分析方法性能持续确认是确保方法在完成验证后持续满足其预期用途的过程。本文在前期研究的基础上,进一步探讨方法性能持续确认的指标(包括系统适用性指标和报告值等)和实施分析工具(控制图),并以示例演示方法性能持续确认的具体操作步骤。希望本文可以为药品领域,特别是企业和监管部门在方法确认的科学化、规范化方面提供新的思路。
Ongoing procedure performance verification (OPPV) of an analytical procedure is the process of ensuring it continues to meet its intended use after completion of validation. On the basis of previous studies, this paper further discussed the indicators of ongoing procedure performance verification (including system suitability indicators and reported values, etc.) and the implementation of analysis tools (control charts), and demonstrated the specific operation steps of ongoing procedure performance verification with examples. It is hoped that this paper will provide new ideas for the accurate and standardized procedure verification in the pharmaceutical field, especially in the enterprises and regulatory departments.
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