目的: 建立合成卡西酮类新精神活性物质4-F-3-Me-ɑ-PVP的检测鉴定方法。方法: 检材分别用GC-MS、UPLC-QTOF/MS)(溶剂为甲醇)及核磁共振波谱仪(溶剂为氘代甲醇)检测。结果: 检材经UPLC-QTOF MS实测的精确质量数[M+H]+为m/z 264.175 92,GC-MS检测得到的质谱主要特征离子分别为:m/z 126(基峰)、109、137,经GC-MS和UPLC-QTOF/MS数据分析,得到了匹配度很高的2种同分异构体物质4-F-3-Me-ɑ-PVP和3-F-4-Me-ɑ-PVP,经进一步用NMR对其测定并解析结构,确认了检材为新的合成卡西酮类新精神活性物质4-F-3-Me-ɑ-PVP。结论: 本研究建立的多技术联合方法能用于4-F-3-Me-ɑ-PVP的检测鉴定。该方法直观、明确、可靠、实用。
Objective: To establish a method for the detection and identification of a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP. Method: The samples were analyzed by GC-MS, UPLC-QTOF MS (solvent was methanol), and nuclear magnetic resonance spectrometry (solvent was deuterated methanol). Result: According to the UPLC-QTOF-MS data, the accurate protonated molecule [M+H]+ was m/z 264.175 92 (C16H23FNO+). The main characteristic ions by GC-MS were:m/z 126 (base peak), 109, 137. By the GC-MS and UPLC-QTOF MS data, the compounds could be one of two isomer substances 4-F-3-Me-ɑ-PVP and 3-F-4-Me-ɑ-PVP. After further structure analysis by NMR, the sample was confirmed as a new psychoactive substance of synthetic cathinone 4-F-3-Me-ɑ-PVP. Conclusion: The multi-technique combined method established in this study can be used for the detection and identification of 4-F-3-Me-ɑ-PVP. The method is intuitive, clear, reliable and practical.
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