[1] 韩红彬.疫苗预防流感流行的研究进展[J].药品评价,2018,15 (20):26
HAN HB. The Progress of vaccine against in uenza epidemic[J].Drug Eval,2018,15 (20):26
[2] SAITO S,AINAI A,SUZUKI T, et al. The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine[J].Vaccine,2016,34 (9):1201
[3] 黄星雨,袁佳敏,杨琼梁,等. 鼻用原位凝胶剂的研究进展[J].中国现代应用药学,2018,35 (3):448
HUANG XY,YUAN JM, YANG QL, et al. Research progress of nasal in-situ gel[J].Chin J Mod Appl Pharm,2018,35 (3):448
[4] KARIA N,CHANDAK R,RATHI A. Polymers in mucoadhesive drug delivery system: a brief note[J].Des Monomers Polym,2009,12 (6):483
[5] 程安媛. 新型胃粘附材料—白芨多糖的制备及膜粘附性体内外评价[D]. 重庆:重庆医科大学,2008
CHENG AY. A New Adhesive Material to Gastric Mucosa——Preparation of Bletilla Striata Polysaccharide and in Citro and in Vivo Evaluation of Its Mucosa Adhesion[D]. Chongqing:Chongqing Medical University,2008
[6] CALLENS C, CEULEMANS J, LUDWIG A, et al. Rheological study on mucoadhesivity of some nasal powder formulations[J].Eur J Pharm Biopharm,2003,55 (3):323
[7] LE RAY AM, IOOSS P, GOUYETTEE A, et al. Development of a "continuous-flow adhesion cell" for the assessment of hydrogel adhesion[J].Drug Dev Ind Pharm,1999,25 (8):897
[8] 李玉凤,邢绍荣,左宁,等. 探针法测定吲哚美辛凝胶剂粘附力的方法研究[J].药物分析杂志,2020,40 (5):948
LI YF, XING SR, ZUO N, et al. Study on the adhesion of indomethacin cataplasm by probe method[J].Chin J Pharm Anal,2020,40 (5):948
[9] MASIUK T, KADAKIA P, WANG Z. Development of a physiologically relevant dripping analytical method using simulated nasal mucus for nasal spray formulation analysis[J].J Pharm Anal, 2016, 6(5):283
[10] ZULKIFLI FH, SHAHITHA F, YUSUFF MM, et al. Cross-linking effect on electrospun hydroxyethyl cellulose/poly(vinyl alcohol) nanofibrous scaffolds[J].Proc Eng,2013,53 (53):689
[11] PANDEY J, SHANKAR R, KUMAR M, et al. Development of nasal mucoadhesive microspheres of granisetron: a potential drug[J].Drug Res,2020,70 (8):367
[12] 李晨曦. 用于鼻腔给药的载酮咯酸氨丁三醇温敏即型凝胶的制备与评价[D]. 黑龙江:黑龙江中医药大学,2014
LI CX. Prepration and Evaluation of Ketorolac Tromethamine-loaded in Situ Gel for Intranasal Administration[D]. Heilongjiang:Heilongjiang University of Chinese Medicine,2014
[13] 李馨儒,雷耀龙. 阿昔洛韦眼用pH敏感原位凝胶剂的制备和评价[J].中国新药杂志,2009,18 (24):2360
LI XR, LEI YL. Preparation and evaluation of ophthalmic pH sensitive in-situ gel of acyclovir[J].Chin J New Drugs,2009,18 (24):2360
[14] ANGADI SC, MANJESHWAR LS, AMINABHAVI TM. Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid[J].Int J Biol Macromol,2010,47 (2):171
[15] 任杰,姚萌奇,陶丽,等.P(VF-NIPAAm-AM)多重响应型复合水凝胶的制备及其性能研究[J].化学研究与应用,2016,28 (4):539
REN J, YAO MQ, TAO L, et al. Preparation and characterization of P(VF-NIPAAm-AM) multiresponsive composite hydrogel[J].Chem Res Appl,2016,28 (4):539
[16] 张罗,矫健,韩德民.药物对鼻腔黏液纤毛清除系统的影响[J].中华耳鼻咽喉头颈外科杂志,2013,48 (3):262
ZHANG L,JIAO J,HAN DM. Effect of drugs on nasal mucociliary clearance system[J].Chin J Otorhinolaryngol Head Neck Surg,2013,48 (3):262
[17] ILIUM L. Nasaldrug delivery:new developmentsand strategies[J].Drug Discov Today,2002,7 (23):1184
[18] SADHANA S. Spray dried nasal mucoadhesive microspheres of carbamazepine: preparation and in-vitro/ex-vivo evaluation[J].Res Pharm,2011,2 (1):21
[19] 石森林,李晓琦,施笑晖,等. 天麻素淀粉微球的制备及其鼻黏膜黏附性与体外释药特性考察[J].中草药,2016,47 (4):585
SHI SL,LI XQ,SHI XH, et al. mreparation of gastrodin starch microsphere and its nasal mucoadhesion and in vitro release characteristics[J].Chin Tradit Herb Drugs,2016,47 (4):585
[20] 于大海,叶齐政,杨芾藜,等. 图像灰度标准差对介质阻挡丝状放电分布均匀性的定量评价[J].中国电机工程学报,2013,33 (28):193
YU DH,YE QZ,YANG FL, et al. Evaluation of the distribution uniformity of filamentary dielectric barrier discharge by standard deviation of image gray levels[J].Proc CSEE,2013,33 (28):193
[21] 刘志伟. 哮喘气道黏液流变行为变化及其影响因素和临床意义的研究[D]. 常州:常州大学,2015
LIU ZW. Investigation of Airway Mucus Rheological Behaviors in Asthma and Their Determinants and Clinical Implications[D]. Changzhou: Changzhou Unibersity,2015
[22] 中华人民共和国药典2015年版.四部[S]. 2015:356
ChP 2015. Vol Ⅳ[S]. 2015:356
[23] 丁劲松,蒋学华. 胃肠道生物粘附制剂及其评价方法[J].中国药房,2002,13 (6):51
DING JS,JIANG XH. Gastrointestinal bioadhesive agents and their evaluation methods[J].China Pharm,2002,13 (6):51
[24] STIE MB, GÄTKE JR, WAN F. Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa[J].Carbohydr Polym,2020,242 (242):116428
[25] 张志荣,付劼,黄园,等. 卡泊姆与羟丙基甲基纤维素在体内外与大鼠胃肠粘膜粘附性的考察[J].药学学报,2001,36 (7):543
ZHANG ZR, FU J, HUANG Y, et al. Investigation of the bioadhesion of carbopol and hydroxyporpyl methelcellulose to rat gastriontesinal mucosa in vivo and in vitro[J].Acta Pharm Sin,2001,36 (7):543
[26] 丁劲松,蒋学华,程泽能. 萘哌地尔生物黏附性缓释胶囊处方及体外粘附力测定[J].中国医药工业杂志, 2003,34 (9):448
DING JS, JIANG XH, CHENG ZN. Formulation of naftopidil bioadhesive sustained release capsules and measurement of its bioadhesion in vitro[J].Chin J Pharm,2003,34 (9):448
[27] 王佳丽,罗明志,刘志伟,等. Fe2O3纳米颗粒对模拟哮喘气道黏液的流变学性能影响[J].生物医学工程学杂志,2017,34 (2):193
WANG JL, LUO ZM, LIU ZW, et al. Influence of Fe2O3 nanoparticles on the rheological properties of simulated asthma airway mucus[J].Biomed Eng,2017,34 (2):193
[28] CRASTER R V,MATAR O K. Surfactant transport on mucus films[J].J Fluid Mech,2000,425 (425):235
[29] 李锐,李多慧,全大萍,等. 新型温敏型肝素-泊洛沙姆水凝胶包载神经生长因子对糖尿病外周神经损伤修复的作用[J].中国药学杂志,2019,54 (12):992
LI R,LI DH,QUAN DP, et al. Novel thermosensitive heparin-poloxamer hydrogel bridge NGF to treat peripheral nerve injury in diabetics rats[J].Chin Pharm J,2019,54 (12):992
[30] 冯小聪,黄唯,周世卿,等. 鼻敏方通过NF-κB信号通路对肺脾气虚变应性鼻炎大鼠鼻黏膜水通道蛋白5的影响[J].中国实验方剂学杂志,2020,26 (8):81
FENG XC,HUANG W,ZHOU SQ, et al. Effect of bimin decoction on aquaporin 5 in nasal mucosa of allergic rhinitis rats with lung and spleen Qi deficiency syndrome Via NF-κB signaling pathway[J].Chin J Exp Tradit Med Form,2020,26 (8):81
[31] 陈奕霖,高强,呼吸道黏液纤毛清除系统建模研究[J].计算机仿真,2016,33 (6):386
CHEN YL,GAO Q. Study on modeling of airway mucociliary clearance system[J].Comput Integr Manuf,2016,33 (6):386
[32] 孙黎,范玉玲,乔喜芹. 体外粘附力测定方法的研究[J].黑龙江医药,2005,18 (6):434
SUN L,FAN YL,QIAO XQ. Study on the determination method of adhesion in vitro[J].Heilongjiang Med J,2005,18 (6):434