Objective: In order to explore the residual characteristics of heavy metals and harmful elements in different kinds of herbs,the contamination situation was analyzed by N.L.Nemerow comprehensive contamination index method, and the basis for the formulation of safety limit standard was provided. Methods: Microwave digestion-ICP-MS was used to determine the heavy metals and harmful elements residues in 2 427 batches of 37 kinds of Chinese herbal medicines,including flowers,leaves,whole herbs,fruits and seeds. Results: The recovery rates were 62.7%- 121.1%,and RSDs were 0.2%-13.0%,indicating that the method was accurate and reliable. The total qualified rate of the samples was 71.4%. And the unqualified rates of heavy metals were as follows:cadmium（20.9%）>lead （5.8%）>copper（3.9%）>mercury（3.5%）>arsenic（2.9%）. The qualified rates of different parts were as follows: seeds（97.3%）,fruits（92.0%）,flowers（68.5%）,whole herbs（53.2%）,and leaves（51.3%）. Conclusion: Leaves and whole herbs were easy to accumulate heavy metals and harmful elements,followed by flowers. Residues situation in fruits and seeds were good. Flowers and whole herbs were the most likely to accumulate cadmium. Lonicerae Flos,Hedyotis Diffusa,Andrographis Herba,Artemisiae Argyi Folium,Artemisiae Annuae Herba, Houttuyniae Herba,Artemisiae Scopariae Herba and Desmodii Styracifolii Herba were seriously contaminated by heavy metals and harmful elements. Cadmium in Lonicerae Flos and Hedyotis Diffusa,arsenic in Artemisiae Scopariae Herba,and lead in Hedyotis Diffusa,Andrographis Herba,Artemisiae Argyi Folium,Artemisiae Annuae Herba,Houttuyniae Herba,Artemisiae Scopariae Herba,Desmodii Styracifolii Herba were at risk of contamination.
FEI Yi-qin, XIAO Ling, WANG Bo, ZHU Hai-lan, NIE Jing
. Residue analysis and risk assessment of heavy metals and harmful elements in 37 plant medicinal materials*[J]. Chinese Journal of Pharmaceutical Analysis, 2021
, 41(6)
: 1000
-1008
.
DOI: 10.16155/j.0254-1793.2021.06.09
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