综述专论

静电纺丝技术在违禁药物固相萃取领域的研究进展*

展开
  • 1.中国人民公安大学侦查学院,北京 100038;
    2.国家毒品实验室北京分中心,北京 100164;
    3.天津市公安局物证鉴定中心,天津 300380
第一作者 Tel:18810153657;E-mail:niukexin_0212@163.com
**廉 洁 Tel:17310411051;E-mail:rlianjie@163.com
赵 霞 Tel:13681526636;E-mail:lubin_fast@sohu.com

修回日期: 2024-02-26

  网络出版日期: 2024-06-20

基金资助

*双一流建设科研项目:中国人民公安大学刑事科学技术双一流创新研究专项(2023SYL06)

Research of illicit drugs extraction technology based on electrospinning*

Expand
  • 1. School of Investigation, People’s Public Security University of China, Beijing 100038, China;
    2. National Anti-Drug Laboratory Beijing Regional Center, Beijing 100164, China;
    3. Institute of Forensic Science, Tianjin Municipal Public Security Bureau, Tianjin 300380, China

Revised date: 2024-02-26

  Online published: 2024-06-20

摘要

违禁药物以微量、痕量甚至超痕量的水平,广泛分布于生物、食品、环境和药物等复杂基质,可能会造成急性中毒、慢性中毒、毒品滥用等问题,违禁药物分析是公共安全领域一直以来的关注焦点。固相萃取是分析复杂基质中违禁药物常用的前处理技术,但萃取痕量级别违禁药物时,易出现样品利用率低、萃取灵敏度差等问题,难以满足公共安全领域灵敏快速的分析需求。为此,具有强大尺寸优势的纳米纤维、纳米颗粒等材料,用于固相萃取技术的开发和创新。静电纺丝技术是连续、大量生产纳米纤维最常用的方法,具有工艺简单、材料多样、纤维尺寸可控等优势,现已广泛用于分析萃取领域。静电纺丝技术经历了从采用单一聚合物纺丝,到多种聚合物混纺、添加功能材料的纳米颗粒修饰等发展,制备的静电纺丝纳米纤维机械性、选择性和稳定性均逐渐提升,拓宽了该技术在违禁药物分析中的适用范围。目前,静电纺丝技术在违禁药物固相萃取中的应用仍属起步阶段,本文系统地综述了静电纺丝在传统固相萃取、微型化固相萃取和分散固相萃取中的研究现状,并对未来可能的发展方向提供了建议,以期为相关问题的深入研究提供参考。

本文引用格式

牛可歆, 廉洁, 赵霞, 宋树强, 苏雪, 肖楠 . 静电纺丝技术在违禁药物固相萃取领域的研究进展*[J]. 药物分析杂志, 2024 , 44(4) : 553 -561 . DOI: 10.16155/j.0254-1793.2024.04.01

Abstract

Illicit drugs are widely distributed in complex substrates such as biology, food, environment and drugs at minor, trace and even ultra-trace levels, which may cause acute poisoning, chronic poisoning, drug abuse and other problems. The analysis of illicit drugs has always been the focus of public safety. Solid phase extraction is a commonly used pretreatment technology for the analysis of illicit drugs in complex substrates. However, when extracting trace level illicit drugs, problems such as low sample utilization rate and poor extraction sensitivity may occur, which are difficult to meet the needs of sensitive and rapid analysis in the field of public safety. To this end, nanofibers, nanoparticles and other materials with strong size advantages are used for optimization and innovation of solid phase extraction technology. Electrospinning technology is the most commonly used method for continuous and mass production of nanofibers. It has the advantages of simple process, diverse materials and controllable fiber size, and has been widely used in the field of analysis and extraction. The electrospinning technology has experienced the development from spinning with a single polymer to blending with a variety of polymers and modifying nanoparticles with functional materials. The mechanical properties, selectivity and stability of the electrospinning nanofibers prepared have also been gradually improved, broadening the application scope of this technology in the analysis of illicit drugs. At present, the application of electrospinning technology in solid phase extraction of illicit drugs is still in its infancy. This paper systematically reviews the research status of electrospinning in traditional solid phase extraction, micro-solid phase extraction and dispersed solid phase extraction, and provides suggestions for its possible future development, in order to provide reference for further research on related issues.

参考文献

[1] 张敏, 黄京平, 赵文, 等. 超高效液相色谱-串联质谱法测定蜂蜜中24种酚酸和黄酮类化合物[J]. 分析测试学报, 2022, 41(11):1636
ZHANG M, HUANG JP, ZHAO W, et al. Determination of 24 kinds of phenolic acids and flavonoids in honey by ultra-high performance liquid chromatography-tandem mass spectrometry[J]. J Instrum Anal, 2022, 41(11):1636
[2] PETRIE B, BARDEN R, KASPRZYK-HORDERN B. A review on emerging contaminants in wastewaters and the environment: current knowledge, understudied areas and recommendations for future monitoring[J]. Water Res, 2015, 72: 3
[3] 韩旭, 苏雪, 周进. 口服普萘洛尔中毒致死检验1例[J]. 中国法医学杂志, 2021, 36(4):434
HAN X, SU X, ZHOU J. A case of oral propranolol poisoning death[J]. Chin J Forensic Med, 2021, 36(4):434
[4] 王群, 宋树强, 马华. 气质联用SIM技术在毒物检测中的应用[J]. 刑事技术, 2004, 29(2):22
WANG Q, SONG SQ, MA H. Application of GC/MS-SIM in poison analysis[J]. Forensic Sci Technol, 2004, 29(2):22
[5] 赵霞, 梁武斌, 曾立波, 等. SELEX体外筛选溴敌隆DNA适配体研究[J]. 中国司法鉴定, 2020(4):45
ZHAO X, LIANG WB, ZENG LB, et al. In vitro selection of bromadiolone DNA aptamers by SELEX[J]. Chin J Forensic Sci, 2020(4):45
[6] 王雪, 杨玉婷, 赵立春, 等. 基于UPLC-MS/MS技术测定大鼠血浆中的氨甲环酸[J]. 化学研究, 2022, 33(3):236
WANG X, YANG YT, ZHAO LC, et al. Determination of tranexamic acid in rat plasma by UPLC-MS/MS technique[J]. Chem Res, 2022, 33(3):236
[7] 赵永斌, 肖楠. 全自动固相萃取-气质联用法检验水样中扑草净[J]. 中国刑警学院学报, 2020(5):99
ZHAO YB, XIAO N. Automatic solid-phase extraction-temperament-combined method for the determination of prochlorin in water samples[J]. J Crim Invest Police Univ China, 2020 (5):99
[8] 邸玉敏, 肖楠, 王瑞花, 等. 血液中7种新型合成大麻素的方法学研究[J]. 中国法医学杂志, 2022, 37(6):575
DI YM, XIAO N, WANG RH, et al. Determination of synthetic cannabinoids in blood by QTRAP LC-MS/MS [J]. Chin J Forensic Med, 2022, 37(6):575
[9] ANZILLOTTI L, MAREZZA F, CALO L, et al. Determination of synthetic and natural cannabinoids in oral fluid by solid-phase microextraction coupled to gas chromatography/mass spectrometry: a pilot study[J]. Talanta, 2019, 201: 335
[10] CHEN X, WU X, LUAN T, et al. Sample preparation and instrumental methods for illicit drugs in environmental and biological samples: a review[J]. J Chromatogr A, 2021, 1640: 461961
[11] LI C, ZHU H, LI C, et al. The present situation of pesticide residues in China and their removal and transformation during food processing[J]. Food Chem, 2021, 354: 129552
[12] 孙晓玮, 王晓, 纪文华. 共价有机骨架材料在分离科学中的研究进展[J]. 分析测试学报, 2020, 39(7):935
SUN XW, WANG X, JI WH. Progress of covalent organic frameworks in separation science [J]. J Instrum Anal, 2020, 39(7):935
[13] AGARWAL S, WENDORFF JH, GREINER A. Use of electrospinning technique for biomedical applications[J]. Polymer, 2008, 49(26):5603
[14] HUANG ZM, ZHANG YZ, KOTAKI M, et al. A review on polymer nanofibers by electrospinning and their applications in nanocomposites[J]. Compos Sci Technol, 2003, 63(15):2223
[15] RAMAKRISHNA S, FUJIHARA K, TEO WE, et al. Electrospun nanofibers: solving global issues[J]. Mater Today, 2006, 9(3):40
[16] SILL TJ, VON RECUM HA. Electro spinning: applications in drug delivery and tissue engineering[J]. Biomaterials, 2008, 29(13):1989
[17] XUE J, WU T, DAI Y, et al. Electrospinning and electrospun nanofibers: methods, materials, and applications[J]. Chem Rev, 2019, 119(8):5298
[18] TAN S, HUANG X, WU B. Some fascinating phenomena in electrospinning processes and applications of electrospun nanofibers[J]. Polym Int, 2007, 56(11):1330
[19] BHARDWAJ N, KUNDU SC. Electrospinning: a fascinating fiber fabrication technique[J]. Biotechnol Adv, 2010, 28(3):325
[20] GUO Y, WANG X, SHEN Y, et al. Research progress, models and simulation of electrospinning technology: a review[J]. J Mater Sci, 2022, 57(1):58
[21] QIU Q, WU Y, YAN X, et al. Porous electrospun microfibers for low flow-resistant solid phase extraction of fluoroquinolones in tap water, egg and milk samples[J]. J Chromatogr A, 2022, 1661: 462719
[22] ERBIN J, KLICOVA M, KLAPS TOVA A, et al. New polyamide 6 nanofibrous sorbents produced via alternating current electrospinning for the on-line solid phase extraction of small molecules in chromatography systems[J]. Microchem J, 2022, 174(1):107084
[23] CHEN A, GUO H, LUAN J, et al. The electrospun polyacrylonitrile/covalent organic framework nanofibers for efficient enrichment of trace sulfonamides residues in food samples[J]. J Chromatogr A, 2022, 1668: 462917
[24] KANG X, PAN C, XU Q, et al. The investigation of electrospun polymer nanofibers as a solid-phase extraction sorbent for the determination of trazodone in human plasma[J]. Anal Chim Acta, 2007, 587(1):75
[25] 王燕, 陈利琴, 许茜, 等. 电纺纳米纤维固相微萃取犬血浆中维拉帕米[J]. 中国药理学通报, 2007, 6(1):832
WANG Y, CHEN LQ, XU Q, et al. Electrospun polymer nanofibers packed micro-column for the solid-phase extraction of verapamil in dog plasma [J]. Chin Pharmacol Bull, 2007, 23(6):832
[26] KANG XJ, CHEN LQ, WANG Y, et al. Design of packed-fiber solid-phase extraction device for analysis of the drug and its metabolite in plasma[J]. Biomed Microdevices, 2009, 11(4):723
[27] SUN J, WANG Y, ZHOU XL, et al. The investigation of electrospun polymer nanofibers as a solid-phase extraction sorbent for the determination of benzimidazoles in pork[C]//International Conference on Nanotechnology and Precision Engineering. Guilin: Trans Tech Publicatons Ltd., 2013: 239
[28] CHEN R, YANG Y, WANG N, et al. Application of packed porous nanofibers-solid-phase extraction for the detection of sulfonamide residues from environmental water samples by ultra high performance liquid chromatography with mass spectrometry[J]. J Sep Sci, 2015, 38(5):749
[29] BAGHERI H, ASGARI S, PIRI-MOGHADAM H. On-line micro solid-phase extraction of clodinafop propargyl from water, soil and wheat samples using electrospun polyamide nanofibers[J]. Chromatographia, 2014, 77(9-10):723
[30] AQADA TG, BEHKAMI S, BAGHERI H. Porous eco-friendly fibers for on-line micro solid-phase extraction of nonsteroidal anti-inflammatory drugs from urine and plasma samples[J]. J Chromatogr A, 2018, 1574: 18
[31] AMINI S, EBRAHIMZADEH H, SEIDI S, et al. Preparation of polyacrylonitrile/Ni-MOF electrospun nanofiber as an efficient fiber coating material for headspace solid-phase microextraction of diazinon and chlorpyrifos followed by CD-IMS analysis[J]. Food Chem, 2021, 350: 129242
[32] ARABSORKHI B, SERESHTI H, ABBASI A. Oxygen flux as an indicator of physiological stress in aquatic organisms: a real-time biomonitoring system of water quality[J]. J Sep Sci, 2019, 42(8):1500
[33] ASIABI M, MEHDINIA A, JABBARI A. Electrospun metal-organic framework/polyacrylonitrile composite nanofibrous mat as a microsorbent for the extraction of tetracycline residue in human blood plasma[J]. J Chromatogr A, 2015, 1426(1):24
[34] AMINI S, EBRAHIMZADEH H, SEIDI S, et al. Preparation of electrospun polyacrylonitrile/Ni-MOF-74 nanofibers for extraction of atenolol and captopril prior to HPLC-DAD[J]. Microchim Acta, 2020, 187(9):508
[35] KHEZELI T, DANESHFAR A. Development of dispersive micro-solid phase extraction based on micro and nano sorbents[J]. Trends Analyt Chem, 2017, 89(1):99
[36] WEI L, CHEN Y, SHAO D, et al. Simultaneous determination of nine quinolones in pure milk using PFSPE-HPLC-MS/MS withPS-PAN nanofibers as a sorbent[J]. Foods, 2022, 11(13):1843
[37] CHEN LQ, WANG Y, QU JS, et al. Selective extraction of catecholamines by packed fiber solid-phase using composite nanofibers composing of polymeric crown ether with polystyrene[J]. Biomed Chromatogr, 2015, 29(1):103
[38] CHU L, ZHENG S, QU B, et al. Detection of beta-agonists in pork tissue with novel electrospun nanofibers-based solid-phase extraction followed ultra-high performance liquid chromatography/tandem mass spectrometry[J]. Food Chem, 2017, 227: 315
[39] SOBOLCIAK P, TANVIR A, POPELKA A, et al. The preparation, properties and applications of electrospun co-polyamide 6,12 membranes modified by cellulose nanocrystals[J]. Mater Des, 2017, 132: 314
[40] REYES-GALLARDO EM, LUCENA R, CARDENAS S. Electrospun nanofibers as sorptive phases in microextraction[J]. Trends Analyt Chem, 2016, 84: 3
[41] BAGHERI H, AYAZI Z, AGHAKHANI A, et al. Polypyrrole/polyamide electrospun-based sorbent for microextraction in packed syringe of organophosphorous pesticides from aquatic samples[J]. J Sep Sci, 2012, 35(1):114
[42] SEIDI S, DOROUDIAN M. Electrospun NiFe layered double hydroxide/Nylon 6 composite nanofibers as a sorbent for micro solid phase extraction by packed sorbent of non-steroidal anti-inflammatory drugs in human blood[J]. J Chromatogr A, 2020, 1614: 460718
[43] ZHANG X, LIANG Q, HAN Q, et al. Metal-organic frameworks@graphene hybrid aerogels for solid-phase extraction of nonsteroidal anti-inflammatory drugs and selective enrichment of proteins[J]. Analyst, 2016, 141(13):4219
[44] WANG R, LI C, LI Q, et al. Electrospinning fabrication of covalent organic framework composite nanofibers for pipette tip solid phase extraction of tetracycline antibiotics in grass carp and duck[J]. J Chromatogr A, 2020, 1622: 461098
[45] YAN Z, WU M, HU B, et al. Electrospun UiO-66/polyacrylonitrile nanofibers as efficient sorbent for pipette tip solid phase extraction of phytohormones in vegetable samples[J]. J Chromatogr A, 2018, 1542: 19
[46] AMINI S, EBRAHIMZADEH H, SEIDI S, et al. Polyacrylonitrile/MIL-53(Fe) electrospun nanofiber for pipette-tip micro solid phase extraction of nitrazepam and oxazepam followed by HPLC analysis[J]. Microchim Acta, 2020, 187(2):152
[47] KANDEH SH, AMINI S, EBRAHIMZADEH H. PVA/Stevia/MIL-88A@AuNPs composite nanofibers as a novel sorbent for simultaneous extraction of eight agricultural pesticides in food and vegetable samples followed by HPLC-UV analysis[J]. Food Chem, 2022, 386: 132734
[48] HEJABRI KS, AMINI S, EBRAHIMZADEH H. Simultaneous trace-level monitoring of seven opioid analgesic drugs in biological samples by pipette-tip micro solid phase extraction based on PVA-PAA/CNT-CNC composite nanofibers followed by HPLC-UV analysis[J]. Microchim Acta, 2021, 188(8):275
[49] KHODAYARI P, JALILIAN N, EBRAHIMZADEH H, et al. Electrospun cellulose acetate/polyacrylonitrile/thymol/Mg-metal organic framework nanofibers as efficient sorbent for pipette-tip micro-solid phase extraction of anti-cancer drugs[J]. React Funct Polym, 2022, 173: 105217
[50] TIAN R, ZHANG H, YE M, et al. Selective extraction of peptides from human plasma by highly ordered mesoporous silica particles for peptidome analysis[J]. Angew Chem Int Ed Engl, 2007, 46(6):962
[51] 郭丽囡, 王雅慧, 闫萌, 等. 基于掺杂金属有机骨架CeDUT-52分散固相萃取/高效液相色谱法检测水中的双酚类化合物[J]. 分析测试学报, 2022, 41(2):164
GUO LN, WANG YH, YAN M, et al. Detection of bisphenols compounds in water by high performance liquid chromatography with dispersive solid phase extraction based on Ce-Doped DUT-52 metal organic framework[J]. J Instrum Anal, 2022, 41(2):164
[52] 杨霄, 万译文, 黄华伟, 等. 分散固相萃取-超高效液相色谱-串联质谱法测定水产品中5种硝基咪唑类和6种苯二氮类药物[J]. 色谱, 2022, 40(7):625
YANG X, WAN YW, HUANG HW, et al Determination of five nitroimidazoles and six benzodiazepines in aquatic products using ultra-high performance liquid chromatography-tandem mass spectrometry coupled with dispersive solid-phase extraction[J]. Chin J Chromatogr, 2022, 40(7):625
[53] HE XM, ZHU GT, ZHENG HB, et al. Facile synthesis of polyaniline-coated SiO2 nanofiber and its application in enrichment of fluoroquinolones from honey samples[J]. Talanta, 2015, 140: 29
[54] 冯娟娟, 孙明霞, 冯洋, 等. 石墨烯应用于样品前处理的研究进展[J]. 色谱, 2022, 40(11):953
FENG JJ, SUN MX, FENG Y, et al. Recent advances in the use of graphene for sample preparation [J]. Chin J Chromatogr, 2022, 40(11):953
[55] ARABSORKHI B, SERESHTI H. Determination of tetracycline and cefotaxime residues in honey by micro-solid phase extraction based on electrospun nanofibers coupled with HPLC[J]. Microchem J, 2018, 140(1):241
[56] KARIMIYAN H, UHEIDA A, HADJMOHAMMADI M, et al. Polyacrylonitrile/graphene oxide nanofibers for packed sorbent microextraction of drugs and their metabolites from human plasma samples[J]. Talanta, 2019, 201: 474
[57] WENG R, SUN L, JIANG L, et al. Electrospun graphene oxide-doped nanofiber-based solid phase extraction followed by high-performance liquid chromatography for the determination of tetracycline antibiotic residues in food samples[J]. Food Anal Methods, 2019, 12(7):1594
[58] YAN X, ZHAN Y, ZHONG D, et al. Electrospun nanofiber cloud for ultrafast solid phase micro-extraction of trace organics in water samples[J]. J Chromatogr A, 2018, 1574: 42
[59] FEIZBAKIISH A, EHTESHAMI S. Modified magnetic nanoparticles as a novel sorbent for dispersive magnetic solid-phase extraction of triazine herbicides in aqueous media[J]. J AOAC Int, 2017, 100(1):198
[60] PIRDADEH-BEIRANVAND M, AFKHAMI A, MADRAKIAN T. Magnetic molecularly imprinted electrospun nanofibers for selective extraction of nilotinib from human serum[J]. Anal Bioanal Chem, 2020, 412(7):1629
文章导航

/