[1] WILKINS JM, TRUSHINA E. Application of metabolomics in Alzheimer’s disease[J].Front Neurol, 2018, 8: 719
[2] YU MQ, ZHU Y, CONG QW, et al. Metabonomics research progress on liver diseases[J].Cancer J Gastroenterol Hepatol[J].2017, 2017: 8467192
[3] RIBBENSTEDT A, ZIARRUSTA H, BENSKIN JP. Development, characterization and comparisons of targeted and non-targeted metabolomics methods[J].PLoS One, 2018, 13 (11): e0207082
[4] NORELDEEN HAA, LIU X, XU G. Metabolomics of lung cancer: analytical platforms and their applications[J].J Sep Sci, 2020, 43(1): 120
[5] BARZAMAN K, KARAMI J, ZAREI Z, et al. Breast cancer: biology, biomarkers, and treatments[J].Int Immunopharmacol, 2020, 84:106535
[6] BEN HC, GUTIERREZ-PAJARES JL, GUIMARAES C, et al. Apolipoprotein-mediated regulation of lipid metabolism induces distinctive effects in different types of breast cancer cells[J].Breast Cancer Res, 2020, 22 (1): 38
[7] GHANBARI F, FORTIER AM, PARK M, et al. Cholesterol-induced metabolic reprogramming in breast cancer cells is mediated via the erralpha pathway[J].Cancers (Basel), 2021, 13 (11): 2605
[8] WISSAM Z, IMTISSAL A, HANEEN Y. Warburg effects on cancer cells survival: the role of sugar starvation in cancer therapy[J].Curr Clin Pharmacol, 2020, 16 (1): 30
[9] S TJY, M TG. Molecular classification of breast cancer[J].Adv Anat Pathol, 2020, 27(1):27
[10] 亓秉超, 薛妍.管腔B型乳腺癌的研究进展[J].肿瘤研究与临床, 2015, 27 (12): 857
QI BC, XUE Y.Research progress of luminal type B breast cancer [J].Tumor Res Clin, 2015, 27 (12): 857
[11] 张换敬, 李怡, 刘国彦, 等.新型靶向治疗人表皮生长因子受体2过表达乳腺癌[J].广东医学, 2013, 34 (3): 476
ZHANG HJ, LI Y, LIU GY, et al. A novel targeted therapy for breast cancer with overexpression of human epidermal growth factor receptor 2 [J].Guangdong Med, 2013, 34 (3): 476
[12] 杨桂仙, 张大方.乳腺癌动物模型的研究现状与评价[J].长春中医药大学学报, 2007, 4 (2): 82-83
YANG GX, ZHANG DF. Research status and evaluation of animal model of breast cancer [J].J Changchun Univ Tradit Chin Med, 2007, 4 (2): 82
[13] 高薇乳腺癌淋巴转移动物模型的建立与评价 [D].银川:宁夏医科大学, 2014
GAO W. Establishment and Evaluation of Animal Model of lymphatic Metastasis of Breast Cancer [D].Yinchuan:Ningxia Medical University, 2014
[14] 于理想, 王峰, 傅勤烨.乳腺癌癌前病变动物模型的建立[J].中国现代普通外科进展, 2014, 17 (11): 886
YU LX, WANG F, FU QY. Establishment of animal model of precancerous lesions of breast cancer [J].Adv Mod Gen Surg China, 2014, 17 (11): 886
[15] 李日飞, 袁娜, 冶冬阳, 等.乳腺癌实验动物模型的研究进展[J].中国比较医学杂志, 2018, 28 (2): 113
LI RF, YUAN N, YE DY, et al. Research progress of experimental animal model of breast cancer [J].Chin J Comp Med, 2018, 28 (2): 113
[16] SUBIK K, LEE JF, BAXTER L, et al. The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines[J].Breast Cancer: Basic Clin Res, 2010, 4: 35
[17] BUSSADOR DAJ, PAULA RT, MORAIS FV, et al. MCF-7 cells as a three-dimensional model for the study of human breast cancer[J].Tissue Engin Part C, Method, 2011, 17 (11): 1097
[18] BURKS HE, MATOSSIAN MD, RHODES LV, et al. ZEB2 regulates endocrine therapy sensitivity and metastasis in luminal a breast cancer cells through A non-canonical mechanism[J].Breast Cancer Res Treat, 2021, 189(1): 25
[19] CRUZ LM, FERREIRA JC, MELLO ML. Apoptotic ratios and mitotic abnormalities in 17-β-estradiol-transformed human breast epithelial MCF-10F cells[J].Braz J Biol, 2011, 71 (2): 487
[20] OMRAN MM, RASHED RE, DARWISH H, et al. Development of a gas chromatography-mass spectrometry method for breast cancer diagnosis based on nucleoside metabolomes 1-methyl adenosine, 1-methylguanosine and 8-hydroxy-2’-deoxyguanosine[J].Biomed Chromatogr, 2020, 34 (1): e4713
[21] RASHED R, DARWIH H, OMRAN M, et al. A novel serum metabolome score for breast cancer diagnosis[J].Br J Biomed Sci, 2020, 77 (4): 196
[22] SHEN J, YAN L, LIU S, et al. Plasma metabolomic profiles in breast cancer patients and healthy controls: by race and tumor receptor subtypes[J].Transl Oncol, 2013, 6 (6): 757
[23] BROCKMÖLLER SF, BUCHER E, MÜLLER BM, et al. Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling[J].J Proteome Res, 2012, 11 (2): 850
[24] MÓNICA C, JULIAN A, JULIÁN S, et al. Urinary metabolite and lipid alterations in Colombian Hispanic women with breast cancer: a pilot study[J].J Pharm Biomed Anal, 2018, 152: 234
[25] JING W, RUI Y, LEI Z, et al. Metabolomics research on potential role for 9-cis-retinoic acid in breast cancer progression[J].Cancer Sci, 2018, 109 (7): 2315
[26] DIAZ-BELTRAN L, GONZALEZ-OLMEDO C, LUQUE-CARO N, et al. Human plasma metabolomics for biomarker discovery: targeting the molecular subtypes in breast cancer[J].Cancers (Basel), 2021, 13(1):147
[27] XAVIER AD, ACEVEDO AC, CANCADO P, et al. Using an untargeted metabolomics approach to identify salivary metabolites in women with breast cancer[J].Metabolites, 2020, 10(12):506
[28] SHARMA U, JAGANNATHAN NR. Breast cancer metabolomics using NMR[J].Methods Mol Biol, 2019, 2037: 195
[29] YANG L, HOU YX, YUAN J, et al. Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways[J].Oncotarget, 2015, 6 (28): 2575
[30] SUN XY, WANG MZ, WANG MS, et al. Metabolic reprogramming in triple-negative breast cancer[J].Front Oncol, 2020, 10:428
[31] KAMIL K, AGNIESZKA K, AGNIESZKA Z, et al. Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics[J].Breast Cancer Res, 2018, 20 (1): 148
[32] REIS SJ, LINETZKY WD, GUERREIRO D, et al. Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: a metabolomic study[J].Oncotarget, 2020, 11 (18): 1637
[33] KOU F, ZHU B, ZHOU W, et al. Targeted metabolomics reveals dynamic portrayal of amino acids and derivatives in triple-negative breast cancer cells and culture media[J].Mol Omics, 2021, 17(1): 142
[34] ZELEZNIK OA, BALASUBRAMANIAN R, ZHAO YB, et al. Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women[J].NPJ Breast Cancer, 2021, 7(1):54
[35] LI AM, DUCKER GS, LI Y, et al. Metabolic profiling reveals a dependency of human metastatic breast cancer on mitochondrial serine and one-carbon unit metabolism[J].Mol Cancer Res, 2020, 18(4): 599
[36] JOBARD E, PONTOIZEAU C, BLAISE BJ, et al. A serum nuclear magnetic resonance-based metabolomic signature of advanced metastatic human breast cancer[J].Cancer Lett, 2014, 343 (1): 33
[37] ZHU GC, XIAO BQ, FANG FL, et al. Tryptophan-induced pathogenesis of breast cancer[J].Afr Health Sci, 2015, 15 (3): 982
[38] KOU F, ZHU BJ, ZHOU WB, et al. Targeted metabolomics in the cell culture media reveals increased uptake of branched amino acids by breast cancer cells[J].Anal Biochem, 2021, 624: 114192
[39] HOU J, REID NE, TROMBERB BJ, et al. Kinetic analysis of lipid metabolism in breast cancer cells via nonlinear optical microscopy[J].Biophys J, 2020, 119 (2): 258
[40] ZHONG LP, CHENG F, LU XY, et al. Untargeted saliva metabonomics study of breast cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations[J].Talanta, 2016, 158: 351
[41] ZHU Z, ZHAO X, ZHAO L, et al. p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A[J].Oncogene, 2016, 35 (11): 1399
[42] TREECK O, SCHULER-TOPRAK S, ORTMANN O. Estrogen actions in triple-negative breast cancer[J].Cells, 2020, 9(11):2358
[43] DALLAL CM, TICE JA, BUIST DS, et al. Estrogen metabolism and breast cancer risk among postmenopausal women: a case-cohort study within B~FIT[J].Carcinogenesis, 2014, 35 (2): 346
[44] PARL FF, DAWLING S, ROODI N, et al. Estrogen metabolism and breast cancer: a risk model[J].Ann N Y Acad Sci, 2009, 1155: 68
[45] GARCÍA-GONZÁLEZ V, DÍAZ-VILLANUEVA JF, GALINDO-HERNÁNDEZ O, et al. Ceramide metabolism balance, a multifaceted factor in critical steps of breast cancer development[J].Int J Mol Sci, 2018, 19 (9): 2527
[46] MARTEL CD, FERLAY J, FRANCESCHI S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis[J].Lancet Oncol, 2012, 13(6): 607
[47] FERNÁNDEZ MF, REINA-PÉREZ I, ASTORGA JM, et al. Breast cancer and its relationship with the microbiota[J].Int J Environ Res Public Health, 2018, 15(8): 1747
[48] HE C, LIU Y, YE SD, et al. Changes of intestinal microflora of breast cancer in premenopausal women[J].Eur J Clin Microbiol Infect Dis, 2021, 40(3): 503
[49] JIM, SUN LQ, LIU Y, et al. Alter between gut bacteria and blood metabolites and the anti-tumor effects of Faecalibacterium prausnitzii in breast cancer[J].BMC Microbiol, 2020, 20 (1): 82
[50] RAJSKA A, BUSZEWSKA-FORAJTA M, RACHOŃ D, et al. Metabolomic insight into polycystic ovary syndrome—an overview[J].Int J Mol Sci, 2020, 21 (14): 4853
[51] BRADEN AM, STANKOWSKI RV, ENGEL JM, et al. Breast cancer biomarkers: risk assessment, diagnosis, prognosis, prediction of treatment efficacy and toxicity, and recurrence[J].Curr Pharm Des, 2014, 20(30): 4879
[52] ELODIE J, LAURE D, LAURA B, et al. Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case—control study nested within the French E3N cohort[J].Br J Cancer, 2021, 124(10): 1734
[53] GIANMARIA M, ELENA M, DONATELLA C, et al. Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer[J].Oncotarget, 2016, 7 (26): 39809
[54] HELLAND T, HENNE N, BIFULCO E, et al. Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients[J].Breast Cancer Res, 2017, 19 (1): 125
[55] BLOMME A, COSTANZA B, TULLIO P, et al. Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer[J].Oncogene, 2017, 36 (15): 2116
[56] SECHOPOULOS I, TEUWEN J, MANN R. Artificial intelligence for breast cancer detection in mammography and digital breast tomosynthesis: state of the art[J].Semin Cancer Biol, 2021, 72:214
[57] LV W, YANG T. Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC-MS and multivariate statistical analysis[J].Clin Biochem, 2012, 45 (1-2): 127
[58] HADI NI, JAMAL Q, IQBAL A, et al. Serum metabolomic profiles for breast cancer diagnosis, grading and staging by gas chromatography-mass spectrometry[J].Sci Rep, 2017, 7 (1): 1715
[59] CUI M, WANG QL, CHEN G. Serum metabolomics analysis reveals changes in signaling lipids in breast cancer patients[J].Biomed Chromatogr, 2016, 30 (1): 42
[60] PIETZKE M, ARROYO SF, SUMPTON D, et al. Stratification of cancer and diabetes based on circulating levels of formate and glucose[J].Cancer Metab, 2019, 7: 3
[61] WANG XY, ZHAO XS, CHOU J, et al. Taurine, glutamic acid and ethylmalonic acid as important metabolites for detecting human breast cancer based on the targeted metabolomics[J].Cancer Biomark, 2018, 23 (2): 255
[62] ENIU DT, ROMANCIUC F, MORARU C, et al. The decrease of some serum free amino acids can predict breast cancer diagnosis and progression[J].Scand J Clin Lab Invest, 2019, 79 (1-2): 17
[63] WANG QJ, GAO P, SUN T, et al. A dried blood spot mass spectrometry metabolomic approach for rapid breast cancer detection[J].Onco Targets Ther, 2016(9): 1389
[64] YUAN BW, SCHAFFERER S, TANG QQ, et al. A plasma metabolite panel as biomarkers for early primary breast cancer detection[J].Int J Cancer, 2019, 144 (11): 2833
[65] JASBI P, WANG DF, CHEN LH, et al. Breast cancer detection using targeted plasma metabolomics[J].J Chromatogr B Anal Technol Biomed Life Sci, 2019, 1105: 26
[66] XIE GX, ZHOU BS, ZHAO AH, et al. Lowered circulating aspartate is a metabolic feature of human breast cancer[J].Oncotarget, 2015, 6 (32): 33369
[67] QIU YP, ZHOU BS, SU MM, et al. Mass spectrometry-based quantitative metabolomics revealed a distinct lipid profile in breast cancer patients[J].Int J Mol Sci, 2013, 14 (4): 8047
[68] SUMAN S, SHARMA RK, KUMAR V, et al. Metabolic fingerprinting in breast cancer stages through 1H-NMR spectroscopy-based metabolomic analysis of plasma[J].J Pharm Biomed Anal, 2018, 160: 38
[69] ZHAO H, SHEN J, YE YQ, et al. Validation of plasma metabolites associated with breast cancer risk among Mexican Americans[J].Cancer Epidemiol, 2020, 69: 101826
[70] NAM H, CHUNG BC, KIM Y, et al. Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification[J].Bioinformatics, 2009, 25 (23): 3151
[71] GUO MZ, ZHANG LY, DU Y, et al. Enrichment and quantitative determination of 5-(hydroxymethyl)-2’-deoxycytidine, 5-(formyl)-2’-deoxycytidine, and 5-(carboxyl)-2’-deoxycytidine in human urine of breast cancer patients by magnetic hyper-cross-linked microporous polymers based on polyionic liquid[J].Anal Chem, 2018, 90 (6): 3906
[72] WOO HM, KIM KM, CHOI MH, et al. Mass spectrometry based metabolomic approaches in urinary biomarker study of women’s cancers[J].Clin Chim Acta, 2009, 400 (1-2): 63
[73] CHEN YH, ZHANG RP, SONG YM, et al. RRLC-MS/MS-based metabonomics combined with in-depth analysis of metabolic correlation network: finding potential biomarkers for breast cancer[J].Analyst, 2009, 134 (10): 2003
[74] MIMMI MC, FINATO N, PIZZOLATO G, et al. Absolute quantification of choline-related biomarkers in breast cancer biopsies by liquid chromatography electrospray ionization mass spectrometry[J].Anal Cell Pathol (Amst), 2013, 36 (3-4): 71
[75] LI ML, SONG YY, CHO N, et al. An HR-MAS MR metabolomics study on breast tissues obtained with core needle biopsy[J].PLoS One, 2011, 6 (10): e25563
[76] JAN B, M PB, BALAZS G, et al. Glutamate enrichment as new diagnostic opportunity in breast cancer[J].Int J Cancer, 2015, 136 (7): 1619
[77] BUDCZIES J, DENKERT C, MVLLER BM, et al. Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue—a GC-TOFMS based metabolomics study[J].BMC Genomics, 2012, 13: 334
[78] BHADWAL P, DAHIYA D, SHINDE D, et al. LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients[J].Sci Rep, 2020, 10 (1): 4668
[79] NAGANA GG, BARDINGGA J, DAI J, et al. A Metabolomics study of BPTES altered metabolism in human breast cancer cell lines[J].Front Mol Biosci, 2018, 5: 49
[80] 李璐佳, 李国文, 谢燕光.甘草定和槲皮素对乳腺癌细胞能量代谢的调控作用[J].中国中药杂志, 2019, 44 (17): 3786
LI LJ, LI GW, XIE Y. Regulatory effects of glycyrrhizin and quercetin on energy metabolism of breast cancer cells [J].Chin J Tradit Chin Med, 2019, 44 (17): 3786
[81] RAQUEL G, DAVID C, LUISA F, et al. MMP-11 as a biomarker for metastatic breast cancer by immunohistochemical-assisted imaging mass spectrometry[J].Anal Bioanal Chem, 2019, 411 (3): 639
[82] THING TS, OMP, CHRISTINA R, et al. Sialic acid metabolism: a key player in breast cancer metastasis revealed by metabolomics[J].Front Oncol, 2018, 8: 174
[83] KIM HY, LEE KM, KIM SH, et al. Comparative metabolic and lipidomic profiling of human breast cancer cells with different metastatic potentials[J].Oncotarget, 2016, 7 (41): 67111
[84] YANG J, CHEN C, CHEN W, et al. Proteomics and metabonomics analyses of covid-19 complications in patients with pulmonary fibrosis[J].Sci Rep, 2021, 11(1): 14601
[85] 陈天赐, 李玲, 王小翠, 等.代谢组学在水产动物毒理学研究中的应用[J].饲料工业, 2021, 42(12):54
CHEN TC, LI L, WANG XC, et al. Application of metabonomics in toxicology of aquatic animals[J].Feed Ind Mag, 2021, 42(12):54
