[1] 刘尽美, 王清亮, 姚天文, 等. 甘草应用分布及用量规律研究[J]. 中华中医药学刊, 2014, 32(12): 3021
LIU JM, WANG QL, YAO TW, et al. Research on distribution and dosage of liquorice[J]. Chin Arch Tradit Chin Med, 2014, 32(12): 3021
[2] 万修福, 杨野, 康传志, 等. 林草中药材生态种植现状分析及展望[J]. 中国现代中药, 2021, 23(8): 1311
WAN XF, YANG Y, KANG CZ, et al. Current situation and future perspectives of ecological planting of Chinese medicinal plants in forests and grasslands[J]. Mod Chin Med, 2021, 23(8): 1311
[3] 边育红, 王丽, 张晓雨, 等. 甘草产业链的现状与技术提升[J]. 天津中医药大学学报, 2020, 39(1): 19
BIAN YH, WANG L, ZHANG XY, et al. Current situation and technology improvement of licorice industry chain[J]. J Tianjin Univ Tradit Chin Med, 2020, 39(1): 19
[4] 范铭, 曹爱农, 晋小军, 等. 陇中半干旱地区不同年限甘草生长与有效成分积累动态研究[J]. 西北农业学报, 2016, 25(10): 1522
FAN M, CAO AN, JIN XJ, et al. Growth and accumulation of active components of licorice in different growth years in seiarid region of middle of Gansu province[J]. Acta Agric Boreali-Occident Sin, 2016, 25(10): 1522
[5] 黄帅, 元林, 马淼. 不同种植年限的光果甘草对人乳腺癌细胞增殖抑制作用的研究[J]. 石河子大学学报(自然科学版), 2009, 27(5): 571
HUANG S, YUAN L, MA M. Comparative studies on the anti-proliferation effects of Glycyrrhiza glabra with different living span on human breast cancer BCAP cell[J]. J Shihezi Univ (Nat Sci), 2009, 27(5): 571
[6] 李娜, 张晨, 钟赣生, 等. 不同品种甘草化学成分、药理作用的研究进展及质量标志物(Q-Marker)预测分析[J]. 中草药, 2021, 52(24): 7680
LI N, ZHANG C, ZHONG GS, et al. Research progress on chemical constituents and pharmacological effects of different varieties of Glycyrrhizae Radix et Rhizoma and predictive analysis of quality markers[J]. Chin Tradit Herb Drugs, 2021, 52(24): 7680
[7] 陈佳, 杨蕊, 张权, 等. HPLC结合化学计量学方法用于不同生长年限甘草药材黄酮类成分特征图谱研究[J]. 中国药学杂志, 2020, 55(17): 1415
CHEN J, YANG R, ZHANG Q, et al. Specific chromatograms of Glycyrrhiza uralensis Fisch. flavonoids in different growth years by HPLC coupled with chemometric analysis[J]. Chin Pharm J, 2020, 55(17): 1415
[8] 薄颖异, 张鲁, 常冠华, 等. 不同生长期甘草地上部分黄酮类化合物的含量研究[J]. 西北药学杂志, 2020, 35(5): 639
BO YY, ZHANG L, CHANG GH, et al. Research on the content variation of flavonoids in the aerial parts of Glcyrrhiza uralensis during different growth periods[J]. Northwest Pharm J, 2020, 35(5): 639
[9] 刘贤青, 罗杰. 植物代谢组学技术研究进展[J]. 科技导报, 2015, 33(16): 33
LIU XQ, LUO J. Advances of technologies and research in plant metabolomics[J]. Sci Technol Rev, 2015, 33(16): 33
[10] 田淑云, 廖朝华, 周紫薇, 等. 植物代谢组学在药材质量评价中的研究进展与展望[J]. 药学学报, 2022, 57(6): 1734
TIAN SY, LIAO CH, ZHOU ZW, et al. Research progress and prospects for the use of plant metabolomics in quality evaluation of traditional Chinese medicinal materials[J]. Acta Pharm Sin, 2022, 57(6): 1734
[11] LIAO WC, LIN YH, CHANG TM, et al. Identification of two licorice species, Glycyrrhiza uralensis and Glycyrrhiza glabra, based on separation and identification of their bioactive components[J]. Food Chem, 2012, 132(4): 2188
[12] WANG CC, CAI ZC, SHI JJ, et al. Comparative metabolite profiling of wild and cultivated licorice based on ultra-fast liquid chromatography coupled with triple quadrupole-time of flight tandem mass spectrometry[J]. Chem Pharm Bull, 2019, 67(10): 1104
[13] 文旺, 李莉, 李德坤, 等. 基于液质联用技术和植物代谢组学的甘草炮制品化学成分差异性分析[J]. 中国实验方剂学杂志, 2020, 26(17): 104
WEN W, LI L, LI DK, et al. Analysis of chemical variability on different processed products of Glycyrrhiza uralensis dry roots and rhizomes based on UPLC-Q-TOF-MSE and plant metabolomics[J]. Chin J Exp Tradit Med Form, 2020, 26(17): 104
[14] 吴昊, 于小红, 马光朝, 等. 基于LC-MS的甘草炮制雷公藤降低肝毒性的代谢组学研究[J]. 中草药, 2020, 51(21): 5501
WU H, YU XH, MA GC, et al. Metabolomics study on reduction of hepatotoxic of Tripterygium wilfordii processed by liquorice based on LC-MS[J]. Chin Tradit Herb Drugs, 2020, 51(21): 5501
[15] CHEN W, GONG L, GUO Z, et al. A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics[J]. Mol Plant, 2013, 6(6): 1769
[16] 高渐飞, 周玮, 刘妮, 等. 基于代谢组学分析黑老虎植株不同部位黄酮类成分[J]. 广西植物, 2022, 42(7): 1193
GAO JF, ZHOU W, LIU N, et al. Analysis of flavonoids in different tissues of Kadsura coccinea plant by widely-targeted metabolomics[J]. Guihaia, 2022, 42(7): 1193
[17] FRAE CG, CLOWERS BH, MOORE RJ, et al. Signature-discovery approach for sample matching of a nerve-agent precursor using liquid chromatography-mass spectrometry, XCMS, and chemometrics[J]. Anal Chem, 2010, 82(10): 4165
[18] SONG W, QIAO X, CHEN K, et al. Biosynthesis-based quantitative analysis of 151 secondary metabolites of licorice to differentiate medicinal Glycyrrhiza species and their hybrids[J]. Anal Chem, 2017, 89(5): 3146
[19] 李震宇, 段亚辉, 秦雪梅, 等. 中药质量差异性研究的思考[J]. 药学学报, 2017, 52(12): 1820
LI ZY, DUAN YH, QIN XM, et al. Study of difference in quality of traditional Chinese medicines[J]. Acta Pharm Sin, 2017, 52(12): 1820
[20] 中华人民共和国药典 2020年版. 一部[S]. 2020: 88
ChP 2020. VolⅠ[S]. 2020: 88
[21] 姚玲玲, 柯昌强, 刘佳, 等. 不同炮制程度中药饮片蜜炙甘草的次生代谢化学成分组学研究[J]. 药学学报, 2021, 56(5): 1444
YAO LL, KE CQ, LIU J, et al. Metabolomic investigation of secondary metabolites of prepared slices of Glycyrrhiza uralensis with different degrees of honey processing[J]. Acta Pharm Sin, 2021, 56(5): 1444
[22] 杨瑞, 李文东, 袁伯川, 等. 3种不同基原甘草中18α-甘草酸与18β-甘草酸的含量分析[J]. 药物分析杂志, 2016, 36(6): 1065
YANG R, LI WD, YUAN BC, et al. Simultaneous determination of 18α-glycyrrhizic acid and 18β-glycyrrhizic acid in three licorice samples from different origin by HPLC[J]. Chin J Pharm Anal, 2016, 36(6): 1065
[23] 杨瑞, 李文东, 马永生, 等. 不同基原甘草的分子鉴定及市售甘草药材的质量评价[J]. 药学学报, 2017, 52(2): 318
YANG R, LI WD, MA YS, et al. The molecular identification of licorice species and the quality evaluation of licorice slices[J]. Acta Pharm Sin, 2017, 52(2): 318
[24] 李泽宇, 郝二伟, 李卉, 等. 甘草配伍应用的药理作用及机制分析[J]. 中国实验方剂学杂志, 2022, 28(14): 270
LI ZY, HAO EW, LI H, et al. Pharmacological effect of Glycyrrizae Radix et Rhizoma compatibility and its mechanism[J]. Chin J Exp Tradit Med Form, 2022, 28(14): 270
[25] SEO JH, CHOI HW, OH HN, et al. Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma[J]. J Cell Physiol, 2019, 234(2): 1780
[26] KIM SS, LIM J, BANG Y, et al. Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease[J]. J Nutr Biochem, 2012, 23(10): 1314
[27] LIN Y, KUANG Y, LI K, et al. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata[J]. Bioorg Med Chem, 2017, 25(14): 3706
[28] MEDEIROS DL, LIMA ETG, SILVA JC, et al. Rhamnetin: a review of its pharmacology and toxicity[J]. J Pharm Pharmacol, 2022, 74(6): 793
[29] ZHENG YF, WEI JH, FANG SQ, et al. Hepatoprotective triterpene saponins from the roots of Glycyrrhiza inflata[J]. Molecules, 2015, 20(4): 6273
[30] MITREGA K, ZORNIAK M, VARGHESE B, et al. Beneficial effects of L-leucine and L-valine on arrhythmias, hemodynamics and myocardial morphology in rats[J]. Pharmacol Res, 2011, 64(3): 218
[31] 李宣, 何迎春, 周芳亮. 山楂酸药理作用及其机制的研究进展[J]. 中国现代医学杂志, 2021, 31(8): 49
LI X, HE YC, ZHOU FL. Research advance or pharmacological effects and mechanisms of maslinic acid[J]. China J Mod Med, 2021, 31(8): 49
[32] 庞溢媛, 薛立英, 郑艳红, 等. 基于UHPLC-MS/MS代谢组学技术的不同采收期黄芩质量比较研究[J]. 药学学报, 2017, 52(12): 1903
PANG YY, XUE LY, ZHENG YH, et al. Comparative study on quality of Scutellaria baicalensis Georgi in different harvest periods using UHPLC-MS/MS metabolomics technology[J]. Acta Pharm Sin, 2017, 52(12): 1903
[33] TANAKA Y, BRUGLIERA F, KALC G, et al. Flower color modification by engineering of the flavonoid biosynthetic pathway: practical perspectives[J]. Biosci Biotechnol Biochem, 2010, 74(9): 1760
[34] 陈亚超, 李楠楠, 刘子迪, 等. 源于甘草内生菌的甘草酸合成相关功能基因的宏基因组挖掘[J]. 中国生物工程杂志, 2021, 41(9): 37
CHEN YC, LI NN, LIU ZD, et al. Metagenomic mining of functional genes related to glyrrhizin synthesis from endophytes licorice[J]. China Biotechnol, 2021, 41(9): 37
[35] 刘春生, 刘颖. 药用植物功能基因的研究思路与展望—以甘草为例[J]. 中国实验方剂学杂志, 2015, 21(1): 1
LIU CS, LIU Y. Research ideas and propects of functional genes involved in medicinal plants, such as Glycyrrhizae Radix et Rhizoma[J]. Chin J Exp Tradit Med Form, 2015, 21(1): 1
[36] MOCHIDA K, SAKURAI T, SEKI H, et al. Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume[J]. Plant J, 2017, 89(2): 181
[37] 刘颖,刘春生. 甘草 β-AS基因时空表达模式研究[J]. 中药材, 2012, 35(4): 528
LIU Y, LIU CS. Study on the spatial and temporal expression of β-AS gene of Glycyrriza uralensis[J]. J Chin Med Mater, 2012, 35(4): 528
[38] 梁浩, 孙海, 钱佳奇, 等. 药用植物代谢调控的组学研究进展[J]. 中药材, 2023(8): 2085
LIANG H, SUN H, QIAN JQ, et al. Progress in histological studies of metabolic regulation in medicinal plants[J]. J Chin Med Mater, 2023(8): 2085
