综述专论

款冬花中吡咯里西啶生物碱类成分质量控制研究进展*

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  • 1.中国食品药品检定研究院,北京 102629;
    2.首都医科大学中医药学院,北京 100069
第一作者 昝珂Tel:(010)67095424; E-mail: 6206310@qq.com; 张睿Tel:(010)67095424; E-mail: 1467648687@qq.com
**马双成 Tel:(010)53852072; E-mail: masc@nifdc.org.cn; 金红宇Tel:(010)53851314; E-mail: jnhy @nifdc.org.cn

收稿日期: 2020-02-01

  网络出版日期: 2024-07-12

基金资助

*科技部国家科技重大专项(民口)课题重大新药创制“中药组分资源库及产业公共技术服务平台建设”(2018ZX09735-006)

Research progress of quality control of pyrrolizidine alkaloids in Farfarae Flos

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  • 1. National Institutes for Food and Drug Control, Bejjing 102629, China;
    2. China School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China

Received date: 2020-02-01

  Online published: 2024-07-12

摘要

款冬花是常用中药材之一,除有效成分外,还含有多种吡咯里西啶生物碱类成分,该类成分具有较强的肝毒性,但现行的质量标准中均没有对该类成分的限量控制和风险提示,长期服用该药材,存在较大的用药安全风险。本文对近年来款冬花中吡咯里西啶生物碱的化学成分、毒性研究和质量控制进行综述,以期为该药材的质量评价和用药安全提供参考。

本文引用格式

昝珂, 张睿, 李耀磊, 王莹, 刘丽娜, 王丹丹, 马双成, 金红宇 . 款冬花中吡咯里西啶生物碱类成分质量控制研究进展*[J]. 药物分析杂志, 2021 , 41(5) : 753 -759 . DOI: 10.16155/j.0254-1793.2021.05.02

Abstract

Farfarae Flos is one of the commonly used Chinese medicinal materials. Besides the active ingredients, various pyrrolizidine alkaloids were detected in this medicinal material,which have strong hepatotoxicity. However, the current quality standards do not have the limitation and risk reminder of these ingredients. If the herb is used for a long time,there is a greater risk of drug safety. In this paper,the chemical constituents, toxicity studies and quality control of pyrrolizidine alkaloids in Farfarae Flos in recent years were reviewed in order to provide reference for the quality evaluation and safety use of the drug.

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