[1] FAGIOLA M, HAHN T, AVELLA J. Screening of novel psychoactive substances in postmortem matrices by liquid chromatography-tandem mass spectrometry (LC-MS-MS)[J].J Anal Toxicol, 2018, 42(8):562
[2] NAMERA A, KAWAMURA M, NAKAMOTO A, et al. Comprehensive review of the detection methods for synthetic cannabinoids and cathinones[J].Forensic Toxicol, 2015, 33(2):175
[3] The United Nations Office on Drugs and Crime. DATA FROM THE UNODC EARLY WARNING ADVISORY ON NEW PSYCHOACTIVE SUBSTANCES[EB/OL].(2021-08-26)[2021-08-29]. https://www.unodc.org/unodc/en/scientists/ewa/data.html
[4] TANG MHY, LI TC, LAI CK, et al. Emergence of new psychoactive substance 2-fluorodeschloroketamine: toxicology and urinary analysis in a cluster of patients exposed to ketamine and multiple analogues[J].Forensic Sci Int, 2020, 312:110327
[5] CHENG WC, DAO KL. The emergence of deschloro-N-ethyl-ketamine, a ketamine analog, in drug seizures and drug driving cases in Hong Kong[J].J Anal Toxicol, 2020, 44(8):886
[6] MENZIES EL, HUDSON SC, DARGAN PI, et al. Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine[J].Drug Test Anal, 2014, 6(6):506
[7] TANG MHY, CHONG YK, CHAN CY, et al. Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE[J].Forensic Sci Int, 2018, 290:238
[8] CHIAPPINI S, CLARIDGE H, CORKERY JM, et al. Methoxetamine-related deaths in the UK:an overview[J].Human Psychopharmacol Clin Exp, 2015, 30(4):244
[9] ADAMOWICZ P, ZUBA D. Fatal intoxication with methoxetamine[J].J Forensic Sci, 2015, 60:S264
[10] European Monitoring Centre for Drugs and Drug Addiction and EUROPOL. EU Drug Markets Report:a strategic analysis[R].Lisbon, 2013
[11] ZAWILSKA JB. Methoxetamine-a novel recreational drug with potent hallucinogenic properties[J].Toxicol Lett, 2014, 230(3):402
[12] GOMILA I, LECIÑENA MÁ, ELORZA MÁ, et al. Detectability of dissociative psychoactive substances in urine by five commercial phencyclidine immunoassays[J].J Anal Toxicol, 2019, 43(6):497
[13] CHENG WJ, CHEN CH, CHEN CK, et al. Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia[J].Schizophr Res, 2018, 199:313
[14] WIKSTRÖM M, THELANDER G, DAHLGREN M, et al. An accidental fatal intoxication with methoxetamine[J].J Anal Toxicol, 2013, 37(1):43
[15] ZANDA MT, FADDA P, CHIAMULERA C, et al. Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects:a review of case reports and preclinical findings[J].Behav Pharmacol, 2016, 27(6):489
[16] DAVIDSEN AB, MARDAL M, HOLM NB, et al. Ketamine analogues:comparative toxicokinetic in vitro-in vivo extrapolation and quantification of 2-fluorodeschloroketamine in forensic blood and hair samples[J].J Pharm Biomed Anal, 2020, 180:113049
[17] CELIA JA, MORGAN H,VALERIE, et al. Ketamine use:a review[J].Addiction,2012,107(1):27
[18] HÁJKOVÁ K, JURÁSEK B, EJKA J, et al. Synthesis and identification of deschloroketamine metabolites in rats’ urine and a quantification method for deschloroketamine and metabolites in rats’ serum and brain tissue using liquid chromatography tandem mass spectrometry[J].Drug Test Anal, 2020, 12(3):343
[19] ACEVEDO-DIAZ EE, CAVANAUGH GW, GREENSTEIN D, et al. Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression[J].J Affective Disord, 2020, 263:568
[20] MORRIS H, WALLACH J. From PCP to MXE:a comprehensive review of the non-medical use of dissociative drugs[J].Drug Test Anal, 2014, 6(7-8):614
[21] ZANOS P, MOADDEL R, MORRIS P J, et al. Ketamine and ketamine metabolite pharmacology:insights into therapeutic mechanisms[J].Pharmacol Rev, 2018, 70(3):621
[22] COSTA G, SERRA M, PINTORI N, et al. The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats[J].Neuropharmacology, 2019, 144:219
[23] KASHIWAZAKI M, NODA K. Effect of ketamine on the excitability of peripheral nerves[J].Masui, 1998, 47(6):696
[24] MORGAN CJA, REES H, CURRAN HV. Attentional bias to incentive stimuli in frequent ketamine users[J].Psychol Med, 2008, 38(9):1331
[25] BOTANAS CJ, DE LA PEÑA JB, DELA PENA IJ, et al. Methoxetamine, a ketamine derivative, produced conditioned place preference and was self-administered by rats: evidence of its abuse potential[J].Pharmacol Biochem Behav, 2015, 133:31
[26] Articles about Erowid Experience Reports[EB/OL].[2021-08-15]. https://erowid.org/experiences/
[27] MEYER MR, VOLLMAR C, SCHWANINGER AE, et al. New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone: studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine[J].J Mass Spectrom, 2012, 47(2):253
[28] HORSLEY RR, LHOTKOVA E, HAJKOVA K, et al. Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-behavioural, pharmacokinetic and metabolic studies in the Wistar rat[J].Brain Res Bull, 2016, 126:102
[29] BEY T, PATEL A. Phencyclidine intoxication and adverse effects:a clinical and pharmacological review of an illicit drug[J].Calif J Emerg Med, 2007, 8(1):9
[30] SKAUGEN JM, SCOCCIMARRO A, PIZON AF, et al. Novel ketamine analogues cause a false positive phencyclidine immunoassay[J].Ann Clin Biochem, 2019, 56(5):598
[31] LIU CH, WANG HY, SHEN SH, et al. False positive ketamine urine immunoassay screen result induced by quetiapine:a case report[J].J Formos Med Assoc, 2017, 116(9):720
[32] DE PAOLI G, BRANDT SD, WALLACH J, et al. From the street to the laboratory:analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices[J].J Anal Toxicol, 2013, 37(5):277
[33] THEOFEL N, MÖLLER P, VEJMELKA E, et al. A fatal case involving N-ethyldeschloroketamine (2-oxo-PCE) and venlafaxine[J].J Anal Toxicol, 2019, 43(2):e2
[34] LEHMANN S, SCHULZE B, THOMAS A, et al. Organ distribution of 4-MEC, MDPV, methoxetamine and α-PVP:comparison of QuEChERS and SPE[J].Forensic Toxicol, 2018, 36(2):320
[35] LEHMANN S, KIELIBA T, BEIKE J, et al. Determination of 74 new psychoactive substances in serum using automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry[J].J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1064:124
[36] ANASTASSIADES M, LEHOTAY SJ, TAJNBAHER D, et al. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce[J].J AOAC Int, 2003, 86(2):412
[37] WU H, ZHANG J, NOREM K, et al. Simultaneous determination of a hydrophobic drug candidate and its metabolite in human plasma with salting-out assisted liquid/liquid extraction using a mass spectrometry friendly salt[J].J Pharm Biomed Anal, 2008, 48(4):1243
[38] HAJKOVA K, JURASEK B, SYKORA D, et al. Salting-out-assisted liquid-liquid extraction as a suitable approach for determination of methoxetamine in large sets of tissue samples[J].Anal Bioanal Chem, 2016, 408(4):1171
[39] MIYAGUCHI H, KAKUTA M, IWATA YT, et al. Development of a micropulverized extraction method for rapid toxicological analysis of methamphetamine in hair[J].J Chromatogr A, 2007, 1163(1-2):43
[40] MIYAGUCHI H, INOUE H. Determination of amphetamine-type stimulants, cocaine and ketamine in human hair by liquid chromatography/linear ion trap-orbitrap hybrid mass spectrometry[J].Analyst, 2011, 136(17):3503
[41] FAVRETTO D, VOGLIARDI S, STOCCHERO G, et al. Determination of ketamine and norketamine in hair by micropulverized extraction and liquid chromatography-high resolution mass spectrometry[J].Forensic Sci Int, 2013, 226(1-3):88
[42] WOOD DM, DAVIES S, PUCHNAREWICZ M, et al. Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine[J].Eur J Clin Pharmacol, 2012, 68(5):853
[43] FRISON G, ZAMENGO L, ZANCANARO F, et al. Characterization of the designer drug deschloroketamine (2-methylamino-2-phenylcyclohexanone) by gas chromatography/mass spectrometry, liquid chromatography/high-resolution mass spectrometry, multistage mass spectrometry, and nuclear magnetic resonance[J].Rapid Commun Mass Spectrom, 2016, 30(1):151
[44] IMBERT L, BOUCHER A, DELHOME G, et al. Analytical findings of an acute intoxication after inhalation of methoxetamine[J].J Anal Toxicol, 2014, 38(7):410
[45] GICQUEL T, RICHEVAL C, MESLI V, et al. Fatal intoxication related to two new arylcyclohexylamine derivatives (2F-DCK and 3-MeO-PCE)[J].Forensic Sci Int, 2021:110852
[46] TANG MHY, CHING CK, LEE CYW, et al. Simultaneous detection of 93 conventional and emerging drugs of abuse and their metabolites in urine by UHPLC-MS/MS[J].J Chromatogr B Analyt Technol Biomed Life Sci, 2014, 969:272
[47] SO PK, NG TT, WANG H, et al. Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry[J].Analyst, 2013, 138(8):2239
[48] WIERGOWSKI M, ANAND JS, KRZYPZANOWSKI M, et al. Acute methoxetamine and amphetamine poisoning with fatal outcome:a case report[J].Int J Occup Med Environ Health, 2014, 27(4):683
[49] FASSETTE T, MARTINEZ A. An impaired driver found to be under the influence of methoxetamine[J].J Anal Toxicol, 2016, 40(8):700
[50] ABE E, RICARD F, DARROUZAIN F, et al. An automated method for measurement of methoxetamine in human plasma by use of turbulent flow on-line extraction coupled with liquid chromatography and mass spectrometric detection[J].Anal Bioanal Chem, 2013, 405(1):239
