综述专论

高光谱成像技术在医药领域中的应用进展研究*

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  • 1.长春中医药大学, 长春 130117;
    2.中国科学院长春光学精密机械与物理研究所, 长春 130033
第一作者 Tel: 15896962195; E-mail: 20203600013@stu.ccucm.edu.cn
**王恩鹏 Tel: (0431)86045256; E-mail: robbinwang@163.cm
谭鑫 Tel: 13756060524; E-mail: xintangrating@163.com

收稿日期: 2021-01-06

  网络出版日期: 2024-07-12

基金资助

*吉林省科技发展计划项目(20200404042YY, 20190201297JC, 20190304099YY); 国家重点研发计划项目(2019YFC1710704)

Research on application progress of hyperspectral imaging technology in medical field*

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  • 1. Changchun University of Chinese Medicine, Changchun 130117, China;
    2. Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China

Received date: 2021-01-06

  Online published: 2024-07-12

摘要

高光谱成像(hyperspectral image, HSI)技术是通过高光谱成像仪(高光谱相机)探测可见光光谱及不可见的近红外光谱(NIRS)范围内的波长, 接收每个像素含有的上百个不同波段的反射信息形成三维立体图像的1种新型检测技术。HSI技术可提供丰富的光谱信息和空间信息, 具有准确、实时、在线分析的优势, 近年来在医药领域得到了广泛应用, 未来在结合智能AI、5G、大数据区块链等先进的技术后将会发挥越来越重要的作用。本文就HSI技术在临床医学、中医学、基础医学、药学等医药领域的应用进行综述, 并对其未来在医药领域的发展前景进行展望。

本文引用格式

张慧娥, 叶萍, 李光, 杜连云, 张哲, 沈彦龙, 谭鑫, 王恩鹏 . 高光谱成像技术在医药领域中的应用进展研究*[J]. 药物分析杂志, 2021 , 41(8) : 1360 -1367 . DOI: 10.16155/j.0254-1793.2021.08.09

Abstract

Hyperspectral image (HSI) technology is a new detection technology that detects the wavelength in the range of visible light spectrum and invisible near-infrared spectrum (NIRS) by hyperspectral camera, and receives the reflection information of hundreds of different bands contained in each pixel to form a threedimensional image. HSI can provide rich spectral and spatial information, and has the advantages of accurate, real-time and in-situ. In recent years, HSI has been widely used in the field of medicine. In the future, HSI will play an increasingly important role after combining advanced technologies such as intelligent AI, 5 G and big data block-chain. This paper reviewed the application of HSI technology in clinical medicine, traditional Chinese medicine, pre-clinical medicine, pharmacy and other medical fields, and prospects its future development in the field of medicine.

参考文献

[1] CHIHARA H,OISHI N,ISHII A,et al.In vivo detection of atherosclerotic plaque using non-contact and label free near infrared hyperspectral imaging[J]. Atherosclerosis,2016,250(Complete): 106
[2] GUO R.The healing power of chinese herbs and medicinal recipes[J]. FACT,2009,60(1):94
[3] CHIN JA,WANG EC,KIBBE MR.Evaluation of hyperspectral technology for assessing the presence and severity of peripheral artery diseases[J]. Vasc Surg,2011,54(6):1679
[4] MILANIC M,PALUCHOWSKI LA,RANDEBERG LL.Hyperspectral imaging for detection of arthritis:feasibility and prospects[J]. Biomed Opt, 2015,20(9): 96011
[5] MARTIN R,THIES B.Hyperspectral hybrid method classification for detecting altered mucosa of the human larynx[J]. Int J Health Geogr,2012,11(21):1
[6] ZAKIAN C,PRETTY I,ELLWOOD R.Near-infared hyperspectral imaging of teeth for dental caries detection[J]. Biomed Opt,2009, 14(6) :064047
[7] YUDOVSKY D,NOUVONG A,SCHOMACKER K,et al.Assessing diabetic foot ulcer development risk with hyperspectral tissue oximetry[J]. Biomed Opt,2011,6(2):026009
[8] BEN AT,TONG Y,ACH T,et al.Spatial and spectral Characterization of human retinal pigment epithelium fluorophore families by ex vivo hyperspectral autofluorescence imaging[J]. Transl Vis Sci Technol,2016,5(3):5
[9] NOURI D,LUCAS Y,TREUILLET S.Hyperspectral interventional imaging for enhanced tissue visualization and discrimination combining band selection methods[J]. Int J Comput Assist Radiol Surg,2016,11(12):2185
[10] PARASCA SV,CALIN MA,MANEA D,et al.Hyperspectral index-based metric for burn depth assessment[J]. Biomed Opt Express, 2018,9(11):5778
[11] CHIN MS,BABCHENKO O,NOBEL L,et al.Hyperspectral imaging for burn depth assessment in an animal model[J]. Plast Reconstr Surg,2015,3(12):e591
[12] SALINAS JJ,SHAH M,ABDELBARY B,et al.Application of a novel method for assessing cumulative risk burden by county[J]. Int J Environ Res Public Health,2012,9(5):1820
[13] GEMMA P,NEIL L,CHRIS L,et al.Applying visible hyperspectral (chemical) imaging to estimate the age of bruises[J]. Med Sci Law,2007,47(3):225
[14] AKBARI H,KOSUGI Y,KOJIMA K,et al.Hyperspectral Image segmentation and its application in abdominal surgery[J]. Int JFunct Inf Pers Med,2009,2(2):201
[15] FABELO H,ORTEGA S,LAZCANO R,et al.An intraoperative visualization system using hyperspectral imaging to aid in brain tumor delineation[J]. Sensors(Basel),2018,18(2):430
[16] SIDDIQI M,LI H,FARUQUE F,et al.Use of hyperspectral imaging to distinguish normal,precancerous,and cancerous cells[J]. Cancer,2008,114(1) :13
[17] WANG C,ZHENG W,BU Y,et al.Multi-scale hyperspectral imaging of cervical neoplasia[J]. Arch Gynecol Obstet,2016,293(6) :1309
[18] NAGAOKA T,KIYOHARA Y,KOGA H,et al.Modification of a melanoma discrimination index derived from hyperspectral data: a clinical trial conducted in 2 centers between March 2011 and December 2013[J]. Skin Res Technol,2015,21(3):278
[19] ZHERDEVA LA,BRATCHENKO IA,MYAKININ OO,et al.In vivo hyperspectral imaging and differentiation of skin cancer[C]. //Optics in Health Care and Biomedical Options Ⅶ . International Society for Optics and Photonics,2016:100244G
[20] LU G,FEI B.Medical hyperspectral imaging:a review[J]. Biomed Opt ,2014,19(1):10901
[21] ENFIED KSS,MARTIN SD,MARSHALL EA,et al.Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence[J]. J Immunother,2019, 13(5):2248
[22] VASEFI F,KAMINSKA B,BRACKSTONE M,et al.Hyperspectral angular domain imaging for ex vivo breast tumor detection[C].// Imaging,Manipulation & Analysis of Biomolecules Cells & Tissues XI,SPIE,2013:85870S
[23] KIYOTOKI S,NISHIKAWA J,OKAMOTO J.Ewmethod for detection of gastric cancer by hyperspectral imaging:apilotstudy[J]. Biomed Opt,2013,18(2):026010
[24] VESELKOV KA,MIRNEZAMI R,STRITTMATTER N,et al.Chemo-informatic strategy for imaging mass spectrometry-based hyperspectral profiling of lipid signatures in colorectal cancer[J].Proc Natl Acad Sci USA,2014,111(3) :1216
[25] REGELING B,THIES B,GERSTNER AO,et al.Hyperspectral imaging using flexible endoscopy for laryngeal cancer detection[J]. Sensors,2016,16(8) :1288
[26] MCCORMACK DR,WALSH AJ,SIT W,et al.In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts[J]. Biomed Opt Express,2014,5(7) :2247
[27] SUCHER R,WAGNER T,SUCHER E,et al.Hyperspectral imaging (HSI) of human kidney allografts[J]. Ann Surg,2020,12(18):1
[28] NOURI D,LUCAS Y,TREUILLET S.Hyperspectral interventional imaging for enhanced tissue visualization and discrimination combining band selection methods[J]. Int J Comput Assist Radiol Surg,2016,11(12) :2185
[29] MORI M,CHIBA T,NAKAMIZO A,et al.Intraoperative visualization of cerebral oxygenation Rusing hyperspectral image data:a two-dimensional mapping method[J]. Int J Comput Assist adiol Surg,2014,9(6) :1059
[30] ZUZAK KJ,NAIK SC,ALEXANDRAKIS G,et al.Intraoperative bile duct visualization using near-infrared hyperspectral video imaging[J]. Am J Surg,2008,195(4) :491
[31] ZUZAK KJ,NAIK SC,ALEXANDRAKIS G,et al.Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery[J]. Anal Chem,2007,79(12) :4709
[32] SMITH RT,POST R,JOHRI A,et al.Simultaneous decomposition of multiple hyperspectral data sets:signal recovery of unknown fluorophores in the retinal pigment epithelium[J]. Biomed Opt Express,2014,5(12) :4171
[33] KASHANI AH,LOPEZ GR,SAATI S,et al.Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects:a study using hyperspectral computed tomographic imaging spectroscopy[J].Retina,2014,34(9) :1854
[34] CHIN JA,WANGE C,KIBBE MR.Evaluation of hyperspectral technology for assessing the presence and severity of peripheral artery disease[J].J Vasc Surg,2011,54(6) :1679
[35] MARTIN R,THIES B,GERSTNER AO.Hyperspectral hybrid method classification for detecting altered mucosa of the human larynx[J].Int J Health Geogr,2012,11(21) :1
[36] LEE JA,BIEl NM,KOZIKOWSKI RT,et al.In vivo spectral and fluorescence microscopy comparison of microvascular function after treatment with OXi4503,Sunitinib and their combination in Caki-2 tumors[J].Biomed Opt Express,2014,5(6) :1965
[37] WANG X,ZHANG B,YANG H,et al.Statistical analysis of tongue images for feature extraction and diagnostics[J] . IEEE Trans Image Process,2013,12(22):5336
[38] YAMAMOTO S,TSUMURE N,NAKAGUCHI T,et al.Regional imae analysis of the tongue color spectrum[J].Int J Comput Assist Radiol Surg,2011,6(1) :143
[39] JUNG CJ,KIM KH,JEON YJ,et al.Color Distribution Differences in the Tongue in Sleep Disorder[J]. Evid Based Complement Alternat Med,2014,6(3):328
[40] LI JX,WU HJ,LI G,et al.Application of hyperspectral imaging technique in objective diagnosis of TCM syndromes[J] . Spectrosc Spect Anal,2010,30(11) :3072
[41] ZHANG D,LI YL,WANG SY,et al.Imaging and spectral analysis of human face and hand by hyperspectral imaging technology[J]. Acta Laser Biol Sin,2014,23(4) :301
[42] MILANIC M,BJORGAN A,LARSSON M,et al.Detection of hypercholesterolemia using hyperspectral imaging of human skin[C] //. Clinical and Biomedical Spectroscopy and Imaging Ⅳ . SPIE,2015.
[43] ZHANG D,LI YL,WANG SY,et al.Apilot study oneffect so facupuncture and moxibustion by hyper- spectral imaging technique[J]. Evid Based Complement Alternat Med,2014,3(2):135212
[44] IM SB, LEE YH.Numerical analysis of the change in skin color due to ecchymosis and petechiae generated by cupping: a pilot study[J]. J Acupunct Meridian Stud,2014,7(6):306
[45] QING L, SHI Q.Pollution source identification of water body based on aqueous fingerprint-case study[J]. Guangpu,2016,36(8): 2590
[46] LI B,BEVERIDGE P,OHARE WT,et al.The application of visible wavelength reflectancehyperspectral imaging for the detection and identification of blood stains[J]. Sci Justice,2014,54(6):432
[47] EDELMA GJ,VAN LEEUWEN TG,AALDERS MC.Visualization of latent blood stains using visible reflectance hyperspectral imaging and chemometrics[J]. Forensic Sci,2015,60(S1) :S188
[48] CADD S,LI B,BEVERIDGE P,et al.The non-contact detection and identification of blood stained fingerprints using visible wavelength hyperspectral imaging:Part II effectiveness on a range of substrate[J]. Sci Justice ,2016,56(3):191
[49] PAYNE N,LANGLOIS C,LENNARD C, et al.Applying visible hyperspectral(chemical) imaging to estimate the age of bruises[J]. Med Sci Law,2007,47(3):225
[50] CROCE AC,FERRIGNO A,BOTTIROLI G, et al.Fluorescence excitation properties of bilirubin in solution and in serum[J]. J Photochem Photobiol B,2021,215:112121
[51] EDELMAN GJ,GASTON E,CULLEN PJ,et al.Hyperspectral imaging for non-contact analysis of forensic traces[J]. Forensic Sci Int,2012,223(1-3):28
[52] LI QX,YANG XG,ZHANG J.Study on microscope hyperspectral medical imaging method for biomedical quantitative analysis[J]. Sci Bull, 2008,6(53):1431
[53] TANKEU S,VERMAAK I,CHEN W,et al.Differentiation between two“fangji”herbal medicines,Stephania tetrandra and the nephrotoxic Aristolochia fangchi,using hyperspectral imaging[J]. Phytochemistry,2016,12(2):213
[54] VERMAAK I,VILJOEN A,LINDSROM SW.Hyperspectral imaging in the quality control of herbal medicines-the case of neurotoxic Japanese star anise[J]. Pharm Biomed,2013,5(75):207
[55] XIA Z,ZHANG C,WENG H,et al.Sensitive wavelengths selection in identification of Ophiopogon japonicus based on near-infrared hyperspectral imaging technology[J]. Int J Anal Chem,2017: 6018769
[56] KAJINO A,BAI W,YOSHIMURA N,et al.Identification of peach and apricot kernels for traditional Chinese medicines using near-infrared spectroscopy[J]. Vibrat Spectrosc,2021,3(113): 103202
[57] FENG J,LIU Y,SHI X,et al.Potential of hyperspectral imaging for rapid identification of true and false honeysuckle tea leaves[J]. Food Meas Charact,2018,12(251):2184
[58] SANDASI M,CHEN W,VERMAAK I,et al.Application of vibrational spectroscopy techniques in the qualitative assessment of material traded as ginseng[J]. Molecules,2016,21(4):472
[59] SHEN T, YU H, WANG YZ.Assessing geographical origin of gentiana rigescens using untargeted chromatographic fingerprint, data fusion and chemometrics[J]. Molecules,2019,24(14):2562
[60] HE J,HE Y,ZHANG AC .Determination and visualization of peimine and peiminine content in Fritillaria thunbhuergii Bulbi treated by sulfur fumigation using hyperspectral imaging with chemometrics[J]. Molecules,2017,22(9):1402
[61] YANG B, XIE Y,GUO M, et al.Nephrotoxicity and Chinese herbal medicine[J]. Clin J Am Soc Nephrol,2018,13(10):1605
[62] HAMILTON SJ,HAMILTON AE,LOWELL RA.Hyperspectral techniques in analysis of oral dosage forms[J]. Biomed Opt,2002, 7(4):561
[63] DJOKAM M,SANDASI M,CHEN WY,et al.Hyperspectral imaging as a rapid quality control method for herbal teablends[J] .Appl Sci,2017,7(3) :268
[64] 石吉勇, 邹小波,张德涛,等. 不同颜色银杏叶总黄酮含量分布高光谱图像检测[J]. 农业机械学报, 2014,45(11):242
SHI JY,ZOU XB,ZHANG DT, et al.Hyperspectral image detection of total flavonoids content in Goba biloba leaves of different colors[J]. Trans Chin Soc Agric Mach,2014,45(11):242
[65] ZOU X,SHI J, CHEN W, et al.Detection of triterpene acids distribution in loquat(Eriobotrya japonica) leaf using hyperspectral imaging[J]. Spectrochim Acta A Mol Biomol Spectrosc,2018, 188:436
[66] HUANG L,ZHOU Y,MENG L,et al.Comparison of different CCD detectors and chemometrics for predicting total anthocyanin content and antioxidant activity of mulberry fruit using visible and near infrared hyperspectral imaging technique[J]. Food Chem,2017,1(224):1
[67] ZHANG C,WU W,ZHOU L,et al.Developing deep learning based regression approaches for determination of chemical compositions in dry black goji berries(Lycium ruthenicum Murr.) using near-infrared hyperspectral imaging[J]. Food Chem,2020,30(319): 126536
[68] FABELO H,ORTEGA S,RAVI D,et al.Spatio-spectral classification of hyperspectral images for brain cancer detection during surgical operations[J]. PLoS One,2018,13(3):e0193721
[69] MARTINEZ B,LEON R,FABELO H,et al.Most relevant spectral bands identification for brain cancer detection using hyperspectral imaging[J]. Sensors(Basel),2019,19(24):5481
[70] CHU B,YU K,ZHAO Y,et al.Development of noninvasive classification methods for different roasting degrees of Coffee Beans using hyperspectral imaging[J]. Sensors(Basel),2018 ,18(4): 1259
[71] OLIVEIRA AL.Biotechnology,big data and artificial intelligence[J]. Biotechnol J,2019 ,14(8):e1800613
[72] HUANG S,YANG J,FONG S,et al.Mining prognosis index of brain metastases using artificial intelligence[J]. Cancers(Basel),2019 , 11(8):1140
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