopathy rats[J].Chin Med Technol,2015,22(1):33
[3] 刘娜,周泉城.染料木素衍生物的合成及其生物活性研究[J]. 食品与药品,2016,18(4):235
LIU N,ZHOU QC.Synthesis and biological activity of genistein derivative[J].Food Drug,2016,18(4):235
[4] 陈敬荣,郑尧杰,尤付玲,等.染料木素通过 JNK 调控 Fas 通路的抗 Aβ 诱导的 PC12 细胞凋亡机制研究[J].中国药理学通报, 2015,31(2):175
CHEN JR,ZHENG YJ,YOU FL,et al.Genistein protects PC12 cells from Aβ(25-35)-induced apoptosis via JNK signaling and regulation of Fas pathway[J].Chin Pharmacol Bull,2015,31(2):175
[5] 罗芳贞. 染料木素衍生物体外抗氧化活性的筛选[D].衡阳:南华大学,2015
LUO FZ.In Vitro Antioxidant Activity Screening of Genistein Structure Modification[D].Hengyang:University of South China, 2015
[6] 胡炯,王伟东,王昌兴,等.染料木素调控 JAK2/STAT3 信号通路改善骨性关节炎大鼠软骨代谢的作用研究[J].中国临床药理学与治疗学,2018,23(4):383
HU J,WANG WD,WANG CX,et al.Effect of genistein on cartilage mediated by JAK2/STAT3 signaling pathway in rats with osteoarthritis[J].Chin Clin Pharmacol Therap,2018,23(4):383
[7] 汪婷婷,蔡标,王艳,等.染料木素对阿尔茨海默病模型大鼠氧化应激和 Bcl-2 的影响[J].中国临床药理学与治疗学,2016,21(12):1335
WANG TT,CAI B,WANG Y,et al,Effects of genistein on oxidative stress and Bcl-2 in rats with Alzheimer s disease[J].Chin Clin Pharmacol Therap,2016,21(12):1335
[8] PENG B,CAI JG,YI SS,et al.Inhibition of proliferation and induction of G1phase cell-cycle arrest by dFMGEN,a novel genistein derivative,in lung carcinoma A549 cells[J].Drug Chem Toxicol,2013,36(2):196
[9] LONG XK,LIAO LQ,ZENG YF,et al.Synthesis and Biological evaluation of novel genistein amino acid ester derivatives as potential anti-tumor agents[J].Med Chem Drug Disc,2019,4(19): 5662
[10] 龙小康. 染料木素衍生物合成、抗肿瘤活性及与牛血清白蛋白相互作用的研究[D].衡阳:南华大学,2019
LONG XK.Synthesis,Antitumor Activity And Interaction with Bovine Serum Albumin of Genistein Derivatives[D].Hengyang: University of South China,2019
[11] SHIMAZUT,INOUE M,SASAZUKI S,et al.Isoflavone in take and risk of lung cancer:a prospective cohort study in Japan[J].Am J Clin Nutr,2010,91:722
[12] YING XN,MENG X,XIAO CC,et al.Inactivation of AKT,ERK and NF-kB by genistein derivative,7-difluoromethoxyl-5,4’-di-n-octylygenistein,reduces ovarian carcinoma oncogenicity[J]. Oncol Reports,2017,38:949
[13] 杨庆晓,姚姝妍,宋彬,等.珠子参汤剂对脑胶质瘤 U87 细胞增殖、凋亡的影响及其机制研究[J].中国煤炭工业医学杂志, 2019,22(5):523
YANG QX,YAO SY,SONG B,et al .Effects of Zhuzishen decoction on proliferation and apoptosis of U87 glioma cells and its mechanisms[J].Chin J Coal Ind Med,2019,22(5):523
[14] PAOLA P,FRANCESCA L,FRANCESCA RA,et al.NOS2 inhibitor 1400W induces autophagic flux and inflfluences extracellular vesicle profifile in humanglioblastoma u87 cell line[J].Molecul Sci,2019, 20:3010
[15] 孙建军,李金娟,李长栋,等.UMSCs 对人神经胶质瘤 U87MG 细胞及其干细胞的凋亡诱导作用[J].西北国防医学杂志,2019, 40(3):139
SUN JJ,LI JJ,LI CD,et al.Apoptosis induction of umbilical cord mesenchymal stell cells in U87 malignant glioma mass cells and glioma stem cells[J],Northwest Nat Def Med J,2019,40(3):139
[16] JUE TR,SENA ES,MACLEOD MR,et al.A systematic review and meta-analysis of topoisomerase inhibition in preclinical glioma models[J].Oncotarget,2018,9(13):11387
[17] 张百平,孙树凯,贾栋.CBX8 过表达或沉默对人神经胶质瘤细胞增殖和凋亡的影响[J].中国病理生理杂志,2017,33(4): 723
ZHANG BP,SUN SK,JIA D.Effects of silencing and overexpression of CBX8 on proliferation and apoptosis of human glioma cells[J]. Chin J Pathophysiol,2017,33(4):723
[18] LYNCH TJ,BELL DW,SORDELLA R,et al.Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib[J].New England J Med, 2004,350(21):2129
[19] KRIS MG,NATALE RB,HERBST RS,et al.Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase,in symptomatic patients with non-small cell lung cancer:a randomized trial[J].JAMA,2003,290(16):2149
[20] BATO L,GRO B,LIEN MD,et al.Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy:a randomized,placebo-controlled,double-blind phase 2 clinical trial[J].Nutr Cancer,2011,63(6):889
[21] KUMAR NB,CANTOR A,ALLEN K,et al.The specific role of isoflavones in reducing prostate cancer risk[J].Prostate,2004, 59:141
[22] CHANG KL,CHENG HL,HUANG LW,et al.Combined effects of terazosin and genistein on a metastatic,hormone-independent human prostate cancer cell line[J].Cancer Lett,2009,276(1):14
[23] SEYEDSABER M,DANIEL EAK,YADOLLAH S,et al.Efects of temozolomide on U87MG glioblastoma cell expression of CXCR4, MMP2,MMP9,VEGF,anti-proliferatory cytotoxic and apoptotic properties[J].Molecular Biol Reports,2020,47(2):1187
[24] ZHANG P,HU L,YIN Q,et al.Transferr in modified cpaclitaxel loaded hybrid micelle for sequential bloodbrain barrier penetration and glioma targeting therapy[J].Mol Pharm,2012,9(6):1590
[25] 孙军凤,周泉城.染料木素抗肿瘤衍生物的研究进展[J].中国食品卫生杂志,2014,26(3):303
SUN JF,ZHOU QC.Progress on genistein antitumor derivatives[J]. Chin J Food Hyg,2014,26(3):303
