综述专论

样品衍生化技术在中药分析中的应用现状

  • 张欣悦 ,
  • 陶冶 ,
  • 徐新房 ,
  • 李千 ,
  • 张海霞 ,
  • 姜水蓝 ,
  • 刘艺淇 ,
  • 杨超 ,
  • 程显隆 ,
  • 李向日 ,
  • 魏锋
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  • 1.北京中医药大学中药学院,北京 102488;
    2.中国食品药品检定研究院,北京 102629;
    3.安徽省食品药品检验研究院 国家药品监督管理局中药质量研究与评价重点实验室,合肥 230051
第一作者 张欣悦 Tel:(010)84738616;E-mail:zxinyue0416@163.com
陶冶 Tel:(0551)63358053;E-mail:13856080281@163.com
* 李向日 Tel:(010)84738616;E-mail:lixiangri@sina.com
魏锋 Tel:(010)53852020;E-mail:weifeng@nifdc.org.cn

网络出版日期: 2025-10-13

Application of sample derivatization techniques in the analysis of traditional Chinese medicine

  • ZHANG Xin-yue ,
  • TAO Ye ,
  • XU Xin-fang ,
  • LI Qian ,
  • ZHANG Hai-xia ,
  • JIANG Shui-lan ,
  • LIU Yi-qi ,
  • YANG Chao ,
  • CHENG Xian-long ,
  • LI Xiang-ri ,
  • WEI Feng
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  • 1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
    2. National Institutes for Food and Drug Control, Beijing 102629, China;
    3. Anhui Institutes for Food and Drug Control,NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Hefei 230051, China

Online published: 2025-10-13

摘要

中药分析涉及中药质量控制、中药物质基础研究等多个领域,是中药现代化研究的基础。近年来,衍生化技术作为样品前处理中的重要方法之一,已广泛应用于中药分析中,旨在改善待测组分稳定性、灵敏度、选择性和分离度等问题。本文概述了样品衍生化技术的相关知识,介绍其在气相色谱和高相液相色谱中的应用情况,并结合中药分析实例,阐述其在不同中药化学成分研究中的应用,为中药分析前处理过程中样品衍生化技术提供参考。

本文引用格式

张欣悦 , 陶冶 , 徐新房 , 李千 , 张海霞 , 姜水蓝 , 刘艺淇 , 杨超 , 程显隆 , 李向日 , 魏锋 . 样品衍生化技术在中药分析中的应用现状[J]. 药物分析杂志, 2025 , 45(4) : 554 -563 . DOI: 10.16155/j.0254-1793.2024-0442

Abstract

The analysis of traditional Chinese medicine involves many fields, such as quality control of traditional Chinese medicine and basic research of traditional Chinese medicine substances, and is the basis of modernization research of traditional Chinese medicine. In recent years, derivatization technique, as one of the important methods in sample pretreatment, has been widely used in the analysis of traditional Chinese medicine, aiming to improve the stability, sensitivity, selectivity and separation of the components to be measured. This paper outlines the knowledge of sample derivatization technique, introduces its application in gas chromatography and high-phase liquid chromatography, and describes its application in different chemical compositions of traditional Chinese medicine with examples of traditional Chinese medicine analysis, so as to provide a reference for sample derivatization technique in the pre-treatment process of traditional Chinese medicine analysis.

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