综述专论

中药软物质科学:传统中药与现代物质科学交叉的新领域*

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  • 1.北京中医药大学 中药学院,北京 102488;
    2.天津中医药大学 中药学院,天津 301617;
    3.湖北大学 化学化工学院,武汉 430062;
    4.中国食品药品检定研究院 中药民族药检定所,北京 102629
第一作者 Tel:(010)53912129; E-mail:liuyuebei_002@163.com
**马双成 Tel:(010)53852076;E-mail:masc@nifdc.org.cn
李 全 Tel:18372161992;E-mail:quanli85@tjutcm.edu.cn

收稿日期: 2022-11-16

  网络出版日期: 2024-06-24

基金资助

*国家自然科学基金资助项目(81903807,81973476,21901067)

Soft Matter Science of Traditional Chinese Medicine: a new frontier at the intersection of traditional Chinese medicine and modern material science*

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  • 1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    2. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;
    3. College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China;
    4. National Institutes for Food and Drug Control, Beijing 102629, China

Received date: 2022-11-16

  Online published: 2024-06-24

摘要

中药药效物质基础研究是推动中药现代化发展的基础和关键。与传统中药药效物质基础“化学分离-结构鉴定-生物活性”的研究模式不同,近年来涌现出了“组分互作-聚集体结构-生物活性”研究的新范式。本文是基于中药药效物质微纳组装的最新研究进展,并以中医药理论的“整体观”和“系统观”为指导,从聚集体的视角出发提出“中药软物质科学”这一新兴交叉学科领域。系统阐述了中药软物质的定义、研究思路和方法、表征技术、研究挑战以及理论和现实意义,希望从不同的角度认识中药治疗疾病的物质基础,同时也希望能为中药药效物质基础研究乃至中药现代化进程提供更广阔的理论和实践平台。

本文引用格式

刘越, 李全, 马双成 . 中药软物质科学:传统中药与现代物质科学交叉的新领域*[J]. 药物分析杂志, 2023 , 43(1) : 45 -50 . DOI: 10.16155/j.0254-1793.2023.01.06

Abstract

Studies of the material basis of traditional Chinese medicine (TCM) are fundamental and critical to the advances of the modernization of TCM. Differing from the traditional research mode of “separation of chemical component-structural identification-bioactivity” for the material basis study of TCM, a new research mode of “component interaction-structure of aggregates-bioactivity” has emerged recently. Based on the recent research development on micro or nano-aggregates from the material basis of TCM, together with the guidance of the integral and systematic view advocated by TCM theory, we herein proposed a new interdisciplinary field as “Soft Matter Science of Traditional Chinese Medicine (SMSTCM)” from the point-view of aggregate science. The definition, study method, characterization techniques, the research challenges, and the theoretical and practical perspectives for the soft matter of TCM were discussed. It is expected that the material basis of TCM for disease treatment will be unraveled from a different point of view. Meanwhile, a more broad theoretical and practical innovation platform is assumed for the continuous research on the material basis of TCM and the modernization of TCM.

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