综述专论

忍冬中的活性成分及其药理活性研究现状*

展开
  • 陕西理工大学 化学与环境科学学院,汉中 723000
第一作者 Tel:17720787859;E-mail:hmc921710973@163.com
** Tel:13892631822;E-mail:tiangh@snut.edu.cn

收稿日期: 2023-04-19

  网络出版日期: 2024-06-21

基金资助

* 陕西省科技厅社会发展科技攻关项目(2022SF-356);陕西省教育厅科研项目(21JK0565和21JS004)

Research prospect on active constituent and pharmacological activity of flavonoids from Lonicera japonica*

Expand
  • School of Chemical and Environment Science, Shaanxi Univercity of Technology, Hanzhong 723000, China

Received date: 2023-04-19

  Online published: 2024-06-21

摘要

忍冬是一种药用历史悠久的药食同源的植物,分布广泛,药理活性显著。忍冬中含有丰富的酚酸类、黄酮类、环烯醚萜类、三萜皂苷类、挥发油等活性成分,具有抗氧化、抑菌、抗病毒等多种药理活性,通过查阅知网、万方、X-mol等多个文献数据库,着重引证近五年的主要文献,将金银花、藤、叶中的主要活性成分以及忍冬提取物的药理活性进行总结概述,为忍冬的综合开发利用及其深加工应用提供参考。

本文引用格式

郝梦超, 姚甜, 刘二奴, 吴睿, 刘存芳, 田光辉 . 忍冬中的活性成分及其药理活性研究现状*[J]. 药物分析杂志, 2024 , 44(2) : 195 -213 . DOI: 10.16155/j.0254-1793.2024.02.02

Abstract

Lonicera japonica is a kind of medicinal plant with a long history of medicinal and edible homology, which is widely distributed and has significant pharmacological activity. L. japonica contains abundant phenolic acids, flavonoids, iridoid, triterpenoid saponins, volatile oils and other active ingredients, which have antioxidant, antibacterial, antiviral and other pharmacological activities. Through consulting multiple literature databases such as Jihn.com, Wanfang and X-mol, the main literature in the past five years was mainly cited. The main active components in L. japonica, rattan and leaves and the pharmacological activities of L. japonica extract were summarized, which provided reference for the comprehensive exploitation and deep processing of L. japonica.

参考文献

[1] 高新生, 张又莉, 韩立虎. 金银花口服液治疗普通型新型冠状病毒肺炎1例临床观察[J]. 中国药业, 2020, 29(7): 58
GAO XS, ZHANG YL, HAN LH. Clinical observation of honeysuckle oral liquid in treatment of common type novel coronavirus pneumonia: a case report [J]. China Pharm, 2020, 29(7): 58
[2] 吕端阳, 秦显达, 陈斌. 单味忍冬叶治疗急性腹泻21例[J]. 辽宁中医杂志,2003, 59(4): 298
LÜ DY, QIN XD, CHEN B. Single folium lonicerae treatment of acute diarrhea 21 cases [J]. J Liaoning Tradit Chin Med, 2003, 59(4): 298
[3] 中华人民共和国药典2020年版.一部 [S]. 2020: 230
ChP 2020.Vol Ⅰ[S]. 2020: 230
[4] 贾献慧, 李静, 张永清. 忍冬藤化学成分研究进展[J]. 山东中医杂志, 2015, 34(8): 641
JIA XH, LI J, ZHANG YQ. Honeysuckle stem chemical research progress [J]. J Shandong Tradit Chin Med, 2015, 34(8): 641
[5] 龚兴成, 刘文静, 曹丽波, 等. DI-MS/MS~(ALL)法快速定性分析金银花的化学成分[J]. 中国中药杂志, 2021, 46(9): 2220
GONG XG, LIU WJ, CAO LB, et al. Rapid qualitative analysis of chemical constituents of Flos Lonicerae by DI-MS/MS~(ALL) method [J]. China J Chin Mater Med, 2021, 46(9): 2220
[6] 马云, 王尧尧, 王蕾, 等.忍冬花发育期间形态与13种活性成分含量变化[J]. 中药材, 2018, 41(7): 1559
MA Y, WANG YY, WANG L, et al. Changes of flower morphology and contents of 13 active components in honeysuckle during flower development [J]. J Chin Med Mater, 2018, 41(7):1559
[7] 王玲娜, 孙希芳, 张芳, 等. 不同发育时期金银花颜色与活性成分的相关性分析[J]. 中草药, 2017, 48(15): 3182
WANG LN, SUN XF, ZHNAG F, et al. Analysis on the correlation between color and active components of Flos Lonicera at different developmental stages [J]. Chin Tradit Herb Drugs, 2017, 48(15): 3182
[8] LI RJ, KUANG XP, WANG WJ, et al. Comparison of chemical constitution and bioactivity among different parts of Lonicera japonica Thunb [J]. J Sci Food Agric, 2020, 100(2): 614
[9] 孙玉, 郭中原, 陈两绵, 等. 基于分子对接技术筛选金银花抗新型冠状病毒活性成分研究[J]. 世界中医药, 2021, 16(17): 2520
SUN Y, GUO ZY, CHEN LM, et al. Screening of anti-novel coronavirus active components of Flos Lonicerae based on molecular docking technology [J]. World Chin Med, 2021, 16(17): 2520
[10] 林鹏飞, 贾小舟, 祁燕, 等. 酚酸类化合物研究进展[J]. 广东化工, 2017, 44(1): 50
LIN PF, JIA XZ, QI Y, et al. Research progress of phenolic acids [J]. Guangdong Chem Ind, 2017, 44(1): 50
[11] 李会军, 李萍. 忍冬花蕾的化学成分研究[J]. 林产化学与工业, 2005, 64(3): 29
LI HJ, LI P. Study on chemical constituents of honeysuckle flower buds [J]. Chem Ind For Prod, 2005, 64 (3): 29
[12] 何敏. 金银花对细菌生物膜的抑制作用及其化学成分研究[D]. 长春:长春中医药大学, 2011
HE M. Study on the Inhibitory Effect and Chemical Constituents of Honeysuckle on Bacterial Biofilm [D]. Changchun:Changchun University of Traditional Chinese Medicine, 2011
[13] LEE EJ, KIM JS, KIM HP, et al. Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities [J]. Food Chem, 2010, 120(1): 134
[14] PENG LY, MEI SX, JIANG B, et al. Constituents from Lonicera japonica [J]. Fitoterapia, 2000, 71(6): 713
[15] WAN HQ, GE LL, XIAO LY, et al. 3,4,5-tri-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. Flower buds facilitates hepatitis B virus replication in HepG2.2.15 cells [J]. Food Chem Toxicol, 2020, 138(prepublish): 111250
[16] 姚静远, 单宇, 鲁正熹, 等. 灰毡毛忍冬花蕾乙醇提取物中酚酸类化学成分[J]. 植物资源与环境学报, 2023, 32(1): 92
YAO JY, SHAN Y, LU ZX, et al. Phenolic acids in ethanol extract of Lonicera cinerea flower bud[J]. J Plant Resour Environ, 2023, 32(1): 92
[17] 国晓莹, 王雨伟, 于晓, 等. HPLC-DAD同时测定忍冬不同发育期花和叶片中11种活性成分含量[J]. 中国中药杂志, 2022, 47(8): 2148
GUO XY, WANG YW, YU X, et al. Simultaneous determination of 11 active components in flowers and leaves of honeysuckle at different development stages by HPLC-DAD [J]. China J Chin Mater Med, 2022, 47(8): 2148
[18] 郑重飞. 金银花和鸡桑的化学成分与生物活性研究[D]. 北京:北京协和医学院, 2010
ZHENG CF. Study on the Chemical Constituents and Biological Activities of Honeysuckle and Cocksberry [D]. Beijing:Peking Union Medicine College, 2010
[19] 熊乐文, 张龙霏, 李佳, 等. 金银花酚酸类成分的提取优化及其成分分布[J]. 中药材, 2022, 45 (8): 1939
XIONG LW, ZHANG LF, LI J, et al. Extraction and optimization of honeysuckle phenolic acids and their distribution [J]. J Chin Med Mater, 2022, 45(8): 1939
[20] DUAN XY, FENG F, CHEN FM, et al. Multi-marker scans coupled to high-resolution mass spectrometry strategy for global profiling combined with structure recognition of unknown trace chlorogenic acids in Lonicera Flos [J]. Talanta, 2021, 226(15): 122134
[21] 张家燕. 中药金银花的药用成分及药理作用分析[J]. 中国医药指南, 2019, 17(17): 177
ZHANG JY, Analysis of medicinal ingredients and pharmacological effects of Flos Lonicera [J]. Chin Med Guide, 2019, 17(17): 177
[22] 王凯, 刘双, 李蒙, 等. 忍冬叶化学成分及其保肝活性研究[J]. 中草药, 2022, 53(8): 2285
WANG K, LIU S, LI M, et al. Study on chemical constituents and hepatoprotective activity of honeysuckle leaves [J]. Chin Tradit Herb Drugs, 2022, 53(8): 2285
[23] 马俊利, 李宁, 李铣. 忍冬叶中咖啡酰奎宁酸类化学成分[J]. 中国中药杂志, 2009, 34(18): 2346
MA JL, LI N, LI X. Chemical constituents of caffeoyl quinic acids in Honeysuckle leaves [J]. China J Chin Mater Med, 2009, 34(18):2346
[24] 刘婵娟, 陈四平. 忍冬叶的化学成分[J]. 中国实验方剂学杂志, 2010, 16(17): 90
LIU CJ, CHEN SP. The chemical composition of folium lonicerae [J]. Chin J Exp Tradit Med Form, 2010, 16(17): 90
[25] WANG DJ, DU N, WEN L, et al. An efficient method for the preparative isolation and purification of flavonoid glycosides and caffeoylquinic acid derivatives from leaves of Lonicera japonica Thunb. Using high speed counter-current chromatography (HSCCC) and Prep-HPLC guided by DPPH-HPLC experiments [J]. Molecules, 2017, 22(2): 229
[26] 田伟, 范帅帅, 甄亚钦, 等. UPLC比较金银花、忍冬藤和忍冬叶中11种活性成分的含量[J]. 中国中药杂志, 2019, 44(1): 100
TIAN W, FAN SS, ZHEN YQ, et al. UPLC compared the contents of 11 active ingredients in honeysuckle, honeysuckle and honeysuckle leaves [J]. China J Chin Mater Med, 2019, 44(1): 100
[27] 张聪, 殷志琦, 叶文才, 等. 忍冬藤的化学成分研究[J]. 中国中药杂志, 2009, 34(23): 3051.
ZHANG C, YIN ZQ, YE WC, et al. Study on chemical constituents of Honeysuckle Vine [J]. China J Chin Mater Med, 2009, 34(23): 3051
[28] 马荣, 殷志琦, 张聪, 等. 忍冬藤正丁醇萃取部位的化学成分[J]. 中国药科大学学报, 2010, 41(4): 333
MA R, YIN ZQ, ZHANG C, et al. Chemical constituents of n-butanol extract from Lonicera japonica [J]. J China Pharm Univ, 2010, 41(4): 333
[29] 黄文静, 熊乐文, 张龙霏, 等. 不同种质金银花发育过程中黄酮类成分含量变化规律研究[J]. 中草药, 2022, 53(10): 3156
HUANG WJ, XIONG LW, ZHANG LF, et al. Study on the variation of flavonoids content in different germplasm honeysuckle during its development [J]. Chin Tradit Herb Drugs, 2022, 53(10): 3156
[30] KUJAWA DB, PRUCHNIK H, CYBORAN S, et al. Biophysical mechanism of the protective effect of blue honey-suckle (Lonicera caerulea L.var.kamtschatica Sevast.) polyphe-nols extracts against lipid peroxidation of erythrocyte and lipid membranes [J]. J Memb Biol, 2014, 247(7): 611
[31] HAN MH, LEE WS, NAGAPPAN A, et al. Flavonoids isolated from flowers of Lonicera japonica Thunb. inhibit inflammatory responses in BV2 microglial cells by suppressing TNF-alpha and IL-beta through PI3K/Akt/NF-kb signaling pathways [J]. Phytother Res, 2016, 30(11): 1824
[32] 邢俊波, 李会军, 李萍, 等. 忍冬花蕾化学成分研究[J]. 中国新药杂志, 2002, 33(11): 856
XING JB, LI HJ, LI P, et al. Study on chemical constituents of honeysuckle flower bud [J]. Chin J New Drugs, 2002, 33(11): 856
[33] 冯卫生, 陈欣, 郑晓珂, 等. 金银花化学成分研究[J]. 中国药学杂志, 2011, 46(5): 338
FENG WS, CHEN X, ZHENG XK, et al. Study on chemical constituents of honeysuckle [J]. Chin Pharm J, 2011, 46(5): 338
[34] 王琦. 金银花的化学成分研究[D]. 沈阳:沈阳药科大学, 2008
WANG Q. Study on Chemical Constituents of Honeysuckle [D]. Shenyang: Shenyang Pharmceutical University, 2008
[35] 魏晓芳, 沈婉莹, 李阳芳, 等. 金银花黄酮苷类化学成分研究[J]. 中草药, 2023, 54(11): 3424
WEI XF, SHEN WY, LI YF, et al. Study on chemical constituents of flavonoid glycosides of honeysuckle [J]. Chin Tradit Herb Drugs, 2023, 54(11): 3424
[36] 倪付勇, 温建辉, 李明, 等. 金银花化学成分研究[J]. 中草药, 2017, 48(18): 3689
NI FY, WEN JH, LI M, et al. Study on chemical constituents of honeysuckle [J]. Chin Tradit Herb Drugs, 2017, 48(18): 3689
[37] 马俊利. 忍冬叶化学成分的研究[D]. 沈阳: 沈阳药科大学, 2009
MA JL. Study on Chemical Constituents of Honeysuckle Leaves [D]. Shenyang: Shenyang Pharmceutical University, 2009
[38] 马俊利. 忍冬叶化学成分研究[J]. 中国实验方剂学杂志, 2013, 19(8): 95
MA JL. Study on chemical constituents of honeysuckle leaves [J]. Chin J Exp Tradit Med Form, 2013, 19(8): 95
[39] KUMAR N, SINGH B, BHANDARI P, et al. Biflavonoids from Lonicera japonica [J]. Phytochemistry, 2005, 66(23): 2740
[40] 鲍学梅, 乔金为, 左亚峰. 金银花化学成分的研究[J]. 中成药, 2022, 44(5): 1501
BAO XM, QIAO JW, ZUO YF. Study on chemical constituents of honeysuckle [J]. Chin Tradit Pat Med, 2022, 44(5): 1501
[41] LIU ZX, LIU CT, LIU QB, et al. Iridoid glycosides from the flower buds of Lonicera japonica and their nitric oxide production and α-glucosidase inhibitory activities[J]. J Funct Foods, 2015, 6(18): 512
[42] KUWAJIMA H, MATSUUCHI K, TAKAISHI K, et al. A secoiridoid glucoside from Ligustrum japonicum [J]. Phytochemistry, 1989, 28(5): 1409
[43] LI YM, JIANG SH, GAO WY, et al. Iridoid glycosides from Scrophularia ningpoensis [J]. Phytochemistry, 1999, 50(1): 101
[44] 刘松涛,杨琳, 王松, 等. 金银花的化学成分研究[J]. 中医药信息, 2020, 37(5): 18
LIU ST, YANG L, WAMG S, et al. The chemical composition of flos lonicerae study [J]. Inf Tradit Chin Med, 2020, 37(5): 18
[45] CHEN B, LIU Y, LIU H W, et al. Iridoid and aromatic glycosides from Scrophularia ningpoensis Hemsl. and their inhibition of [Ca2+] increase induced by KCl [J]. Chem Biodivers, 2008, 5(9): 1723
[46] YU Y, SONG WX, ZHU CG, et al. Homosecoiridoids from the flower buds of Lonicera japonica [J]. J Nat Prod, 2011, 74(10): 2151
[47] SONG WX, LI S, WANG S, et al. Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica [J]. J Nat Prod, 2008, 71(5): 922
[48] LIU J, ZHANG J, WANG F, et al. New secoiridoid glycosides from the buds of Lonicera macranthoides [J]. Nat Prod Commun, 2012, 7(12): 1561
[49] 王芳,蒋跃平,王晓良, 等. 金银花的化学成分研究[J]. 中国中药杂志, 2013, 38(9): 1378
WANG F, JIANG YP, WANG XL, et al. Study on chemical constituents of honeysuckle [J]. China J Chin Mater Med, 2013, 38(9): 1378
[50] 毕跃峰, 田野, 裴姗姗, 等. 金银花中裂环环烯醚萜苷类化学成分研究[J]. 中草药, 2008, 39(1): 18
BI YF, TIAN Y, PEI SS, et al. Study on the chemical constituents of schizocyclic iridoid glycosides in Flos Lonicera [J]. Chin Tradit Herb Drugs, 2008, 39(1): 18
[51] 田野. 金银花化学成分研究[D]. 郑州:郑州大学, 2007
TIAN Y. Study on Chemical Constituents of Honeysuckle [D]. Zhengzhou: Zhengzhou University, 2007
[52] KAWAI H, KUROYANAGI M, UENO A. Iridoid glucosides from Lonicera japonica Thunb. [J]. Chem Pharm Bull, 1988, 36(9): 3664
[53] KASHIWADA Y, OMICHI Y, KURIMOTO S, et al. Conjugates of a secoiridoid glucoside with a phenolic glucoside from the flower buds of Lonicera japonica Thunb. [J]. Phytochemistry, 2013, 96(1): 423
[54] 于洋, 宋卫霞, 郭庆兰, 等. 金银花水提取物的化学成分研究[J]. 中国中药杂志, 2015, 40(17): 3496
YU Y, SONG WX, GUO QL, et al. Study on chemical constituents of Honeysuckle [J]. China J Chin Mater Med, 2015, 40(17): 3496
[55] YANG R, FANG L, LI J, et al. Separation of five iridoid glycosides from Lonicerae Japonicae Flos using high-speed counter-current chromatography and their anti-inflammatory and antibacterial activities [J]. Molecules, 2019, 24(1): E197
[56] 王燕. 金银花水溶性化学成分研究[D]. 长沙:湖南中医药大学, 2008
WANG Y. Study on Water-soluble Chemical Constituents of Flos Lonicerae [D]. Changsha: Hunan University of Traditional Chinese Medicine, 2008
[57] MACHDA K, SASAKI H, LIJIMA T, et al. Studies on the constituents of Lonicera species. Ⅹ Ⅶ . New iridoid glycosides of the stems and leaves of Lonicera japonica Thumb[J]. Chem Pharm Bull, 2002, 50(8): 1041
[58] JAISWALl R, MULLER H, MULLER A, et al. Identification and characterization of chlorogenic acids, chlorogenic acid glycosides and flavonoids from Lonicera henryi L. (caprifoliaceae) leaves by LC-MSn [J]. Phytochemistry, 2014, 35(8): 252
[59] 贺清辉, 田艳艳, 李会军, 等. 红腺忍冬藤茎中环烯醚萜苷类化合物的研究[J]. 中国药学杂志, 2006, 25(9): 656
HE QH, TIAN YY, LI HJ, et al. Studies on iridoid glycosides in the stems of honeysuckle rubroglandulae [J]. Chin Pharm J, 2006, 25(9): 656
[60] 董俊丽, 黄传奇, 王富乾, 等. 灰毡毛忍冬花蕾中三萜皂苷类化学成分研究[J]. 中草药, 2018, 49(19): 4484
DONG JL, HUANG CQ, WANG FQ, et al. Study on the chemical constituents of triterpenoid saponins in honeysuckle flower buds [J]. Chin Tradit Herb Drugs, 2018, 49(19): 4484
[61] 陈昌祥, 王薇薇, 倪伟, 等. 金银花花蕾中的新三萜皂甙[J]. 云南植物研究, 2000, 18(2): 201
CHEN CX, WANG WW, NI W, et al. New triterpenoid saponins from the flower buds of honeysuckle [J]. Yunnan Plant Res, 2000, 35(2): 201
[62] LIU X, ZHOU R, SHEN B, et al. Determination and isolation offour anti-tumour saponins from Lonicera macranthoides by HPLC-ESI-QTOF/MS and HSCCC [J]. Curr Pharm Biotechnol, 2017, 18(13): 1106
[63] LIN LM, ZHANG XG, ZHU JJ, et al. Two new triterpenoid saponins from the flowers and buds of Lonicera japonica [J]. J Asian Nat Prod Res, 2008, 10(10): 925
[64] 刘艳萍, 王云, 贾哲, 等. 基于GC-MS和多元统计方法分析不同产地金银花挥发性成分的差异[J]. 中国中药杂志,2022,47(20):5508
LIU YP, WANG Y, JIA Z, et al. Analysis of volatile components of Flos Lonicerae from different habitats based on GC-MS and multivariate statistical method [J]. China J Chin Mater Med,2022,47(20):5508
[65] 蒲俊杰, 刘谦, 李佳, 等. 金银花不同发育时期挥发性成分的HS-SPME-GC-MS分析[J]. 中草药, 2022, 53(9): 2818
PU JJ, LIU Q, LI J, et al. HS-SPME-GC-MS analysis of volatile components of Flos Lonicerae at different developmental stages [J]. Chin Tradit Herb Drugs, 2022, 53(9): 2818
[66] 夏爱清, 王彦娜, 邢翠娟, 等. 微波萃取-水蒸气蒸馏纯化测定金银花挥发油成分[J]. 山东化工, 2018, 47(10): 51
XIA AQ, WANG YN, XIN CJ, et al. Microwave extraction-determination of water vapor distillation purification honeysuckle naphtha composition [J]. Shandong Chem Ind, 2018, 47(10): 51
[67] 刘慧敏, 杨广德, 李聪, 等. β-葡萄糖苷酶对市售干燥金银花中挥发油成分的影响[J]. 中南药学, 2020, 18(10): 1716
LIU HM, YANG GD, LI C, et al. Effect of β-glucosidase on volatile oil components in dried honeysuckle [J]. Cent South Pharm, 2020, 18(10): 1716
[68] 寿璐佳, 赵晨阳, 颜世利, 等. GC-MS指纹图谱结合化学计量学分析不同产地金银花挥发油的成分变化[J]. 沈阳药科大学学报, 2022, 39(8): 913
SHOU LJ, ZHAO CY, YAN SL, et al. Analysis on the composition of volatile oil of Flos Lonicera from different producing areas by GC-MS fingerprint combined with stoichiometry [J]. J Shenyang Pharm Univ, 2022, 39(8): 913
[69] 肖敏, 谭红军, 李晓华, 等. 金银花叶挥发油的GC-MS分析[J]. 安徽农业科学, 2013, 41(3): 947
XIAO M, TAN HJ, LI XH, et al. GC-MS analysis of volatile oils in honeysuckle leaves[J]. Anhui Agric Sci, 2013, 41(3): 947
[70] 钟玲, 徐婷. 超临界CO2萃取金银花叶中绿原酸及挥发油成分研究[J]. 亚太传统医药, 2013, 9(2): 43
ZHONG L, XU T. Extraction of chlorogenic acid and volatile oil from honeysuckle leaves by supercritical CO2 [J]. Asia Pac Tradit Med, 2013, 9(2): 43
[71] 杨迺嘉, 刘文炜, 霍昕, 等. 忍冬藤挥发性成分研究[J]. 生物技术, 2008, 56(3): 53
YANG NJ, LIU WW, HUO X, et al. Study on volatile components of honeysuckle vine [J]. Biotechnology, 2008, 56(3): 53
[72] 王书妍, 翁慧, 张力, 等. 忍冬藤挥发油化学成分GC/MS分析[J]. 内蒙古民族大学学报(自然科学版), 2011, 26(1): 18
WANG SY, WEN H, ZHANG L, et al. GC/MS analysis of volatile oils from honeysuckle vine [J]. J Inner Mongolia Minzu Univ (Nat Sci), 2011, 26(1): 18
[73] 武雪芬, 李玉贤, 魏炜. 金银花越冬老叶有效成分测定[J]. 中药材, 1997, 20(1): 6
WU XF, LI YX, WEI W. Determination of active components in the old leaves of honeysuckle [J]. J Chin Med Mater, 1997, 20(1): 6
[74] 甄亚钦, 冯玉, 田伟, 等. 忍冬不同部位UPLC指纹图谱及化学模式识别研究[J]. 中草药, 2019, 50(18): 4449
ZHEN YQ, FENG Y, TIAN W, et al. Study on UPLC fingerprint and chemical pattern recognition of different parts of Radix Japonicae[J]. Chin Tradit Herb Drugs, 2019, 50(18): 4449
[75] 韩树. 忍冬茎叶化学成分及其抑菌活性的研究[D]. 咸阳:西北农林科技大学, 2008
HAN S. Study on Chemical Constituents and Antibacterial Activities of the Stems and Leaves of Honeysuckle [D]. Xianyang: Northwest A&F University, 2008
[76] YAN L, XIE Y, WANG Y, et al. Variation in contents of active components and antibacterial activity in different parts of Lonicera japonica Thunb. [J]. Asian Biomed, 2020, 14(1): 19
[77] GENG JL, LI HB, LIU WJ, et al. Two new chemical constituents from Lonicera japonica [J]. Nat Prod Res, 2021, 36(20): 1
[78] 肖作为, 谢梦洲, 甘龙, 等. 山银花、金银花中绿原酸和总黄酮含量及抗氧化活性测定[J]. 中草药, 2019, 50(1): 210
XIAO ZW, XIE MZ, GAN L, et al. Determination of chlorogenic acid and total flavonoids and antioxidant activity in Flos lonicerae flos and Flos lonicerae flos [J]. Chin Tradit Herb Drugs, 2019, 50(1): 210
[79] JUNGU LA,YU-RA KA,YOUNG JKB. Nutraceuticals and antioxidant properties of Lonicera japonica Thunb. as affected by heating time [J]. Int J Food Prop, 2019, 22(1): 630
[80] 杨红文, 彭福润. 纤维素酶法提取金银花中绿原酸工艺优化及其抗氧化活性[J]. 食品研究与开发, 2022, 43(4): 64
YANG HW, PENG FR. Optimization of chlorogenic acid extraction from honeysuckle by cellulase and its antioxidant activity [J]. Food Res Dev, 2022, 43(4): 64
[81] CAO WW, CHEN JL, LI LL, et al. Cookies fortified with Lonicera japonica Thunb. extracts: impact on phenolic acid content, antioxidant activity and physical properties [J]. Molecule, 2022, 27(15): 5033
[82] 罗磊, 张冰洁, 韦倩倩, 等. 金银花黄酮对过氧化氢诱导RAW264.7巨噬细胞损伤的保护作用[J]. 中国食品学报, 2019, 19(5): 18
LUO L, ZHANG BJ, WEI QQ, et al. Protective effect of honeysuckle flavonoids on RAW264.7 macrophage injury induced by hydrogen peroxide [J]. Chin J Food Sci, 2019, 19(5): 18
[83] HAN YF, DONG GZ, CHUAN PZ, et al. Metabolite profiles and antibacterial and antioxidant activities of leaf extracts of five Lonicera species: a comparative study [J]. Chem Bio Technol Ag, 2023, 10(1): 91
[84] XU N, DU LH, CHEN YC, et al. Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments [J]. R Soc Chem, 2023, 13(11): 15379
[85] 张甜甜, 张媛媛, 陈红鸽, 等. 基于微量量热法的金银花抗菌活性部位初筛[J]. 解放军药学学报, 2011, 27(3): 205
ZHANG TT, ZHANG YY, CHEN HG, et al. Preliminary screening of antibacterial active parts of honeysuckle based on microcalorimetry[J]. Pharm J Chin PLA, 2011, 27(3): 205
[86] 任瓯越, 钟辉辛, 孙辉, 等. 金银花精油微胶囊复合/PLA熔喷非织造材料的制备及其抗菌性能[J]. 浙江理工大学学报(自然科学版),2022,47-48(5):465
REN OY, ZHONG HX, SUN H, et al. Preparation and antibacterial properties of honeysuckle essential oil microcapsule composite/PLA melt-blown nonwoven material [J]. J Zhejiang Sci-Tech Univ (Nat Sci),2022,47-48(5):465
[87] 曾华倩, 毛玲, 晋雅恒, 等. 金银花对变异链球菌UA159体外作用的实验研究[J]. 口腔疾病防治, 2022, 30(8): 542
ZENG HQ, MAO L, JIN YH, et al. Effect of honeysuckle flower on Streptococcus mutans UA159 in vitro[J]. J Prev Treat Stomatol Dis, 2022, 30(8): 542
[88] 吕归红, 陈宇. 金银花枝叶提取液体外抑菌活性与体内抗炎作用研究[J]. 浙江中医杂志, 2021, 56(8): 620
LÜ GH, CHEN Y. Study on antibacterial activity in vitro and anti-inflammatory effect in vivo of extracts from the branches and leaves of Honeysuckle [J]. J Zhejiang Tradit Chin Med, 2021, 56(8): 620
[89] 汪晓露, 付畅, 赵勇, 等. 中药金银花治疗新型冠状病毒肺炎机制探究[J]. 中药材, 2020, 43(9): 2340
WANG XL, FU C, ZHAO Y, et al. Mechanism of Chinese medicine honeysuckle in treating novel coronavirus pneumonia [J]. J Chin Med Mater, 2020, 43(9): 2340
[90] 刘畅, 周枝, 尹志刚, 等. 基于网络药理学和分子对接技术探究金银花入血成分干预新型冠状病毒肺炎的作用机制[J]. 现代药物与临床, 2022, 37(2): 264
LIU C, ZHOU Z, YIN ZG, et al. Based on the network pharmacology and molecular docking technology to explore the mechanism of intervention of honeysuckle into blood component in novel coronavirus pneumonia [J]. Mod Med Clin, 2022, 37(2): 264
[91] 杨兰, 钟晓红, 张志旭, 等. 清热解毒经典药对金银花-连翘干预新型冠状病毒肺炎分子机制及相须配伍实质[J]. 辽宁中医药大学学报, 2022, 24(6): 109
YANG L, ZHONG XH, ZHANG ZX, et al. Molecular mechanism and essential compatibility of classical drugs for clearing heat and detoxifying on the intervention of honeysuckle and forsythia in novel coronavirus pneumonia [J]. J Liaoning Univ Chin Med, 2022, 24(6): 109
[92] 李泽宇, 郝二伟, 曹瑞, 等. 药食同源中药防治现代病毒性疫病的应用规律及机制分析[J]. 中草药, 2022, 53(15): 4781
LI ZY, HAO EW, CAO R, et al. Application law and mechanism analysis of traditional Chinese medicine with same origin of medicine and food in prevention and treatment of modern viral diseases [J]. Chin Tradit Herb Drugs, 2022, 53(15): 4781
[93] 马双成, 刘燕, 毕培曦, 等.金银花药材中抗呼吸道病毒感染的环烯醚萜苷类成分的定量研究[J]. 药物分析杂志, 2006, 26(8): 1039
MA SC, LIU Y, BI PX, et al. Quantitative study on the iridoid glycosides of honeysuckle against respiratory virus infection [J]. Chin J Pharm Anal, 2006, 26(8): 1039
[94] LEE YR, YEH SF, RUAN XM, et al. Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis [J]. J Ethnopharmacol, 2017, 19(8): 109
[95] LEE YR, CHANG CM, YEH YC, et al. Honeysuckle aqueous extracts induced let-7a suppress EV71 replication and pathogenesis in vitro and in vivo and is predicted to inhibit SARS-CoV-2 [J]. Viruses, 2021, 13(2): 308
[96] 葛雄, 刘亮, 王赛, 等.金银花黄酮类提取物对血管紧张素Ⅱ诱导的大鼠心肌成纤维细胞增殖和胶原合成的影响[J]. 中西医结合心脑血管病杂志, 2018, 16(20): 2951
GE X, LIU L, WANG S, et al. Effects of flavonoid extract of hoheysuckle on angiotensin Ⅱ induced proliferation and collagen synthesis of rat myocardial fibroblasts [J]. Chin J Integr Med Cardio/Cerebrovasc Dis, 2018, 16(20): 2951
[97] WANG GF, SHI LP, REN YD. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro [J]. Antivir Res, 2009, 83(2): 186
[98] PARK SI, LEE YJ, CHOI SH, et al. Therapeutic effects of blue honeysuckle on lesions of hyperthyroidism in rats [J]. Am J Chin Med, 2016, 44(7): 1441
[99] ZHAO ZL, ZHANG HJ, WANG MQ, et al. The ethanol extract of honeysuckle stem modulates the innate immunity of Chinese mitten crab Eriocheir sinensis against Aeromonas hydrophila [J]. Fish Shellfish Immunol, 2018, 82 (7): 304
[100] ZHANG DF, ZHOU ZE, DU J, et al. Evaluation of antibacterial and antifungal properties of Lonicera japonica Thunb. leaves mediated silver nanoparticles and mechanism investigation [J]. J Food Process Press, 2022, 9(1): 16896
[101] 朱炯霖, 李红, 秦圆, 等. 金银花提取物制备纳米银及其对织物的抗菌性能[J]. 大连工业大学学报, 2021, 40(5): 339
ZHU JL, LI H, QIN Y, et al. Preparation of nano silver from Honeysuckle extract and its antibacterial properties on fabrics [J]. J Dalian Polytech Univ, 2021, 40(5): 339
[102] 张泽生, 王春龙, 徐梦莹, 等. 枸杞金银花红茶菌复合饮料的研制[J]. 中国食品添加剂, 2016, 35(10): 112
ZHANG ZS, WANG CL, XU MY, et al. Study on the development of compound beverage of Chinese wolfberry and honeysuckle [J]. China Food Addit, 2016, 35(10): 112
[103] 张浩, 赵影, 郑欣瑶, 等. 金银花菊花木糖醇复合保健饮料的研究[J]. 农产品加工, 2018, 12(13): 11
ZHANG H, ZHAO Y, ZHEN XY, et al. Study on compound health drink of honeysuckle chrysanthemum xylitol [J]. Prod Process, 2018, 12(13): 11
[104] 王冬雪, 陈凤真, 李阁, 等. 金银花夏枯草鸡蛋花复合饮料研制及其抗氧化活性研究[J]. 食品安全质量检测学报, 2022, 13(10): 3335
WANG DX, CHEN FZ, LI G, et al. Study on antioxidant activity and preparation of complex beverage of honeysuckle and Frangeria chinensis [J]. J Food Saf Qual Insp, 2022, 13(10): 3335
[105] 邓明玉, 冯健如, 宋凤兰, 等. 金银花黄芪抗衰老面膜的制备[J]. 广东化工, 2018, 45(7): 96
DENG MY, FEN JR, SONG FL, et al. Preparation of honeysuckle astragalus anti-aging mask [J]. Guangdong Chem Ind, 2018, 45(7): 96
[106] 梁芸, 南蓬. 银花提取物在乳液化妆品中的抑菌活性及应用[J]. 广东化工, 2016, 43(23): 1
LIANG Y, NAN P. Antibacterial activity and application of extract of honeysuckle in emulsion cosmetics [J]. Guangdong Chem Ind, 2016, 43(23): 1
[107] 王婷, 马啸. 自拟金银花漱口液对呼吸衰竭患者口腔护理的效果观察[J]. 湖南中医杂志, 2018, 34(11): 93
WANG T, MA X. Effect of self-made honeysuckle mouthwash on oral care of patients with respiratory failure [J]. J Hunan Tradit Chin Med, 2018, 34(11): 93
[108] 陆祖瑜, 濮春娟, 刘莎, 等. 不同种类中药废弃物和中药复方的体外抑菌试验[J]. 中国兽医杂志, 2022, 58(1): 85
LU ZY, PU CJ, LIU S, et al. Antibacterial test of different kinds of Chinese medicine waste and Chinese medicine compound in vitro [J]. Chin J Vet Med, 2022, 58(1): 85
[109] 陈两绵, 邹芳艳, 刘晓谦, 等. 3种检测方法比较忍冬药用和非药用部位的抗氧化活性[J]. 世界中医药, 2021, 16(17): 2513
CHEN LM, ZOU FY, LIU XQ, et al. Three methods were used to compare the antioxidant activity of medicinal and non-medicinal parts of honeysuckle [J]. World Chin Med, 2021, 16(17): 2513
文章导航

/